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Add to the spellcheck “epitranscriptome”


From ScienceDaily:

Paper. (paywall)Our genome is made up of 6,000 million pieces of DNA that combine four “flavors”: A, C, G and T (Adenine, Cytosine, Guanine and Thymine). It is our Alphabet. But to this base we must add some regulation, just like the spelling and grammar of that alphabet: this is what we call Epigenetics.

“In epigenetics, there there are “accents,” called DNA methylation, which means having a C or a methyl-C. The first one usually means that a gene is expressed and active, while the second one implies that a gene is silent and inactive. Our DNA “speaks” when it produces another molecule called RNA (Ribonucleic Acid). Until very recently, it was believed that this molecule was only a poorly regulated intermediate capable of producing proteins (such as insulin, hemoglobin and others) under DNA’s orders. “Today, an article published in Cancer Discovery by Manel Esteller, Director of the Epigenetics and Cancer Biology Program of Bellvitge Biomedical Research Institute (IDIBELL), ICREA Researcher and Professor of Genetics at the University of Barcelona, explains that this RNA also has its own spelling and grammar, just like DNA. These “epigenetics of RNA” are called epitranscriptome.” – Manel Esteller, Pier Paolo Pandolfi. The Epitranscriptome of Noncoding RNAs in Cancer. Cancer Discovery, 2017; DOI: 10.1158/2159-8290.CD-16-1292More.

So not only does DNA have spelling and grammar but so does RNA, as a sort of cognate language, instead of being “a poorly regulated intermediate capable of producing proteins.”

File under: Why the sea is boiling hot.

See also: Epigenetic change: Lamarck, wake up, you’re wanted in the conference room!

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gpuccio: At this pace of biology-related research papers and discoveries appearing online, the overwhelming saturation of information will make the so-called "big data" problems in physics and astronomy look unimpressive. :) Dionisio
Dionisio: Yes, it seems it's a hot topic! :) gpuccio
gpuccio @4: In the link you provided they also list this paper: https://www.ncbi.nlm.nih.gov/pubmed/27345446 Which is here: http://onlinelibrary.wiley.com/doi/10.1002/wrna.1375/abstract;jsessionid=EB37C399E02EC62266876F16A4E9E152.f02t02 Which apparently is cited by this paper: https://www.ncbi.nlm.nih.gov/pubmed/27351916 Which is here: http://www.tandfonline.com/doi/full/10.1080/15476286.2016.1203504 Which apparently is cited by this paper: https://www.ncbi.nlm.nih.gov/pubmed/27802489 Which is here: http://iovs.arvojournals.org/article.aspx?articleid=2578865 Dionisio
gpuccio @4: It seems like the paper you referred to is cited by this paper:? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303883/ Which is here: http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2017.2319 Dionisio
gpuccio, That's a very interesting paper. Thanks. Dionisio
Alfred Russel, Dionisio: Here is another recent review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167638/ gpuccio
Here's another related paper: http://science.sciencemag.org/content/352/6292/1408 Dionisio
Did this term appear 5 years ago? http://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-10-175 And last year here: http://rnajournal.cshlp.org/content/22/2/169 Dionisio
Interesting paper abstract. Thanks. Dionisio

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