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Jumping genes regulate the human brain’s development

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Especially before birth:

The researchers identified two KZFPs [Krüppel-associated box-containing zinc finger proteins] as specific only to primates, and found that they are expressed in specific regions of the human developing and adult brain. They further observed that these proteins kept controlling the activity of transposable elements — at least in neurons and brain organoids cultured in the lab. As a result, these two KZFPs influenced the differentiation and neurotransmission profile of neurons, as well as guarded these cells against inflammatory responses that were otherwise triggered if their target transposable elements were left to be expressed.

“These results reveal how two proteins that appeared only recently in evolution have contributed to shape the human brain by facilitating the co-option of transposable elements, these virus-like entities that have been remodeling our ancestral genome since the dawn of times,” says Didier Trono. “Our findings also suggest possible pathogenic mechanisms for diseases such as amyotrophic lateral sclerosis or other neurodegenerative or neurodevelopmental disorders, providing leads for the prevention or treatment of these problems.”

Ecole Polytechnique Fédérale de Lausanne, “‘Jumping’ DNA regulates human neurons” at ScienceDaily

Paper. (open access)

Note: “these virus-like entities that have been remodeling our ancestral genome since the dawn of times,” says Didier Trono.” Right. We are told that many of the French have no use for lumpen-Darwinism. One can see why not.

Doubter @1: Excellent point! Agree. We all should keep in mind that the more we know about the intricacies of the information-processing systems discovered within biology, more is there for us to investigate. It’s starting to look like a never-ending story. As some outstanding questions get answered, newer questions pop up. We ain’t seen nothin’ yet. :) jawa
Still, it's apparent that the information source during development for the detailed incredibly intricate and complicated design of the brain, consisting of billions of neurons and trillions of synaptic junctions, is unknown. To speak nothing of the detailed developmental construction plans for the rest of the body. It seems as if all the developmental regulatory pathways that have been discovered influence development but don't specify it in detail. The detailed design plan is located where? There doesn't seem to be anywhere enough information storage space in the DNA of the genome. This inconvenient fact (to Darwinist genetic determinism) is always conveniently glossed over by evolutionary biologists and other researchers. doubter

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