David Coppedge on cell division as another “hurdle for evolution”

_{Denyse O'Leary

May 8, 2022

Cell biology, Intelligent Design}

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How do cells maintain integrity during division?:

When a stem cell divides, one daughter cell must maintain its stemness (i.e., ability to differentiate into any cell type) while the other specializes. Therein lies another truckload of requirements for coordinated action that, if it goes awry, can spell disaster for an animal or human. Watch this subject grow into a huge problem for evolutionary theory.
Researchers at University of California at Riverside investigated what happens when stem cells divide and specialize. UCR’s reporter Iqbal Pittawala describes how “genome organization influences cell fate.”
“Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.”
The two daughter cells face a massive organization problem. Even though they contain the same DNA code, they will take on separate roles in the cell. This means that the accessibility of genes between the two cells must radically differ.
Dave Coppedge, “Cell Fate: Another Hurdle for Evolution” at Evolution News and Science Today (May 6, 2022)

Actually, it is only a problem if ruining the careers of those who engage in an honest discussion is no longer an available option.

Comments

Martin_r PS: and, obviously, genes always stays at the same position … they don’t move elsewhere … otherwise the gene map would be useless … so i was wondering, when some retro virus inserts its DNA into our DNA, will this gene map become useless ?
Not really. Cell is "smarter" than you think. If move a gene/sequence in other place will make a different bookmark (editing) so when will need it will go directly to the new bookmark(address) https://www.ed.ac.uk/mrc-human-genetics-unit/news-and-events/news-2014/gene-relocation
but there is a mechanism for creating new DNA that has no function.
I don't think so. To know that you have to decode all processes in the cell but while they continue to do experiments that means they don't know how it works.Lieutenant Commander Data_{May 10, 2022
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It has everything to do with “junk DNA.”
It has nothing to do with junk DNA is probably a more accurate answer. Aside: I have recommended that the term "junk DNA" be discarded. It is a meaningless term. There does appear to be some DNA that has no function. Maybe that will change but there is a mechanism for creating new DNA that has no function.jerry_{May 10, 2022
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Hickson @19
Non-coding DNA is not Junk DNA. This is basic stuff, folks
Basic stuff? Look here, ScienceDaily article (2021):
Despite the prevalent view that some 98% of our genome is junk DNA, new research shows that one piece of junk DNA -- the promoter of a virus-based transposon -- plays a critical role in cell proliferation and timing of embryo implantation in mice. The group found virus-based promoters linked to genes involved in development in other mammals, including humans, suggesting that transposons have been broadly repurposed for important regulatory roles. https://www.sciencedaily.com/releases/2021/10/211018140504.htm
it looks like, your guys (Darwinists) don't know 'basic stuff'.martin_r_{May 10, 2022
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Marker: Cell division – what regulates it? What causes it? What makes it work? You seem not interested in even trying to find answers for your questions. It's quite easy to start with something like this: https://en.wikipedia.org/wiki/Cell_division And if some subtopic attracts your attention then follow the links to the pertinent research cited.JVL_{May 10, 2022
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Non-coding DNA is not Junk DNA. This is basic stuff, folks.Fred Hickson_{May 10, 2022
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Darwinists and Junk DNA: If there won't be any Junk DNA, in other words, if the whole genome has a function, a Darwinist would say: This makes lots of sense, because natural selection would remove any non-functional DNA, why to waste energy to keep something which isn't need ... If there is Junk DNA, for Darwinism, it is also OK, because this is an evidence for blind unguided evolution, and "junk" accumulated through the years ... For Darwinists it is a win-win situation ... as always ...martin_r_{May 10, 2022
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Jerry, You still don't understand? Cell division - what regulates it? What causes it? What makes it work? Scientists still don't know a lot but they'll put the answer ahead of the research. Evolution is the default answer no matter what the question is. 'It all happened by itself' is the default answer before examining the organism, whichever organism that is. It has everything to do with "junk DNA."marker_{May 10, 2022
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Junk DNA is a favorite distraction guaranteed to create all sorts of irrelevant diversion. The answer to what is junk is, some is probably not junk, some is probably junk. The question is what is the percentage of each? Nothing to do with the OP. Unless one has evidence that this is where information about cell formation takes place. Then why do other organisms have different junk DNA? Somehow that doesn’t come up. But again, this OP has nothing to do with junk DNA.jerry_{May 10, 2022
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ET @14
Anyone saying the bulk of our or any genome is junk, has to tell us how blind and mindless processes produced spools to organize that junk and functional sequences to maintain viable organisms.
Very good point ... I have asked something similar in my other post: How a cell knows, what is the position/location of a particular gene ... first, which chromosome, then which arm of the chromosome, and then what is the exact position on this arm ... ( biologists had to create a gene map) PS: and, obviously, genes always stays at the same position ... they don’t move elsewhere ... otherwise the gene map would be useless ... so i was wondering, when some retro virus inserts its DNA into our DNA, will this gene map become useless ?martin_r_{May 10, 2022
