Cell biology Evolution Intelligent Design

Researchers: Novel mechanism protects mitochondrial DNA

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From Eurekalert:

Researchers at the University of Eastern Finland have discovered a novel mechanism safeguarding mitochondrial DNA. The study, published in PNAS earlier this week, was carried out in close collaboration with research groups from CBMSO in Madrid, Spain, and Umeå University in Sweden. A central part of the protective mechanism is an unusual enzyme, PrimPol, which can re-initiate mitochondrial DNA replication after damage.

Besides nuclear genomic DNA, mitochondria also contain their own small genomes, mitochondrial DNA (mtDNA), which encodes for thirteen essential parts of the cellular respiration machinery. mtDNA is especially vulnerable to oxidative damage as it is located close to the free radical producing mitochondrial electron transport chain. Cells protect their mitochondria by repairing mtDNA as well as constantly making new copies of it to replace the damaged molecules. Although cells are able to tolerate DNA damage, problems might arise when the DNA is replicated. Certain types of damage can stall the replication machinery before all of the genome has been replicated. This can result in double-strand breaks in DNA, resulting in the loss of partially replicated parts of the genome. In mitochondria this partial loss, or deletion, causes dysfunction of the cellular respiration and is the driving pathological mechanism behind many mitochondrial diseases but also responsible for aging associated decline of cell function.

Researchers were able to show that a primase enzyme PrimPol can generate a new primer adjacent to the damaged DNA sequence and re-initiate stalled replication in mitochondria. PrimPol itself is a highly unusual, structurally ancient primase, which can synthetize DNA primers in contrast to RNA primers synthetized by all other primases in our cells. Not only does the new study change our perceptions of PrimPol’s functions, it also helps us to understand the basic mechanisms of mtDNA maintenance.
More.

Of course, novel mechanisms just pop into distance any old time when “natural selection” needs them. That’s why there are so many Boltzmann brains floating around.

See also: And now, the internet of cells

5 Replies to “Researchers: Novel mechanism protects mitochondrial DNA

  1. 1
    Axel says:

    Wow! Not just a mechanism, but a novel one. It’s just like evolution – always surprising its disciples. Isn’t random chance resourceful, and ‘genius-level’ imaginative !

    Animism writ large.

  2. 2
    Mung says:

    Indeed. Instead of inheritance of acquired traits, it’s acquisition of traits that would be nice to inherit.

  3. 3
    Axel says:

    A trifling distinction, esteemed Mung. (cough) (cough)

  4. 4
    J-Mac says:

    First Restriction Enzymes now this… Endosymbiosis looks like a miracle of evolution more and more every day…lol

    If this progresses even further, materialists are not going to object to the possibility of multiple origins of life. They are going to pretend that evolution predicted it… 😉

  5. 5
    Dionisio says:

    Here’s the original paper referenced in this OP:

    http://www.pnas.org/content/ea.....1705367114

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