Flagellum vid passes 50k views

_{Denyse O'Leary

May 5, 2019

Intelligent Design, Irreducible Complexity}

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A few more notes on the flagellum: Biologist Howard Berg at Harvard has called the Bacterial Flagellum
“the most efficient machine in the universe.” - Howard Berg
A few more notes:
Electron Microscope Photograph of Flagellum Hook-Basal Body http://www.skeptic.com/eskeptic/08-08-20images/figure03.jpg Bacterial Flagellum: Visualizing the Complete Machine In Situ Excerpt: Electron tomography of frozen-hydrated bacteria, combined with single particle averaging, has produced stunning images of the intact bacterial flagellum, revealing features of the rotor, stator and export apparatus. http://www.sciencedirect.com/science/article/pii/S096098220602286X The Flagellar Filament Cap: Up close micro-photograph and animations of cap – Jonathan M. – August 2013 Excerpt: We are so used to thinking about biological machines at a macroscopic level that it is all too easy to overlook the molecular structure of their individual components. The closer we inspect biochemical systems, such as flagella, the more the elegant design — as well as the magnitude of the challenge to Darwinism — becomes apparent. http://www.evolutionnews.org/2013/08/the_flagellar_f075101.html Structural diversity of bacterial flagellar motors – 2011 Excerpt: Figure 3 – Manual segmentation of conserved (solid colours) and unconserved (dotted lines) motor components based on visual inspection. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160247/figure/f3/ Incredible images reveal bacteria motor parts in unprecedented detail March 15, 2016 Excerpt: In flagellar motors, the turning force is produced by a ring of structures called stators around the motor. The team found that Campylobacter jejuni had almost twice as many stators positioned around the motor than in Salmonella, and that these structures sat in a wider ring. More stators provide increased torque, and the increased width of the ring means individual stators exert more leverage when rotating the helical propeller. http://www.pnas.org/content/early/2016/03/09/1518952113/F1.expansion.html Flagellar Diversity Challenges Darwinian Evolution, Not Intelligent Design – Casey Luskin – July 22, 2015 Excerpt: flagella are distributed in a polyphyletic manner that doesn’t fit what we’d expect from common ancestry,,, http://www.evolutionnews.org/2015/07/flagellar_diver097831.html The Bacterial Flagellum: A Paradigm for Design – Jonathan M. – Sept. 2012 Excerpt: Indeed, so striking is the appearance of intelligent design that researchers have modeled the assembly process (of the bacterial flagellum) in view of finding inspiration for enhancing industrial operations (McAuley et al.). Not only does the flagellum manifestly exhibit engineering principles, but the engineering involved is far superior to humanity’s best achievements. The flagellum exhibits irreducible complexity in spades. In all of our experience of cause-and-effect, we know that phenomena of this kind are uniformly associated with only one type of cause – one category of explanation – and that is intelligent mind. Intelligent design succeeds at precisely the point at which evolutionary explanations break down. http://www.scribd.com/doc/106728402/The-Bacterial-Flagellum Two Flagella Are Better than One – September 3, 2014 Excerpt: The assembly instructions,, are even more irreducibly complex than the motor itself. Parts are arriving on time and moving into place in a programmed sequence, with feedback to the nucleus affecting how many parts are to be manufactured. Dr. Jonathan Wells added, “What we see is irreducible complexity all the way down.” Twelve years of closer looks at these astonishing machines have only amplified those conclusions. http://www.evolutionnews.org/2014/09/two_flagella_ar089611.html Souped-Up Hyper-Drive Flagellum Discovered – December 3, 2012 Excerpt: Get a load of this — a bacterium that packs a gear-driven, seven-engine, magnetic-guided flagellar bundle that gets 0 to 300 micrometers in one second, ten times faster than E. coli. If you thought the standard bacterial flagellum made the case for intelligent design, wait till you hear the specs on MO-1,,, Harvard’s mastermind of flagellum reverse engineering, this paper describes the Ferrari of flagella. “Instead of being a simple helically wound propeller driven by a rotary motor, it is a complex organelle consisting of 7 flagella and 24 fibrils that form a tight bundle enveloped by a glycoprotein sheath…. the flagella of MO-1 must rotate individually, and yet the entire bundle functions as a unit to comprise a motility organelle.” To feel the Wow! factor, jump ahead to Figure 6 in the paper. It shows seven engines in one, arranged in a hexagonal array, stylized by the authors in a cross-sectional model that shows them all as gears interacting with 24 smaller gears between them. The flagella rotate one way, and the smaller gears rotate the opposite way to maximize torque while minimizing friction. Download the movie from the Supplemental Information page to see the gears in action. http://www.evolutionnews.org/2012/12/souped-up_flage066921.html
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Of supplemental note: Here are a few more falsifications of Darwinian evolution that Darwinists simply refuse to accept as falsifications of their theory:
Darwin’s theory holds mutations to the genome to be random. The vast majority of mutations to the genome are not random but are found to be ‘directed’. Darwin’s theory holds that Natural Selection is the ‘designer substitute’ that produces the ‘appearance’ and/or illusion of design. Natural Selection, especially for multicellular organisms, is found to grossly inadequate as the ‘designer substitute. Darwin’s theory holds that mutations to DNA will eventually change the basic biological form of any given species into a new form of a brand new species. Yet, biological form is found to be irreducible to mutations to DNA, nor is biological form reducible to any other material particulars in biology one may wish to invoke. Darwin’s theory holds there to be an extremely beneficial and flexible mutation rate for DNA which was ultimately responsible for all the diversity and complexity of life we see on earth. The mutation rate to DNA is overwhelmingly detrimental. Detrimental to such a point that it is seriously questioned whether there are any truly beneficial, information building, mutations whatsoever. Charles Darwin himself held that the gradual unfolding of life would (someday) be self-evident in the fossil record. Yet, from the Cambrian Explosion onward, the fossil record is consistently characterized by sudden appearance of a group/kind in the fossil record(disparity), then