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3-D structures of active DNA now available

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Mouse cell with 20 chromosomes colored differently/U Cambridge, MRC Lab

From ScienceDaily:

Most people are familiar with the well-known ‘X’ shape of chromosomes, but in fact chromosomes only take on this shape when the cell divides. Using their new approach, the researchers have now been able to determine the structures of active chromosomes inside the cell, and how they interact with each other to form an intact genome. This is important because knowledge of the way DNA folds inside the cell allows scientists to study how specific genes, and the DNA regions that control them, interact with each other. The genome’s structure controls when and how strongly genes — particular regions of the DNA — are switched ‘on’ or ‘off’. This plays a critical role in the development of organisms and also, when it goes awry, in disease.Paper. (paywall) – Stevens, TJ et al. 3D structures of individual mammalian genomes studied by single-cell Hi-C. Nature, 3 March 2017 DOI: 10.1038/nature21429More.

It also makes it easier to discuss genetics in a non-reductive way.

See also: Cod gene puzzle: At least no one is claiming it is “junk DNA”

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Related? http://www.pnas.org/content/113/12/E1663.long Dionisio
By studying genes regulated by pluripotency factor and nucleosome remodelling deacetylase (NuRD), we illustrate how the determination of single-cell genome structure provides a new approach for investigating biological processes.
new approach for investigating biological processes? new approach for biology research? in the second half of the second decade of the 21st century? any certainty that this is it? there yet? :) Dionisio
3D structures of individual mammalian genomes studied by single-cell Hi-C Tim J. Stevens, David Lando, Srinjan Basu, Liam P. Atkinson, Yang Cao, Steven F. Lee, Martin Leeb, Kai J. Wohlfahrt, Wayne Boucher, Aoife O’Shaughnessy-Kirwan, Julie Cramard, Andre J. Faure, Meryem Ralser, Enrique Blanco, Lluis Morey, Miriam Sansó, Matthieu G. S. Palayret, Ben Lehner, Luciano Di Croce, Anton Wutz, Brian Hendrich, Dave Klenerman & Ernest D. Laue Nature (2017) doi:10.1038/nature21429 Received 18 March 2016 Accepted 26 January 2017 Published online 13 March 2017
Very interesting paper. Thanks. BTW, why did it take almost a whole year to publish it? Dionisio

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