As a follow-up to my previous post: The highly engineered transition to vertebrates: an example of functional information analysis I am presenting here some results obtained by a general application, expanded to the whole human proteome, of the procedure already introduced in that post. Main assumptions. The aim of the procedure is to measure a well defined equivalent of functional information in proteins: the information that is conserved throughout long evolutionary times, in a well specified evolutionary line. The simple assumption is that  such information, which is not modified by neutral variation in a time span of hundreds of million years, is certainly highly functionally constrained, and is therefore a very good empirical approximation of the value of functional information in a protein. … Continue reading The amazing level of engineering in the transition to the vertebrate proteome: a global analysis