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Link between single genes and diseases questioned

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From The Scientist:

Many patients with genetic variations linked to cardiac disorders do not exhibit any symptoms, raising concerns about the validity of incidental findings of genetic tests.

“Over the last decade, genome-wide association studies (GWAS) have identified hundreds of new genetic variations, largely single-nucleotide polymorphisms (SNPs) that might serve as biomarkers for many common conditions,” Maine physician William Gregory Feero, an associate editor at JAMA, wrote in an accompanying editorial. “In general, these account for little in the variance of disease, and the predictive value of such SNPs has been largely disappointing.” More.

See also: There’s a gene for that… or is there?

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