Miller and Urey produced simple amino acids but then nothing happened. Apparently, the containers you use to try to make life in a test tube matter:
In the years following the original work, several limitations curbed excitement over its result. The simple amino acids did not combine to form more complex proteins or anything resembling primitive life. Further, the exact composition of the young Earth did not match Miller’s conditions. And small details of the setup appear to have affected the results. A new study published last month in Scientific Reports investigates one of those nagging details. It finds that the precise composition of the apparatus housing the experiment is crucial to amino acid formation.
The highly alkaline chemical broth dissolves a small amount of the borosilicate glass reactor vessel used in the original and subsequent experiments. Dissolved bits of silica permeate the liquid, likely creating and catalyzing reactions. The eroded walls of the glass may also boost catalysis of various reactions. This increases total amino acid production and allows the formation of some chemicals which are not created when the experiment is repeated in an apparatus made of Teflon. But, running the experiment in a Teflon apparatus deliberately contaminated with borosilicate recovered some of the lost amino acid production.Tom Hartsfield, “What the famous Miller-Urey experiment got wrong” at BigThink (November 21, 2021)
When life got started, they always used Teflon.
You may wish to read: The Science Fictions series at your fingertips – origin of life What we do and don’t know about the origin of life.