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Cells and proteins use sugars to talk to one another

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structure of an animal cell/royroydeb (CC BY-SA 4.0)

From ScienceDaily:

Research reveals how cells communicate at the molecular level. They found that sugar molecules play a key role in cellular communication, serving as the ‘channels’ that cells and proteins use to talk to one another. This work also provides researchers with a new tool to study other living systems in incredible detail, enabling future breakthroughs in fields from materials science to nanomedicine. Paper.(open access) – Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Möller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec. Encoding biological recognition in a bicomponent cell-membrane mimic. Proceedings of the National Academy of Sciences, 2019; 201821924 DOI: 10.1073/pnas.1821924116 More.

Cells are like Neanderthal man. They get smarter every time we run into them. And just think, it all just tumbled into existence by natural selection acting on random mutations (Darwinism) too…

Before you go: Researchers: First animal cell was not simple; it could “transdifferentiate” From the paper: “… these analyses offer no support for the homology of sponge choanocytes and choanoflagellates, nor for the view that the first multicellular animals were simple balls of cells with limited capacity to differentiate.”

“Interspecies communication” strategy between gut bacteria and mammalian hosts’ genes described

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Researcher: Mathematics Sheds Light On “Unfathomably Complex” Cellular Thinking

How do cells in the body know where they are supposed to be?

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How Do Cells Interpret The “Dizzying” Communications Pathways In Multicellular Life Forms?

and

Cell atlases reveal extreme complexity at biology’s frontiers

Comments
jawa, Yes, agree that gpuccio’s scientific contributions are greatly missed here.PeterA
March 9, 2019
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Missing GPuccio’s scientific OPs and comments lately.jawa
March 8, 2019
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“The observed sugar phase-separated hierarchical arrays with lamellar and hexagonal morphologies that encode biological recognition are among the most complex architectures yet discovered in soft matter. ” “This supramolecular patterning offers a fundamental mechanism for programming enhanced activity via the surface morphology of globular glycoconjugate assemblies, such as liposomes, polymersomes, and cell-like hybrids (44, 45). Indeed, this approach informs a general design and structural analysis principle for active complex soft matter (62, 63), which will enable technological applications ranging from materials science to nanomedicine (74).” Encoding biological recognition in a bicomponent cell-membrane mimic. Proceedings of the National Academy of Sciences, 2019; 201821924 DOI: 10.1073/pnas.1821924116PeterA
March 5, 2019
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designed dendritic macromolecules are shown to self-assemble into vesicles that function as biological-membrane mimics with controlled density of sugar moieties on their periphery. Surprisingly, lowering sugar density elicits higher bioactivity to sugar-binding proteins. This finding informs a design principle for active complex soft matter with potential for applications in cellular biology and nanomedicine.“ Encoding biological recognition in a bicomponent cell-membrane mimic. Proceedings of the National Academy of Sciences, 2019; 201821924 DOI: 10.1073/pnas.1821924116 Emphasis addedPeterA
March 5, 2019
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