BREAKING: President Trump, Mrs Trump & Ms Hicks are Positive for CV-19

_{kairosfocus
October 2, 2020

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Tweets:

Tonight, @ FLOTUS and I tested positive for COVID-19. We will begin our quarantine and recovery process immediately. We will get through this TOGETHER!
— Donald J. Trump (@ realDonaldTrump) October 2, 2020

Hope Hicks, who has been working so hard without even taking a small break, has just tested positive for Covid 19. Terrible! The First Lady and I are waiting for our test results. In the meantime, we will begin our quarantine process!
— Donald J. Trump (@ realDonaldTrump) October 2, 2020

When you thought an extraordinarily chaotic year could not pull out another twist. Well, here it is. END

PS: As broad context

PPS: For reference on HCQ

Also:

PPPS: A sampler from a former CEO, Twitter (cf discussion at Forbes [also here]) commented on by Michelle Malkin, a few days ago:

See, now, that this is NOT a normal silly season cycle?

PPPPS: A summary on the U/L trajectory of CV19:

Comments

Again, from the paper I provided to support my claim:
Recent Findings Out of these drugs, chloroquine (CQ) and hydroxychloroquine (HCQ) have demonstrated positive results indicating a potential antiviral role against SARS-CoV-2. Its mechanism of action (MOA) includes the interference in the endocytic pathway, blockade of sialic acid receptors, restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site and prevention of cytokine storm.
It is a RECENT FINDING that restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site. As I said, obviously RHolt and mac and cheese cannot read for comprehension. Heck RHolt came here slamming the the concept HCQ can change then pH levels. After being corrected on that RHolt started running around with the goalpost and ignored everything that refuted his ignorance.ET_{October 8, 2020
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Mac and cheese is clearly just an insipid troll. I have defended my claims. Your willful ignorance isn't my problem. RHolt's inability to read for comprehension isn't my problem. But it is hilarious that all you are is a misguided cheerleader and a pathological liarET_{October 8, 2020
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No daves. I won't get it unless it is mandatedET_{October 8, 2020
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RHolt, a tip of my hat to you. You have far more patience and tolerance than I have. ET has a long and storied history of resorting to name-calling when he can't defend his claims. Whenever he starts using terms like "insipid troll", "liar", "quote mining", "willfully ignorant", and "cannot read for comprehension", you know that he is just blowing hot air and has no support for his claims. I can't imaging that there are many sites where he is allowed to comment.Mac McTavish_{October 8, 2020
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ET, Assuming a vaccine comes out in a few months, will you get it?daveS_{October 8, 2020
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And it is nice to see that Mac and cheese has been relegated to being a misguided cheerleader. :razz:ET_{October 8, 2020
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Why require a vaccine when OTC supplements can do the job?ET_{October 8, 2020
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Do these people need a vaccine? According to the CDC’s data, the survival rate for C19 is as follows:
0-19: 99.997% 20-49: 99.98% 50-69: 99.5%
Especially when there are effective treatments for those who get the virus.jerry_{October 8, 2020
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It is very telling that RHolt refuses to go to the source of the data.ET_{October 8, 2020
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RHolt- I have presented my references. You choked on them. And showing there isn't any conformational change isn't proving a negative. It is showing the positive results of the ACE2 receptors staying the same in the presence of HCQ. And that $200,000 challenge still stands. Can hardly wait for more of your lies about thatET_{October 8, 2020
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Jerry: For example, they have found a large percentage of US blood donations from a few years ago had T cells against the virus. Yes, I heard about that result as well. What did your source hypothesise was the cause of that?JVL_{October 8, 2020
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That seems to be your stock reply when you cannot refute what has been stated.
You did not state anything except a denial. So yes, your reply was nonsense. I have been reading discussions for weeks on immunity and have read the CDC document on vaccines. Nothing what I asked or suggested contradicts what is known. For example, they have found a large percentage of US blood donations from a few years ago had T cells against the virus. I participate in these blog discussions to learn what is known. No one here has provided anything against what I suggested. I find that interesting. RHampton is the best advocate I know for HCQ since in almost 500 posts over 6 months he has provided nothing against HCQ except for fake news and quotes from medical bureaucrats.jerry_{October 8, 2020
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ET @ 291 'Contact the authors of the paper. Contact the French an Chinese research teams. Contact the author of the article from Watts Up. Or live in your willfully ignorant world.' The last gasp of the failure to support your claim with a single reference documenting conformational changes in the ACE2 receptor as a result of HCQ treatment. I think the readers will, at this point in time, consider the 'willfully ignorant world' comment of yours to be projection on your part.RHolt_{October 8, 2020
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ET @ 286 'Do your research and demonstrate there isn’t any conformational change in the ACE2 receptors in the presence of HCQ. or shut up. ' You want me to prove a negative rather than you bearing the burden of supporting your claim with confirming data? Science doesn't work that way, ET. You claim the knowledge that HCQ causes conformational changes in the ACE2 receptor yet you can't provide any references with data supporting this notion. You can't tell me what, exactly, constitutes these changes. Telling, very telling, ET.RHolt_{October 8, 2020
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RHolt:
If it is widely known where are e references that demonstrate, and document these changes?
Contact the authors of the paper. Contact the French an Chinese research teams. Contact the author of the article from Watts Up. Or live in your willfully ignorant world.ET_{October 8, 2020
