Latest: Intolerance of smoke killed the Neanderthals
From Colin Barras at New Scientist: Where there’s fire there’s often smoke – which might have been bad news for Neanderthals and other ancient hominins. Modern humans carry a genetic mutation that reduces our sensitivity to cancer-causing chemicals found in wood smoke. But Neanderthals and Denisovans apparently lacked the mutation. … The team inserted human and Neanderthal versions of the AHR gene into animal cells in the lab and examined how the cells responded when exposed to these carcinogens. The Neanderthal version proved to be far more likely to cause the production of enzymes that induce a toxic effect. “We were surprised that the differences between the two were so large,” says Perdew. For some compounds there was a 1000-fold Read More ›