Intelligent Design Proteome

The remarkable expansion of the proteome across the history of life

A friend writes to draw our attention to this sentence: “Life met this challenge by evolving molecular chaperones that can minimize protein misfolding and aggregation, even under stressful out-of-equilibrium conditions favoring aggregation.” “Life” is a busy little bee, no? If this were not evolutionary biology, we would talk in terms of purpose and design. Oh but, whoops, they do talk in terms of purpose and design. But none dare call it that.

Intelligent Design Irreducible Complexity Proteome

Film clip on the probability of a protein forming by chance passes 500k views

xcerpt: Putting the probabilities together means adding the exponents. The probability of getting a properly folded chain of one-handed amino acids, joined by peptide bonds, is one chance in 10^74+45+45, or one in 10^164 (Meyer, p. 212). This means that, on average, you would need to construct 10^164 chains of amino acids 150 units long to expect to find one that is useful.

Culture Evolution Intelligent Design Proteome

Paleoproteomics: Ancient proteins shed more light on the past

From Catherine Offord at the at The Scientist: In one recent project, for example, Schroeter and her advisor Mary Schweitzer extracted and analyzed collagen peptides from just 200 mg of an 80-million-year-old fossil of a Cretaceous-era herbivore, Brachylophosaurus canadensis, excavated in Montana. The amino acid sequences of those peptides, published last year, placed the dinosaur on Read More…

Biophysics Cell biology Design inference Informatics Intelligent Design Proteome

Discovery of 7 times higher complexity of protein folding!

Can protein folding complexity be formed by stochastic processes? With 14 intermediate steps? JILA Team Discovers Many New Twists in Protein Folding Biophysicists at JILA have measured protein folding in more detail than ever before, revealing behavior that is surprisingly more complex than previously known. . . . They fold into three-dimensional shapes that determine Read More…