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Evolutionary biologist sees mutation driving evolution and thinks natural selection is of secondary importance

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The author is Matastoshi Nei, Evan Pugh Professor of Biology and Director of the Institute of Molecular Evolutionary Genetics, who seems well-connected in the science world :

The purpose of this book is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with natural selection being of only secondary importance. The word ‘mutation’ is used to describe any kind of change in DNA such as nucleotide substitution, gene duplication/deletion, chromosomal change, and genome duplication. A brief history of the principal evolutionary theories (Darwinism, mutationism, neo-Darwinism, and neo-mutationism) that preceded the theory of mutation-driven evolution is also presented in the context of the last 150 years of research. However, the core of the book is concerned with recent studies of genomics and the molecular basis of phenotypic evolution, and their relevance to mutation-driven evolution. In contrast to neo-Darwinism, mutation-driven evolution is capable of explaining real examples of evolution such as the evolution of olfactory receptors, sex-determination in animals, and the general scheme of hybrid sterility. In this sense the theory proposed is more realistic than its predecessors, and gives a more logical explanation of various evolutionary events.

Nicolas Galtier, introducing the book at Systematic Biology, offers a psychological explanation for the current obsession with Darwin’s natural selection:

There must be reasons for this, of which one is perhaps historical. To convince people that biological entities were not god-made creatures, Darwin and its followers had to simultaneously argue 1) that living forms change in time and 2) that their adaptations are sufficiently well explained by the process of natural selection. So, the two concepts have been and still are tightly associated in the context of anticreationist arguments. There might also be psychological reasons. Natural selection, unlike divine creation, is not an intuitive idea. Those who adopt it typically like it very much, and can hardly resist coming back to it again and again, finding the living world even more marvelous knowing that it was not generated by a creator. In a way, natural selection has somewhat replaced divine creation in many people’s minds as the process responsible for the beauty of nature.

The new book Mutation-Driven Evolution firmly opposes this view of natural selection as the unique biological creative force. …

You’d have to pay or sign in to read more. Even the review at Trends in Ecology & Evolution is paywalled.

