Such a theory is a sort of religious quest that has united philosophers, theologians, and scientists, But is it possible? Marcelo Gleiser doesn’t think so:
As Gleiser puts it, “The very process of discovery leads to more unknowns.” And they may be smaller or larger. For example, in 1977, Carl Woese (1928–2012) almost accidentally discovered a Third Kingdom of life, the Archaea — which are neither bacteria nor more complex life forms (eukaryotes). The fifth and sixth [fundamentsal] forces may be out there too.
News, “Physicist: Science, by nature, can’t have a theory of everything” at Mind Matters News (December 6, 2021)
Science is not, at any time in the foreseeable future, going to be all tied down and delivered in a box.
You may also wish to read: Can quantum physics, neuroscience merge as quantum consciousness? Physicist Marcelo Gleiser looks at the pros and cons of current theories. The problem is, if we assume that “the mind is nothing more than the brain,” there may be nothing we can discover about how it works.
and
Does science disprove free will? A physicist says no. Michael Egnor: Marcelo Gleiser notes that the mind is not a solar system with strict deterministic laws. Apart from simple laws governing neurons, we have no clue what laws the mind follows, though it does show complex nonlinear dynamics.
Also: Astronomer: We can’t just assume countless Earths out there. He points out that the Principle of Mediocrity is based on faulty logical reasoning. Marcelo Gleiser notes that the starting point of the Mediocrity Principle assumes countless Earths. That’s not a conclusion from evidence. It’s bad logic.
Takehome: As Marcelo Gleiser puts it, “The very process of discovery leads to more unknowns.” And they may be smaller or larger than our current knowns.