Isn’t it the case that a great deal of (lights and fanfare!) evolution we hear about is turning out to be devolution?:
Sales-Lee et al. show that the ancestral spliceosome was complex and the intronreduced yeast S. cerevisiae lost dozens of spliceosomal proteins maintained in intron-rich fungi and humans. Functional and proteomic analysis in the intron-rich yeast C. neoformans reveals roles for these proteins in splicing fidelity and uncovers functional modules.Sales-Lee et al., Coupling of spliceosome complexity to intron diversity, Current Biology (2021), https://doi.org/10.1016/j.cub.2021.09.004 (forthcoming November 22, 2021)
The paper is open access.