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Body plan organizer “much more ancient than previously thought”


600 mya. From ScienceDaily:

Cells need to ‘know’ where they are in relation to all other cells in order to give rise into the correct cell types and tissues. The so-called ‘organizer’ is responsible for the formation of these body axes. Developmental biologists have shown that the molecular principles of the organizer are much more ancient than previously thought. The same signals were used already in the common ancestor of sea anemones and vertebrates 600 million years ago.

In vertebrate early development, an “organizer” forms in the region of the primitive mouth (the blastopore) of the embryo. This organizer is responsible for guiding axis formation of the organism. Its discovery won Hans Spemann a Nobel Prize in 1935. The organizer tissue instructs the surrounding cells to take part in body axes development, enforcing a certain developmental fate on them. Without an organizer, the embryo would not know where the head, the tail, the back and the belly should be. Mistakes in the regulation of body axes can lead to severe developmental defects, for example to the formation of Siamese twins.

In the last 25 years, the researchers largely elucidated the genetic underpinnings of this very particular part of the vertebrate embryo. The widespread assumption was that the organizer was a specific vertebrate feature, since it was not readily observable in insect or worm embryos. Paper. (public access) – Yulia Kraus, Andy Aman, Ulrich Technau, Grigory Genikhovich. Pre-bilaterian origin of the blastoporal axial organizer. Nature Communications, 2016; 7: 11694 DOI: 10.1038/ncomms11694 More.

But it turns out the molecular underpinnings from 600 mya were in them too. It looks far more like a pattern than like random evolution. Michael Denton is right.

See also: Michael Denton on the discontinuity of nature


Stasis: Life goes on but evolution does not happen

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Contrary to the authors's materialistic premises, body plans are not nearly as reducible to a materialistic basis as they falsely presuppose.
Intelligent Design Might Be Wrong, But Not the Way You Think by Stephen H. Webb - February 2014 Excerpt: Darwin, like all moderns, believed that matter was something particular, that matter is composed of small bits of stuff called atoms, and thus it can be pushed from behind, as it were, without being pulled from beyond, by form. http://www.firstthings.com/web-exclusives/2014/02/occasionalism-intelligent-design-and-the-myth-of-secondary-causation The Insurmountable Problem of “Form/Shape” for Darwinian Explanations – video (2016) https://www.facebook.com/philip.cunningham.73/videos/vb.100000088262100/1138468566166075/?type=2&theater Scientific evidence that we do indeed have an eternal soul (Elaboration on Talbott's question “What power holds off that moment — precisely for a lifetime, and not a moment longer?”)– video 2016 https://www.facebook.com/philip.cunningham.73/videos/vb.100000088262100/1116313858381546/?type=2&theater Molecular Biology - 19th Century Materialism meets 21st Century Quantum Mechanics - video https://www.facebook.com/philip.cunningham.73/videos/vb.100000088262100/1141908409155424/?type=2&theater Jim Al-Khalili, at the 2:30 minute mark of the following video states, ",,and Physicists and Chemists have had a long time to try and get use to it (Quantum Mechanics). Biologists, on the other hand have got off lightly in my view. They are very happy with their balls and sticks models of molecules. The balls are the atoms. The sticks are the bonds between the atoms. And when they can't build them physically in the lab nowadays they have very powerful computers that will simulate a huge molecule.,, It doesn't really require much in the way of quantum mechanics in the way to explain it." At the 6:52 minute mark of the video, Jim Al-Khalili goes on to state: “To paraphrase, (Erwin Schrödinger in his book “What Is Life”), he says at the molecular level living organisms have a certain order. A structure to them that’s very different from the random thermodynamic jostling of atoms and molecules in inanimate matter of the same complexity. In fact, living matter seems to behave in its order and its structure just like inanimate cooled down to near absolute zero. Where quantum effects play a very important role. There is something special about the structure, about the order, inside a living cell. So Schrodinger speculated that maybe quantum mechanics plays a role in life”. Jim Al-Khalili – Quantum biology – video https://www.youtube.com/watch?v=zOzCkeTPR3Q
Verse, Music and video:
Jeremiah 1:5 "Before I formed you in the womb I knew you, before you were born I set you apart; I appointed you as a prophet to the nations." Hillsong UNITED - Touch The Sky Feat. Taya Smith (Live From Passion 2016) https://www.youtube.com/watch?v=Yzssegj5-ks Special Relativity and General Relativity compared to Heavenly and Hellish Near Death Experiences - video https://www.facebook.com/philip.cunningham.73/videos/vb.100000088262100/1113745045305094/?type=2&theater
semi related:
Dan S. Tawfik Group - The New View of Proteins - Tyler Hampton - 2016 Excerpt: one of the most favorable and liberal estimates is by Jack Szostak: 1 in 10^11. 42 He ascertained this figure by looking to see how random sequences—about eighty amino acids in length, long enough to fold—could cling to the biologically crucial molecule adenosine triphosphate, or ATP. At first glance, this is an improvement over Salisbury’s calculations by 489 powers of ten. But while an issue has been addressed, the problem has only been deferred. ,,, ,,, nucleotide synthesis, requires several steps. If five enzyme functions were needed (ten are needed in modern adenine synthesis), 43 then the probability would be 1 in (10^11)5, or 1 in 10^55. If all the operations needed for a small autonomous biology were ten functions—this is before evolution can even start to help—the probability is 1 in (10^11)10, or 1 in 10^110. This is more than the number of seconds since the Big Bang, more protons than there are in the universe. In considering a similar figure derived in a different context, Tawfik concedes that if true, this would make “the emergence of sequences with function a highly improbable event, despite considerable redundancy (many sequences giving the same structure and function).”44 In other words, these odds are impossible.,,, Tawfik soberly recognizes the problem. The appearance of early protein families, he has remarked, is “something like close to a miracle.”45,,, “In fact, to our knowledge,” Tawfik and Tóth-Petróczy write, “no macromutations ... that gave birth to novel proteins have yet been identified.”69 The emerging picture, once luminous, has settled to gray. It is not clear how natural selection can operate in the origin of folds or active site architecture (of proteins). It is equally unclear how either micromutations or macromutations could repeatedly and reliably lead to large evolutionary transitions. What remains is a deep, tantalizing, perhaps immovable mystery. http://inference-review.com/article/the-new-view-of-proteins
Some questions: What organizes the organizer? What was first the organizer or the body plan? How about those endogenous electric fields in the membrane? The organizer not only has the information for the adult organism's body plan, but also has the information wrt the building process. That is a lot of information. Where is this information stored? In Junk-DNA? Origenes

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