In the following article, ask yourself if “the protein tape of life may be largely reproducible and even predictable,” what this means for the testability of evolutionary theory and ID should nature be constituted so that no Darwinian pathways exist for certain proteins.
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
Daniel M. Weinreich, Nigel F. Delaney, Mark A. DePristo, Daniel L. Hartl
Five point mutations in a particular ÃƒÅ¸-lactamase allele jointly increase bacterial resistance to a clinically important antibiotic by a factor of 100,000. In principle, evolution to this high-resistance ÃƒÅ¸-lactamase might follow any of the 120 mutational trajectories linking these alleles. However, we demonstrate that 102 trajectories are inaccessible to Darwinian selection and that many of the remaining trajectories have negligible probabilities of realization, because four of these five mutations fail to increase drug resistance in some combinations. Pervasive biophysical pleiotropy within the ÃƒÅ¸-lactamase seems to be responsible, and because such pleiotropy appears to be a general property of missense mutations, we conclude that much protein evolution will be similarly constrained. This implies that the protein tape of life may be largely reproducible and even predictable.