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DNA machinery in maize accidentally governs hundreds of genes

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From Phys.org:

150,000 quadruplex DNA sequence motifs found to be ‘non-randomly’ distributed throughout the genetic material of maize:

Excerpt: A team led by Florida State University researchers has identified DNA elements in maize that could affect the expression of hundreds or thousands of genes.

“Maybe they are part of the machinery that allows an organism to turn hundreds of genes off or on,”

Bass and Carson Andorf… began this exploration of the maize genome sequence along with colleagues from FSU, Iowa State and the University of Florida. They wanted to know if certain DNA structures such as the four-strand G-quadruplex (G4) DNA might exist throughout the genetic material of maize.
G4 structures are present in genes that regulate cancer and cell division in humans, making it an important focus in scientific research. But, not much is known about them.

The general public thinks of DNA as two connected strands known as the double helix. But scientists also discovered over the years that those strands regularly separate so they can replicate the genetic material. That material can also twist into different shapes such as a G-quadruplex.

Bass and his colleagues found 150,000 sequence motifs that could theoretically adopt the G4 DNA structure, and they were distributed all over the chromosomes. Further examination showed that they were present in very specific places, as opposed to a random distribution.More.

Jus’ an accident, right? Here’s Evolution News & Views’s view.

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Hat tip: Philip Cunningham

2 Replies to “DNA machinery in maize accidentally governs hundreds of genes

  1. 1
    Silver Asiatic says:

    Evolution News & Views’s view.

    I wondered how it evolved also – they made it so easy to understand:

    For instance, Mirkin says, “The Pif1 helicase family of enzymes has evolved to disentangle these structures efficiently.” Evolution even evolved all the cell’s DNA machines: “Because formation of unusual DNA structures is a recurrent problem, cells have evolved defensive mechanisms to deal with them.”

    Evolution is so wonderful. Something was needed to disentangle the structures so a family of enzymes evolved to do the job. Plus, evolution had to deal with “unusual DNA structures” and we all know what a problem those could be. But evolution figured out a way to “deal with them”. Good job, evolution! I’m so proud of you.

    “Thus, unraveling G-quadruplexes seems to be a conserved function of Pif1 helicases that arose very early in evolution.”

    Ahh – got it. I was wondering how this happened. It “arose”. Plus, evolution made sure it happened “very early” and then conserved it because it’s such a great thing to have.

    Evolution knew that if it didn’t do something about all that entanglement, we would have lots of extinctions — so it “arose” something to “deal with” these issues.

    I learn so much from evolution. Whenever you have a problem, make something arise to solve it. Then, conserve that solution as a defense mechanism.

    That way, you’ll be a lot happier and problem-free, just the way evolution wants us to be!

  2. 2
    bornagain77 says:

    Silver Asiatic

    ABC News Says “‘Darwin’s Dilemma’ May Be Solved”: What, Again?
    Casey Luskin December 3, 2014
    http://www.evolutionnews.org/2.....91661.html

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