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Biological selection must occur at the nucleotide-sequencing molecular-genetic level

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David L. Abel, editor of The First Gene, writes in Chapter 7:

The Genetic Selection (GS) Principle

Abstract. The GS (Genetic Selection) Principle states that biological selection must occur at the nucleotide-sequencing molecular-genetic level of 3’5′ phosphodiester bond formation. After-the-fact differential survival and reproduction of already-programmed, already-living phenotypic organisms (natural selection) does not explain polynucleotide sequence prescription and coding. All life forms depend upon exceedingly-optimized genetic algorithms. Biological control requires selection of particular physicodynamically indeterminate configurable switch settings to achieve potential function. This occurs largely at the level of nucleotide selection, prior to the realization of any isolated or integrated biofunction. Each selection of a nucleotide corresponds to a quaternary (four-way) switch setting. Formal logic gates must be set initially that will only later determine folding and binding function through minimum Gibbs-free energy sinks. The fittest living organisms cannot be favored until they are first programmed and computed. The GS Principle distinguishes selection of existing function (undirected natural selection) from selection for potential function (formal selection at decision nodes, logic gates and configurable switch settings).

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Dr. Sanford makes the point, in this following video, that natural selection is far removed from the nucleotide level;
Genetic Entropy - Dr. John Sanford - Evolution vs. Reality - video http://vimeo.com/35088933

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