Comments
wd400 wrote:
You and I both have about 60 new mutations. If mutations are nearly universally bad, why are we alive?
I replied:
Look man, don’t insult my intelligence, alright. You’re only counting the harmless mutations that the system allows by design. You are not counting the countless mutations that the system repairs automatically. We would all be dead without the gene repair mechanisms.
wd400 countered:
Ah, the unsinkable rubber ducky. Those mutations that make it into each generation do so via devine provenance? Even if that was the case, the point remains. If most realised mutations are bad news why are you and I alive? Non-realised mutations don’t matter for evolution, surely?
I was correct. Darwinian evolution is for morons and liars with an ideological and political ax to grind.Mapou
January 9, 2014
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Natural selection is a requirement for stasis. Natural selection is a requirement for change. If the same explanation fits two opposite examples it's not a very useful scientific explanation! Even with conservative estimates on percentage of deleterious mutations 10-20% it's still bad for evolution. That calculates to 6-20 deleterious mutations per generation as there are about 60-100 mutations per gen. That's enough to make a descendant less fit than the parent but the mutations are not so deleterious that they will wipe the organism. There are plenty of genes in humans that this build up hasn't seemed to be wiping us out yet. Furthermore, with genetic redundancy and such it seems like organisms were "predesigned" to account for this.sixthbook
January 9, 2014
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wd400:
Natural selection is a requirement for stasis. THanks to mutation and finite population sizes, change is the gound state for any evolutionary process. To prevent change form happening you need some non-random force, and that force is “balancing selection” keeping creatures similar and well-adapted to their niche.
You sound like a baraminologist.Joe
January 9, 2014
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Actually, Mahuna, Can you share your reference for the idea modern horses are identical to ancient North American ones? I don't think that's right (Or, at least, we should expect them to be identical at many genetic loci since the 12 000 years since Nth American extinction is very recent, and few genes would be subject to selectoin in the breeding of european horses. But they won't be identical at all loci, and indeed different breeds of modern horses are not.)wd400
January 9, 2014
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News, Yes. That's precisely the point. Almost as if darwinian mechanisms for just one part of evolutionary biology, a field that contains many different schools. "Darwinism" might be a useful term to apply to those topics that related directly to natural selection, but is hardly appropriate for, say, discussions of junk DNA where the mechanims at play a non-Darwinian. I was hoping this might be the moment someone here gets that. Mapou, Ah, the unsinkable rubber ducky. Those mutations that make it into each generation do so via devine provenance? Even if that was the case, the point remains. If most realised mutations are bad news why are you and I alive? Non-realised mutations don't matter for evolution, surely? Mahuna, Natural selection is a requirement for stasis. THanks to mutation and finite population sizes, change is the gound state for any evolutionary process. To prevent change form happening you need some non-random force, and that force is "balancing selection" keeping creatures similar and well-adapted to their niche.wd400
January 9, 2014
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Brookfield's review of Nei's bookIan Thompson
January 9, 2014
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Mutations do provide information but it is natural selection that makes this specific to the niche that the organism resides.
Evidence please.Joe
January 9, 2014
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The problem with pushing natural selection as a mechanism is that the odds are quite good that what is advantageous in one generation is a disadvantage in the next. The finch beaks in the Galapagos Islands illustrate this quite well. So wind up concluding, as Darwin himself did, that whatever trait is common to the observed population is assumed to be the "best". This is roughly the same as declaring after the season is over that the team that won the Super Bowl was clearly going to win from what was observable at the beginning of the season. But the real problem is stasis. Horses arose from some unknown source in North America about 20,000 years ago. Part of the population migrated across the land bridge into Asia, and the original North American herds died out. In the 1500s, the Spanish brought European horses back to the Americas after an absence of 10-15,000 years. Based on DNA samples, wild (feral) horses in the American West are identical to remains of their extinct brothers. So, after travelling literally around the world while being subjected to one of the most sustained and intense selective breeding programs in history, horses didn't change at all. So how is stasis explained by Natural Selection?mahuna
January 9, 2014
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Mutations do provide information but it is natural selection that makes this specific to the niche that the organism resides. The selective pressure is clearly unique per niche with different filters indirectly adding information (the information of a forest is different from a filter of a niche in a sea vent). So would need to see more but as it is an expensive book that makes it inaccessible to the 99% so give it a few years to be free, or forgotten.Lincoln Phipps
January 9, 2014
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Ok thanks my teachers words not mine!Jaceli123
January 9, 2014
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wd400: because most DNA is junk anyway
We'll see about that in 10 years, shall we? I bet you there won't even be 20% "junk" left by then. Junk DNA will go down the same road the 180 human "vestigial organs" did in the past 100 years. SebestyenSebestyen
January 9, 2014
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wd400 at 10: Yoo hoo, read the OP. "Darwinism" and "Darwin and its followers" are other people's terms of choice this time out. (The latter is surely an error for "his followers.") People have NO idea how much we must pay those people to do that. It's shocking,really. ;)News
January 9, 2014
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wd400, Look man, don't insult my intelligence, alright. You're only counting the harmless mutations that the system allows by design. You are not counting the countless mutations that the system repairs automatically. We would all be dead without the gene repair mechanisms.Mapou
January 9, 2014
