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Researcher: Viruses are “smart” but the human immune system is smarter


How human RNA resists viral takeover:

In the Muller Lab, student researchers work with Muller studying how Kaposi sarcoma-associated herpesvirus (KSHV) hides for years inside the human body before seeking to gain control over human gene expression to complete the viral infection. At that point, people with a weakened immune system may develop Kaposi sarcoma cancer lesions in the mouth, skin or other organs.

The researchers use genome-wide sequencing, post-transcriptional sequencing and molecular biology to examine how the human cell or the virus knows how to prevent degradation.

“Viruses are very smart, that’s what I love to say,” Muller says. “They have lots of strategies to stick around, and they don’t do a lot of damage for a very long time, because that’s one way to hide from the immune system.

“But then, at some point — many, many years later — they reactivate. The way they do this is by triggering a massive RNA degradation event where the virus will wipe out the mRNA from the cell. That means the human system can no longer express the proteins that it needs to express, and that means also that a lot of resources are suddenly available for the virus.”

How and why some RNA are able to escape the viral degradation are questions Muller’s team — including lead author and graduate student Daniel Macveigh-Fierro and co-authors and undergraduates Angelina Cicerchia, Ashley Cadorette and Vasudha Sharma — has been investigating.

“We show that RNA that escape have a chemical tag on them — a post-transcriptional modification — that makes them different from the others,” Muller explains. “By having this tag, M6A, they can recruit proteins that protect them from degradation.”

University of Massachusetts Amherst, “Research advances knowledge of the battle between viruses and human cells” at ScienceDaily (February 18, 2022)

The paper requires a subscription.

It’s becoming harder for researchers to claim that there is no intelligence in nature. That’s probably why so many of them are embracing panpsychism. They want a way to include intelligence in nature without an intelligence outside nature. It won’t work but at least it makes more sense in relation to the evidence.

You may also wish to read: Neuroscientist: Even viruses are intelligent Antonio Damasio says, in the excerpt from his new book, that — based on the evidence — we cannot deny viruses “some fraction” of intelligence. Researchers who study viruses, including the one that causes COVID, note similarities between viral strategies and those of insects and animals.

Marco Del Giudice came up with a brilliant question on this subject. Did our nervous system develop 'electronic countermeasures' against viral control? When viruses tried to pull the seed-pod trick, turning us into mobile carriers, did the brain 'encyst' those imposed behaviors in a separate space? http://polistrasmill.blogspot.com/2019/08/opsec-vs-virus.html polistra
They want a way to include intelligence in nature without an intelligence outside nature. I can conceive of an intelligence independent of and superior to nature but I can't conceive of it being outside of nature. groovamos
Claiming that the immune system even EXISTS is "dangerous misinformation". CDC and Fauci have been INSTRUCTING us that immunity is a Trump conspiracy theory. Saying that it's smarter than viruses is LETHAL SUPERMISINFORMATION! (In other words, obvious and ordinary pre2020 truth.) polistra
The immune system is extremely complicated so we are a prisoner of what other say. A book I am almost finished with is a case in point. It’s title is “Immune” by Phillip Dettmer. https://www.philippdettmer.net/ I only have a vague understanding of the immune system since it is so complicated. So I plan on reading it a couple more times going through it piecemeal til I understand a topic before going on to the next section. Dettmer has published several cartoons to try to make this more understandable. Here is his YouTube channel https://www.youtube.com/c/inanutshell/featured One short one on the immune system https://www.youtube.com/watch?v=lXfEK8G8CUI jerry

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