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And stop quote-mining my comments. It proves that you are a desperate and insipid troll.ET_{October 8, 2020
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ET @ 285 'The mechanism that makes it change shape is widely known- this restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site is a given.' If it is widely known where are e references that demonstrate, and document these changes? We know that TMPRSS2 is unaffected by pH changes (in the order of physiologically feasable pH values....I'm sure a pH of 2 would denature the enzyme) so what enzyme are you talking about that interacts with sars-cov-2 spike protein if it isn't TMPRSS2 that cleaves the S protein into its subunits in human lung and airway cells?RHolt_{October 8, 2020
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The paper says the change happens-> restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site . The challenge was to see if said change also provided an advantage against the virusET_{October 8, 2020
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ET @ 283 'You denied the reference I posted' More bluffing. I pointed out that the reference you provided has no data to document the claim being made. Nor, as I pointed out, do the references cited in that article contain any such information. If you think the article has data documenting the conformational change(s) of the ACE2 receptor ten tell me how this was determined. What research methodology was used; x-ray crystallography or something else?RHolt_{October 8, 2020
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RHolt- you are just an insipid troll who cannot read for comprehension. Now you are just a liar spewing its desperate lies. Prove its a sham monetary challenge or shut up. Do your research and demonstrate there isn't any conformational change in the ACE2 receptors in the presence of HCQ. or shut up.ET_{October 8, 2020
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The mechanism that makes it change shape is widely known- this restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site is a given.ET_{October 8, 2020
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ET @ 280 'And RHolt- until you collect that $200,000 from Dr. Zelenko, you really don’t have anything to say about HCQ’s effectiveness for fighting covid-19.' I think this is one of your funniest of gambits. Funny because you think science moves forward based on sham monetary challenges. Funnier because you always bring it up when you hit a brick wall trying to find some data to support your claims. Something you claim has been known for years yet no references to document this knowledge appears to exist. That is curious, isn't it, ET?RHolt_{October 8, 2020
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RHolt- Your ignorance does not equate to my bluffing. What is wrong with you? You denied the reference I posted. You have proven to be unable to read for comprehension. You are nothing but an insipid trollET_{October 8, 2020
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RH&:
2 Covid-19 is more fatal than flu
Not true for kids. More kids, ages 0-18 died from the flu than died from covid-19, ages 0-24.ET_{October 8, 2020
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ET @ 278 'The research that went into HCQ for rheumatoid arthritis' What research into RA included/documented ACE@ receptor conformational change? You have now regressed to bluffing and trying to bullying your way out of admitting that you cannot find a single source of data that support your claim. As I stated several times now, there might be a reason for that, ET.RHolt_{October 8, 2020
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And RHolt- until you collect that $200,000 from Dr. Zelenko, you really don't have anything to say about HCQ's effectiveness for fighting covid-19.ET_{October 8, 2020
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Jerry @ 273 'RHolt. All nonsense!!!' That seems to be your stock reply when you cannot refute what has been stated. Reminds me of the comments I made on your boulware reference critique. in that critique you include numbers and conclusions that are not even found in the publication. when faced with the facts, substantiated with quotes from the article, you claim 'nonsense' and flee the scene. A very apparent and telling pattern of interaction.RHolt_{October 8, 2020
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RHolt:
What research shows there was a change?
The research that went into HCQ for rheumatoid arthritis. YOU can actually look it up. Or remain willfully ignorant. I don't care. YOU have provided nothing but your denial and inability to read for comprehensionET_{October 8, 2020
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ET @ 275 'It clearly says that the research showed there was a change and that the change may prevent infection.' What research shows there was a change? Seems I've asked this question before and if, as you state, this is a given and known for years (decades) there should be oodles of references documenting this. You can't even come up with one. Might be a reason for that, ET.RHolt_{October 8, 2020
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Jerry @ 270 'If there is an effective treatment that does not depend on the variant of the virus, would a vaccine be necessary' Yes, a vaccine would be necessary for any of a number of common sense medically-based reasons. Your conspiracy theories on HCQ and its suppression is only slightly humorous up and until the point when you recognize that the indulgence in such folly put peoples lives in danger and result in the loss of life. Jerry @ 265 'On the other side there are many large studies showing effectiveness.' I believe the large studies you are referring too are similar, if not exactly, those put out by Raoult. In these studies 95% of the patients had NEWS scores of 2. By this point in time everyone following this disease and treatment development knows that patients with NEWS scores of 2 are likely to have no serious adverse events. You could give these patients chocolate milkshakes and they would have the same percentages of success as these poorly conducted HCQ studies generated. Which is why Raoult has been excoriated by his peers for his shoddy work and study presentation. Another point is Trump clams to have designed his own treatment regime. Obviously missing from the HCQ promoters-in-chief's regime is HCQ. One doesn't need to wonder why it wasn't included. The reason is all too obvious. He reached the same conclusion as the majority of the practicing medical treatment and research community.....HCQ doesn't work. We see this confirmation in human lung and airway cell culture results where HCQ fails to inhibit viral replication and infection.RHolt_{October 8, 2020
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