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So the “gay gene” was imaginary?

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File:DNA simple.svg

It empowered a movement but existed only in their heads? A huge study involving nearly half a million people suggests so.

The largest study to date on the genetic basis of sexuality has revealed five spots on the human genome that are linked to same-sex sexual behaviour — but none of the markers are reliable enough to predict someone’s sexuality.

The findings, which are published on 29 August in Science and based on the genomes of nearly 500,000 people, shore up the results of earlier, smaller studies and confirm the suspicions of many scientists: while sexual preferences have a genetic component, no single gene has a large effect on sexual behaviours

.Jonathan Lambert, “No ‘gay gene’: Massive study homes in on genetic basis of human sexuality” at Nature

This is probably not the result many were looking for or could even report straightforwardly:

The five genes each explained less than 1 percent of the variation in whether or not an individual reported participating in same-sex behaviors. When they included all sequences in the genome associated with same-sex sex, the researchers estimated that genes account for a maximum of 8–25 percent of the variation in the population’s behaviors, suggesting that much of what drives sexual activity is beyond genetics.

“Genetics is less than half of this story for sexual behavior but it’s still a very important contributing factor,” Ben Neale, a behavioral geneticist at the Broad Institute and a senior author on the study, said during the press conference. Still, the genetic associations he and his colleagues observed could not predict the likelihood that an individual would report having sex with partners of the same sex.

Emma Yasinski, “Giant Study Helps Clarify Role of Genes in Same-Sex Sex” at TheScientist

Some simply deny the obvious conclusion:

However, the finding that there’s no single gay gene does not mean that sexual orientation is not genetic or biological, and is therefore a lifestyle choice.

“This is wrong,” study co-author Brendan Zietsch, a geneticist at the University of Queensland in Australia, told Live Science. “We find that there are many, many genes that predispose one to same-sex sexual behavior. Each of them individually has a very small effect, but together they have a substantial effect.

“Another possible misinterpretation is to think that if same-sex preference is genetically influenced, it must therefore be totally genetically determined,” Zietsch added. “That is not true. Genetically identical individuals — twins — often have different sexual orientations. We know there are non-genetic influences as well, but we don’t understand these well, and our study does not say anything about them.”

Charles Q. Choi, “The ‘Gay Gene’ Is a Total Myth, Massive Study Concludes” at LiveScience

Identical twins having the same sexual orientation used to be the gold standard for claims about the gay gene so if the researchers are backing away from that, we can be sure that the case for genetic determinism about sexual orientation is in ruins, even if this researcher insists that that is the “wrong” interpretation.

Why are people so uncomfortable with the idea that they are not ruled by their genes?

Bet we haven’t heard the last of this.

See also: There’s a gene for that… or is there?

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Comments
mimus @ 7 see medical definition of gay geneET
August 30, 2019
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EDTA,
All of which would appear to vindicate those of us who never did accept the existence of a single gay gene…
Did anyone claim such a gene existed?Mimus
August 30, 2019
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ET @ 5, Yes, the jury is still out on the whole picture of sexual preference. But I think it's relatively safe now to predict that one-gene-one-characteristic is on the way out for lots of traits: https://uncommondescent.com/intelligent-design/do-all-genes-affect-every-complex-trait/EDTA
August 30, 2019
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You should never say never when it comes any alleged genetic component of human behavior, including sexual preference. Our brains are ruled by chemicals. So any chemical imbalance caused by genetic entropy would have an effect. The same goes for the way any specific brain develops- genes control and influence that. The science is still young and it is way too early to call it a day. Who knows what else will be uncovered along the way?ET
August 30, 2019
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The write-up at ars technica was a little more explicit, for whatever that's worth: https://arstechnica.com/science/2019/08/the-genetics-of-sexual-orientation-are-about-as-complex-as-sexual-orientation/ "Studies of twins have suggested that genetics can influence homosexual behavior, accounting for roughly 20% to 30% of its frequency. But attempts to find specific genes that mediate this influence have come up empty. Now, an absolutely enormous study has found a number of genetic sites linked to homosexual behavior. But collectively, they account for a tiny amount of the total genetic effect, and their influence is complicated: different in men and women, and different even across the spectrum of sexual attraction. By comparing this relatedness to who had same-sex partners, the researchers were able to estimate the total genetic contribution to this behavior: 32%. That suggests the rest is some combination of environmental and social influences. And collectively, the authors suggest that the genetic influences they could track via GWAS correlated with a maximum of 25% of homosexual behavior—that's lower than the 32% figure calculated by relatedness. So, it's possible that there are also some more complicated genetics yet to be sorted out. Not only is there no "gay gene," but males and females have genetic influences that only partly overlap." All of which would appear to vindicate those of us who never did accept the existence of a single gay gene...EDTA
August 30, 2019
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It empowered a movement ...
When did this happen? Perhaps some people have claimed this existence of a simple Mendelian gene for homosexuality was an important for gay rihts. But i've never heard this.
Some simply deny the obvious conclusion:
What do you think the obvious conclusion is? The quoted text is very straightforward and true. If you think there is not genetic contribution to homosexuality (or same-sex sexual behaviour in the case of this study) then you should maybe read the paper.Mimus
August 30, 2019
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Brother Brian:
Nobody is uncomfortable about that.
Except for those millions of determinists, of course.
It is about the interaction of our genes and our environment.
Too vague and wishy-washy to be part of science. But that is the extent of evolutionary biology.
We have known this for longer than I have been alive.
So there should be plenty of peer-review on it- nature vs nurture? The environment made me do it? Whatever excuse works, I guess...ET
August 30, 2019
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Why are people so uncomfortable with the idea that they are not ruled by their genes?
Nobody is uncomfortable about that. But nice strawman. The claim has largely been that sexual attraction develops very early. Their is obviously a genetic component, as sex implies, but what we are is not all about our genes. It is about the interaction of our genes and our environment. We have known this for longer than I have been alive.Brother Brian
August 30, 2019
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