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Transcription Factors Controlling Transcription Factors

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Researchers at the University of Warwick have found another round of “conserved” non coding sequences, this time in the four plant species: the papaya, poplar, Arabidopsis and grape. And if the these similar DNA sequences are found in such disparate species, then the sequences must have been present in a very distant, and much simpler, common ancestor. The problem these CNS’s are apparently rather clever. Not only do they appear to be regulating gene expression by influencing transcription factor binding, but they many of the genes regulated by these sequences are themselves transcription factors. As one researcherexplains:  Read more

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'It's becoming extremely problematic to explain how the genome could arise and how these multiple levels of overlapping information could arise, since our best computer programmers can't even conceive of overlapping codes. The genome dwarfs all of the computer information technology that man has developed. So I think that it is very problematic to imagine how you can achieve that through random changes in a code.,,, More and more it looks like top down design and not just bottom up chance discovery of making complex systems.' - Dr. John Sanford http://www.youtube.com/watch?v=YemLbrCdM_s Poly-Functional Complexity equals Poly-Constrained Complexity https://docs.google.com/document/d/1xkW4C7uOE8s98tNx2mzMKmALeV8-348FZNnZmSWY5H8/editbornagain77
December 8, 2012
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Today's belief in ineluctable certainty is the true innovation-killer of our age. In this environment, the best an audacious manager can do is to develop small improvements to existing systems, climbing the hill, as it were, toward a local maximum, trimming fat, occasionally eking out the occasional tiny innovation - like city planners painting bicycle lanes on the streets as a gesture toward solving our energy problems. Any strategy that involves crossing a valley - accepting short-term losses to reach a higher hill in the distance - will soon be brought to a halt by the demands of a system that celebrates short-term gains, tolerates stagnation, but condemns anything else as failure. In short, a world where big stuff can never get done. - Neal Stephenson
Sound familiar?Mung
December 8, 2012
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