Epigenetics Intelligent Design

At the Scientist: The epigenetic couch potato mouse debuts

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The obvious link is made to the relationship between exercise and obesity in childhood:

“If you look in textbooks about regulation of energy balance, they’ll talk about AgRP neurons and their classic role in regulating food intake,” says Waterland. “And yet we didn’t see that. We didn’t see that at all.”

So they tried again. This time, they knocked out the same gene the same way at the same point in development. They fed the mice the same diets. But now they gave the animals access to a running wheel for eight weeks. “That is where we saw the most profound difference,” says Waterland. “Compared to the wild type mice that run about six kilometers a night, these knockout mice only run about half that much.”

While all the mice lost some body fat after being given access to the wheels, the mice that ran more lost more than their more sedentary counterparts.


Emma Yasinski, “Early Epigenetic Changes Regulate Voluntary Exercise in Mice: Study” at The Scientist

The DNA methylations was changed so the mice might pass on laziness.

Textbooks? Textbooks run on Darwinism, not epigenetics, as anyone who has fought in the textbook wars knows.

Also:

Along with clarifying the mechanisms underlying the differences in activity levels, the obvious next step, according to Waterland, is to see what the results mean for humans. Much of the epigenetic regulation that occurs in the mouse hypothalamus is established during the so-called suckling period, the first 21 days after their birth. “And that’s the process we interfered with,” he says. But in humans, the timing may be different.

Emma Yasinski, “Early Epigenetic Changes Regulate Voluntary Exercise in Mice: Study” at The Scientist

Almost certainly, the timing is different so the critical question is, how wide is that window? Months? Years?

As Yasinki’s story goes on to discuss, it’s not about the capacity for exercise

but the motivation to exercise. Would humans be affected by different motivations?

Paper. (open access)

Why the sea is boiling hot: It’s not just that Darwinian evolution is not being demonstrated to any degree but that a lot of non-Darwinian evolution is being demonstrated.

See also: Irresistible! An epigenetic couch potato mouse Cats everywhere delighted

and

Epigenetic change: Lamarck, wake up, you’re wanted in the conference room!

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9 Replies to “At the Scientist: The epigenetic couch potato mouse debuts

  1. 1
    Mimus says:

    Hmm.. the study isn’t about evolution at all. But it does demonstrate this trait is the result of an interaction between a particular gene and an environmental stimulus. Not sure why this would be a problem for evolutionary biology?

  2. 2
    Reapers Plague says:

    Mimus

    Hmm.. the study isn’t about evolution at all. But it does demonstrate this trait is the result of an interaction between a particular gene and an environmental stimulus. Not sure why this would be a problem for evolutionary biology?

    I’ve never understood this either. We have long known that the phenotype is the result of the interaction of genetics and the environment. All that is happening is that we are gaining a much better understanding of how this works.

  3. 3
    ET says:

    We have long known that the phenotype is the result of the interaction of genetics and the environment

    Except for the fact that we don’t know that. No one knows what determines phenotype. See geneticist Giuseppe Sermonti’s “Why is a Fly Not a Horse?” and Denton’s “Nature’s Destiny”. Not even “Your Inner Fish”, “Making of the Fittest” or “Endless Forms…” support the claim that the phenotype is the result of the interaction of genetics and the environment. Evos need that to be the case but that has not been shown to be the case.

  4. 4
    Ed George says:

    Deleted by commenter.

  5. 5
    Ed George says:

    Reaper is correct. By altering DNA we can change the phenotype (that is why we can produce insulin using bacteria. Change the environment and we can change the phenotype. That is why the sex of a turtle is affected by incubation temperature. But without the genes necessary for the growth of testes or ovaries, neither is possible, regardless of the temperature.

  6. 6
    Reapers Plague says:

    Ed, and ET’s estrogen injections, interacting with his DNA, is why he has grown breasts. At least his wife is now happy that he leaves her alone.

    UD: Reaper is no longer with us.

  7. 7
    ET says:

    Acartia Eddie:

    By altering DNA we can change the phenotype (that is why we can produce insulin using bacteria).

    That is different from what was said. Altering a phenotype is not the same as determining the phenotype. The bacteria is still a bacteria. Same body plan just with an artificial gene. The turtles are still the same turtles- same body plan. They were going to be turtles regardless of the environment.

    We do not know what determines the phenotype, turtle vs bird, for example. Yes, we thought it was the genome, with the environment providing those slight changes. But with the advent of whole genome sequencing that has NOT panned out. See “Nature’s Destiny”…

  8. 8
    ET says:

    Great. Now Acartia Eddie George is back @ the swamp saying he was Reaper’s Plague…

  9. 9
    Silver Asiatic says:

    If so then that ID should be banned here also.

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