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Large-scale study: Every tissue has its own pattern of active alleles

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From ScienceDaily:

Every gene in (almost) every cell of the body is present in two variants — so called alleles: one is deriving from the mother, the other one from the father. In most cases both alleles are active and transcribed by the cells into an RNA message. However, for a few genes, only one allele is expressed, while the other one is silenced. The decision whether the maternal or the paternal version is shut down occurs early in embryonic development — one reason, why for long it was thought that the pattern of active alleles is nearly homogeneous in the various tissues of the organism.

The new study (DOI:10.7554/eLife.25125), where CeMM PhD Student Daniel Andergassen is first author (now a PostDoc at Harvard University), uncovers a different picture. By performing the first comprehensive analysis of all active alleles in 23 different tissues and developmental stages of mice, the team of scientists revealed that each tissue showed a specific distribution of active alleles. Paper. (public access) – Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. eLife, 2017; 6 DOI: 10.7554/eLife.25125 More.

It happens differently in different tissues of the body but it all somehow works. Hmmm.

See also: Did algae trigger complex cells before 650 million years ago?

Comments
Allelome? "Genomic imprinting is an epigenetic process through which genes are expressed in a parent-of-origin-specific manner." "widespread and complex mechanism"? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539102/pdf/41598_2017_Article_7514.pdf"Dionisio
August 22, 2017
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"...cluster size varies dynamically during development and can be substantially larger than previously thought, with the Igf2r cluster extending over 10 Mb in placenta." "...tissue-specific silencing seen for XCI and imprinted silencing may be explained by actions on tissue-specific enhancers. " "...the size of an imprinted cluster in a particular tissue correlated with size of the region showing parental-allele specific H3K27ac enrichment." "...all types of allele-specific expression that we observed may be mediated by allele-specific actions on enhancers." Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. eLife, 2017; 6 DOI: 10.7554/eLife.25125" Complex functionally specified informational complexityDionisio
August 22, 2017
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"Gene variant activity is surprisingly variable between tissues" Did somebody say "surprisingly"? There they go again. When are they going to stop getting so easily surprised? :)Dionisio
August 21, 2017
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