It’s an impossible exercise if you leave out design: The same shortcomings and omissions that plague current OOL research can also be found in the paper under review. Indeed, these issues are so routinely ignored by researchers that the field appears to have become numbed to their absence from the literature. OOL researchers are prepared to assume that an ever-increasing list of obstacles were overcome on the prebiotic earth, but do not consider these hurdles as problems to be solved in their own work. The following five shortcomings in the research presented by Krishnamurthy et al., are emblematic of broader issues that need to be addressed. James Tour, “Much Ado About Nothing” at Inference Review (January 2022)