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Metabolic proteins relocate to jumpstart an embryo

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From Ann Gauger at at Evolution News & Views:

Yesterday started out as an ordinary Tuesday. Then I set out to read a recent paper published in the journal Cell, “Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation,” by R Nagaraj et al. It reported something rather odd that caught my eye. Very early embryos (at the two- or four-cell stage in mouse or human respectively) undergo a critical transition: they have to go from relying on RNAs and proteins loaded into the egg before fertilization by the mother, to making their own RNA and protein.

The phenomenon is called embryonic genome activation. In order to activate their genomes, embryos have to remove maternal and paternal epigenetic modifications and create new ones appropriate to the embryonic genome.

Stop and think. That’s remarkable — there is a fair amount of information being imparted to the genome by these epigenetic changes, and we know little about how that happens. We do know according, to the authors, that More.

We know that we are in the midst of an information revolution; we just don’t know how deep and wide it is.

It’s a good thing that ideas are immaterial because we will not need a special Recycle box for popular evolution pieties.

See also: Epigenetics: Embryos receive parent-specific layers of information, study shows

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3 Replies to “Metabolic proteins relocate to jumpstart an embryo

  1. 1
    Dionisio says:

    Very interesting topic.

  2. 2
    bornagain77 says:

    As to embryological development, starting around the 40:00 minute mark of the following powerpoint presentation, I was pleasantly surprised by Jonathan Wells’s observation, via Richard Sternberg, that information must be coming in to the developing embryo ‘from the outside’ from a ‘non-material’ source in order to explain the changing form of the embryo:

    Design Beyond DNA: A Conversation with Dr. Jonathan Wells – video (40:00 minute mark) – January 2017
    https://youtu.be/ASAaANVBoiE?t=2405

    Besides that surprising fact, the entire powerpoint presentation by Dr. Wells is well worth watching in full since it undermines the ‘central dogma’ of Darwinian evolution, i.e. “DNA makes RNA makes protein makes us”, is shown to be incorrect at every step.

  3. 3
    bornagain77 says:

    Also of related note to embryological development:

    From Genome to Body Plan: A Mystery – January 24, 2017
    Excerpt: Decoding genomes has been one of the most important advances of the last sixty years, but it’s really just a start of a far larger mystery: the mystery of development.,,,
    “A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. “,,,
    The authors marvel at how “organoids” emerge from induced pluripotent stem cells.,,, After thinking about it, they admit that more must be going on.
    ,,,”Organoid formation itself demonstrates that cells can become organized in the absence of predetermined long-range external patterning influences such as morphogen gradients or mechanical forces, which are a cornerstone of classic developmental biology. This unexpected lack of requirement for long-range pre-patterning has led to organoid formation being described as an example of ‘self-organization’, which is defined classically as the spontaneous emergence of order through the interaction of initially homogeneous components.”,,,
    http://www.evolutionnews.org/2.....03451.html

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