Cell biology

Onlookers, Geno concludes for the moment with FAQ’s: ____________________ Geno: >> A Testable ID Hypothesis: Front-loading, part C In the last two articles on front-loading, I explained what the front-loading hypothesis is all about and some research questions we can ask from a front-loading perspective. This article will be an FAQ about the front-loading hypothesis. So, without further introduction, let’s begin (note: some of the content of this FAQ can be found in the previous two articles). What is front-loading? “Front-loading is the investment of a significant amount of information at the initial stage of evolution (the first life forms) whereby this information shapes and constrains subsequent evolution through its dissipation. This is not to say that every aspect of Read More ›

Genomicus continues his presentation of the front-loading hypothesis: ___________ Geno: >>In my previous article on the subject of front-loading, I described the front-loading hypothesis and what it proposes. I outlined three testable predictions generated by the front-loading hypothesis. In this article, we’ll see how the front-loading hypothesis can lead us to numerous research questions, and this, in turn, will allow us to establish a better picture about the history of the origin and development of biological complexity. There are probably dozens of research questions that we can ask as a result of the front-loading hypothesis, so I’ll only cover some of them here. How could molecular machines and systems be front-loaded? An interesting question from a front-loading perspective is how Read More ›

For some months now, I have been having a behind the scenes correspondence with a regular viewer of UD, whom we shall call EP. He works with industrial robots, and has been fascinated by the way the ribosome works as a nano-scale automated machine cell. Accordingly, a process sequence diagram (‘map”) has been developed, based on accessible descriptions of the ribosome in action. The result is a fascinating look at the ribosome as industrial robot work-cell. (The tRNA’s are molecular scale position-arm devices with a universal CCA coupler — yup, the AA bond is universal, it is the loading enzyme that sets up which tRNA gets what AA — to load and click AAs to a protein chain.) So, enough Read More ›

Sometimes, seeing is believing. Here is a nice, short summary of the kinesin microtubule highway “walking truck” protein in action: [youtube lLxlBB9ZBj4] This vid gives a bit of context: [youtube 8RULvE9rw6Y] Especially notice the role played by Brownian motion, and that played by ATP. So, post turkey and pudding vid no 3: ATP Synthase in action: [youtube KU-B7G6anqw] Walking trucks in the cell, fuelled by batteries made in a molecular factory that uses a nanotech motor  . . . And, a highway network that has to go where it is needed, with need for directions — that delivery truck has to know where to go, when! And the best explanation for all of this functionally specific, complex organisation and required Read More ›

Video animation of RNA interference (RNAi)