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Anyone saying the bulk of our or any genome is junk, has to tell us how blind and mindless processes produced spools to organize that junk and functional sequences to maintain viable organisms. Larry Moran can't do it. He is the worst of the cowards. No one should listen to what he has to say because he ignores the elephant standing on his chest.ET_{May 10, 2022
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basic errors (non-coding DNA is not junk DNA)
:) This is how a religious type of evolutionist looks like. Hey, wake up we are not in 1850 to believe in self-organisation of matter that Pasteur debunked in 1860(food spoiled because of contamination by invisible bacteria, not because of spontaneous generation. )Back then they really believed that worms appear from rotten flesh or flies from rotten fruits so make sense for Darwin fans to think a cell need only gene for proteins , who need regulation of protein?Sandy_{May 10, 2022
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Marker:
I sure did
That surprises me. I read the linked articles and the first two seem uncontroversial. The third makes a couple of basic errors (non-coding DNA is not junk DNA) and the fourth attacks a strawman version of Encode. 8-12 % of the human genome is generally agreed as essential (including non-coding DNA) and 75% roughly is junk-DNA. There's questions on the remainder. Another opportunity for ID researchers.Fred Hickson_{May 9, 2022
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Oh, man Dawkins didn't apologized for this yet, just jumped from:
"The simplest way to explain the surplus DNA :) is to suppose that it is a parasite, or at best a harmless but useless passenger, hitching a ride in the survival machines..."(The selfish gene)
to
"it's exactly what a darwinist would hope for "(Dawkins).Priceless. https://www.youtube.com/watch?v=LTZc7zc-nmU
Back in 2012 ENCODE talked about at least 80% functional based on their data. This is a undeniable fact . Only religious darwinists dispute that. https://www.nature.com/articles/nature11247.pdf
"The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research."
Lieutenant Commander Data_{May 9, 2022
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I sure did. More: https://medicine.yale.edu/news/yale-medicine-magazine/article/junk-no-more/marker_{May 9, 2022
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@ Marker Did you read the articles you linked to?Fred Hickson_{May 9, 2022
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Really? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014423/ https://news.wsu.edu/news/2021/07/23/research-identifies-potential-role-junk-dna-sequence-aging-cancer/ https://www.drugdiscoverytrends.com/genomics-researchers-say-junk-dna-key-to-advancing-medicine/marker_{May 9, 2022
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From Larry Moran's blog Sandwalk
Most lncRNAs are junk A hard-hitting review will be published in Annual Review of Genomics and Human Genetics. It shows that the case for large numbers of functional lncRNAs is grossly exaggerated. A long-time Sandwalk reader (Ole Kristian Tørresen) alerted me to a paper that's coming out next October in Annual Review of Genomics and Human Genetics. (Thank-you Ole.) The authors of the review are Chris Ponting from the University of Edinburgh (Edinburgh, Scotland, UK) and Wilfried Haerty at the Earlham Institute in Norwich, UK. They have been arguing the case for junk DNA for the past two decades but most of their arguments are ignored. This paper won't be so easy to ignore because it makes the case forcibly and critically reviews all the false claims for function.
Seversky_{May 9, 2022
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Here's an article written for the layperson that might be worth a look https://www.quantamagazine.org/the-complex-truth-about-junk-dna-20210901/ I've read it and it's quite a helpful non-technical summary. Lots of room for ID proponents to find the function in the junk. Have at it, guys and gals.Fred Hickson_{May 9, 2022
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So-called "junk DNA" was a decision made before all of the research was in. It turns out that these non-coding (for proteins) regions have functions. https://www.eurekalert.org/news-releases/945286marker_{May 9, 2022
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Same DNA carries out different roles from parent to daughter cell. Even if mutation and selection could account for the code, which it can't, it then has to make that differentiation from something other than the DNA.Silver Asiatic_{May 9, 2022
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Is this just more proof that the mechanism for development and thus Evolution lies not in DNA? Where is this mechanism?jerry_{May 9, 2022
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Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology ...
A fundamental problem just understanding them? No way. We already know that this evolved, so we clearly must have understood all of this by now. "UCR’s reporter Iqbal Pittawala" is just a journalist so he's not an expert and obviously doesn't understand.
The two daughter cells face a massive organization problem. Even though they contain the same DNA code, they will take on separate roles in the cell.
Back to earth ... clearly it is a massive problem for evolution. Just basic cell division. I am reminded of the video on the structure of cell walls that allow nutrients to pass through but block toxins. Darwin can't even give us a single cell.
Actually, it is only a problem if ruining the careers of those who engage in an honest discussion is no longer an available option.
So far, no problem at all. There's no debate. No weaknesses in evolutionary theory. Evolution is more certain than gravity.Silver Asiatic_{May 9, 2022
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As Mr. Spock would say... Fascinating. Andrewasauber_{May 9, 2022
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