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CONTROVERSY!!! Does this mean SCIENTISTS were wrong before about selection being so important? What about all the science done backing up the old claims? How did they miss this?? If the old guard says NO will this guy be not a real scientist? When the court dat? Mutations or selection still are unlikely options for even trivial biological changes. Its over folks. They smell it too and are desperately looking for a out Just a wee bit of pressure from ID and YEC at the right point is bringing down this cards of error in our time. this forum will be a historical agent of change in future books documenting the end of Darwinian evolution. Kids will write about it in high school essaysRobert Byers
January 9, 2014
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Mapou, You and I both have about 60 new mutations. If mutations are nearly universally bad, why are we alive?wd400
January 9, 2014
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wd400:
It’s true the most mutations are harmless. Partly because most DNA is junk anyway, partly because many functional residues can change without altering their product’s behavior and partly because many changes in protein-coding genes don’t change amino acids.
This is complete moronic BS.Mapou
January 9, 2014
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Jaceli123, My understanding is that protein-coding genes are a very small percentage of the genome. Most genes are involved in regulation and adaptation. Minor changes in those genes can have catastrophic effects. The problem with mutations is so serious that all living organisms have special mechanisms whose job it is to repair changes caused by mutations. Unless a mutation is good for adaptation (pre-programmed in the genome), these gene repair subsystems have no way of knowing which mutation is good and which is bad. This defeats the most important engine of change/novelty in Darwinian evolution. I have said it many times. The Darwinian theory of evolution is for morons and liars with a political and ideological axe to grind.Mapou
January 9, 2014
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Jaceli123- So called silent mutations that your teacher talked about sometimes affect the protein. One of the reasons are the number of tRNAs per associated codon/ amino acid. One codon coding sequence may have more representative tRNAs and therefor those tRNAs are "johnny on the spot" with the amino acid- meaning the timing is right. However not all codons that code for the same amino acid are equally represented by the corresponding tRNAs. And if the tRNA is a little late in getting to the ribosome that messes up the folding process and the subsequent protein is malformed. Just sayin'...Joe
January 9, 2014
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(By the way, this about the thousandth change UD has to realise how silly it is to call modern evolutionary biology "Darwinism"... Not that I'm holding my breath...)wd400
January 9, 2014
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Jaceli123, It's true the most mutations are harmless. Partly because most DNA is junk anyway, partly because many functional residues can change without altering their product's behavior and partly because many changes in protein-coding genes don't change amino acids. Nut insertions and deletions in protein coding genes are likely to be deleterious. Because these sequences are "read" in sets of three (i.e. codons), an indel of size that is not divisible by three is guaranteed to garble any down-stream sequences.wd400
January 9, 2014
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Mapou:
The problem with random mutations is that over 99% of them are bad.
Most appear to be neutral, however the bigger problem is how do we know if all mutations are happenstance events? Evos just assume they are, except when they aren't (SOS response), because they don't know any better.Joe
January 9, 2014
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I do belive Stephen Meyer made the same point in Darwin's Doubt. Mutations must do the work of composing new genetic information not NS.RexTugwell
January 9, 2014
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@Mapou my teacher told me mutations can be harmless such as substitution and insertion show you can change a few letters but still have the same amino acid sequence.Jaceli123
January 9, 2014
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Does this explain the stasis in the fossil record along with the umpteen instances of convergence? As Mapou said, how can this idea overcome the problems with negative or almost neutral mutations? Or the problem of genetic entropy that Dr. John Sanford has researched? I guess this does away with the need for a long series of small positive changes that provide enough of a benefit to the organism that they are selected for. I can certainly see the appeal of this new idea as the old one demands huge amounts of time. Plus, there really is no experimental support for the idea that a long series of small yet positive changes leading to new genes/organs/abilities, etc. is possible. Sounds great in theory, but does such a pathway even exist? No one really knows!tjguy
January 9, 2014
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The problem with random mutations is that over 99% of them are bad. So, to get good mutations you need extremely large populations. But when you look at the history of complex species that have supposedly undergone extreme levels of mutations (e.g., humans), their populations were very small in the past compared to now.Mapou
January 9, 2014
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Ernst Mayr:
Natural selection- The process by which in every generation individuals of lower fitness are removed from the population- Mayr "What Evolution Is" The first step in selection, the production of genetic variation, is almost exclusively a chance phenomenon except that the nature of the changes at a given locus is strongly constrained. Chance also plays an important role even at the second step, the process of elimination of less fit individuals. Chance may be particularly important in the haphazard survival during periods of mass extinction. Ibid
and
“Natural selection is the simple result of variation, differential reproduction, and heredity—it is mindless and mechanistic.”- UC Berkley on Evolution
However I think I see what he is saying. NS was supposed to be this great designer mimic. However if the variation happens and accumulates for some future purpose, in the absence of selection, and then badda-bing, badda-boom, in close to one fell swoop you may have something.Joe
January 9, 2014
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Well, the prof seems to think otherwise. We'll see.News
January 9, 2014
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Natural selection includes mutation- random mutations are one of the inputs, ie drivers, of natural selection. But true you can have random mutation without natural selection. And as Dr Spetner said back in 1997, only via our ignorance can we say that gene duplication is a darwinian mechanism.Joe
January 9, 2014
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