rapid diversity within that group/kind, and then long term stability and even deterioration of variety within the overall group/kind, and within the specific species of the kind, over long periods of time. Of the few dozen or so fossils claimed as transitional, not one is uncontested as a true example of transition between major animal forms out of millions of collected fossils. Moreover, Fossils are found in the “wrong place” all the time (either too early, or too late). Darwin’s theory, due to the randomness postulate, holds that patterns will not repeat themselves in supposedly widely divergent species. Yet thousands of instances of what is ironically called ‘convergent evolution’, on both the morphological and genetic level, falsifies the Darwinian belief that patterns will not repeat themselves in widely divergent species. Charles Darwin himself stated that “If it could be demonstrated that any complex organ existed which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down.” Yet as Doug Axe pointed out, “Basically every gene and every new protein fold, there is nothing of significance that we can show that can be had in that gradualistic way. It’s all a mirage. None of it happens that way.” Charles Darwin himself stated that “If it could be proved that any part of the structure of any one species had been formed for the exclusive good of another species, it would annihilate my theory, for such could not have been produced through natural selection.” Yet as Wolf-Ekkehard Lönnig pointed out, “in thousands of plant species often entirely new organs have been formed for the exclusive good of more than 132,930 other species, these ‘ugly facts’ have annihilated Darwin’s theory as well as the modern versions of it.” Charles Darwin himself stated that, ““The impossibility of conceiving that this grand and wondrous universe, with our conscious selves, arose through chance, seems to me the chief argument for the existence of God.”. Yet ‘our conscious selves’ are certainly not explainable by ‘chance’ (nor is consciousness explainable by any possible reductive materialistic explanation in general), i.e. ‘the hard problem of consciousness’. Besides the mathematics of probability consistently showing that Darwinian evolution is impossible, the mathematics of population genetics itself has now shown Darwinian evolution to be impossible. Moreover, ‘immaterial’ mathematics itself, which undergirds all of science, engineering and technology, is held by most mathematicians to exist in some timeless, unchanging, immaterial, Platonic realm. Yet, the reductive materialism that Darwinian theory is based upon denies the existence of the immaterial realm that mathematics exists in. i.e. Darwinian evolution actually denies the objective reality of the one thing, i.e. mathematics, that it most needs in order to be considered scientific in the first place! Donald Hoffman has, via population genetics, shown that if Darwin’s materialistic theory were true then all our observations of reality would be illusory. Yet the scientific method itself is based on reliable observation. Moreover, Quantum Mechanics itself has now shown that conscious observation must come before material reality, i.e. falsification of ‘realism’ proves that our conscious observations are reliable!. The reductive materialism that undergirds Darwinian thought holds that immaterial information is merely ’emergent’ from a material basis. Yet immaterial Information, via experimental realization of the “Maxwell’s Demon” thought experiment, is now found to be its own distinctive physical entity that, although it can interact in a ‘top down’ manner with matter and energy, is separate from matter and energy. Darwinists hold that Darwin’s theory is true. Yet ‘Truth’ itself is an abstract property of an immaterial mind that is irreducible to the reductive materialistic explanations of Darwinian evolution. i.e. Assuming reductive materialism and/or Naturalism as the starting philosophical position of science actually precludes ‘the truth’ from ever being reached by science! Darwinist’s, due to their underlying naturalistic philosophy, insist that teleology (i.e. goal directed purpose) does not exist. Yet it is impossible for Biologists to do biological research without constantly invoking words that directly imply teleology. i.e. The very words that Biologists themselves use when they are doing their research falsifies Darwinian evolution.
On top of all that, all of science, every nook and cranny of it, is based on intelligent design and is certainly not based on methodological naturalism as is presupposed by Darwinists. From the essential Christian presuppositions that undergird the founding of modern science, i.e. that the universe is rational and that the minds of men, being made in the ‘image of God’, can dare understand that rationality, to the intelligent design of the scientific instruments and experiments themselves, to the logical and mathematical analysis of experimental results, from top to bottom science itself is certainly not ‘natural’. Not one scientific instrument would ever exist if men did not first intelligently design that scientific instrument. Not one test tube, microscope, telescope, spectroscope, or etc.. etc.., was ever just found laying around on a beach somewhere which was ‘naturally’ constructed by nature. Not one experimental result would ever be rationally analysed since there would be no immaterial minds to rationally analyze the immaterial mathematics that lay behind the intelligently designed experiments in the first place. In fact, (as I have pointed out several times now), assuming (Methodological) Naturalism instead of Theism as the worldview on which all of science is based leads to the catastrophic epistemological failure of science itself.
Basically, because of reductive materialism (and/or methodological naturalism), the atheistic materialist is forced to claim that he is merely a ‘neuronal illusion’ (Coyne, Dennett, etc..), who has the illusion of free will (Harris), who has unreliable beliefs about reality (Plantinga), who has illusory perceptions of reality (Hoffman), who, since he has no real time empirical evidence substantiating his grandiose claims, must make up illusory “just so stories” with the illusory, and impotent, ‘designer substitute’ of natural selection (Behe, Gould, Sternberg), so as to ‘explain away’ the appearance (i.e. illusion) of design (Crick, Dawkins), and who must make up illusory meanings and purposes for his life since the reality of the nihilism inherent in his atheistic worldview is too much for him to bear (Weikart), and who must also hold morality to be subjective and illusory since he has rejected God (Craig, Kreeft). Bottom line, nothing is real in the atheist’s worldview, least of all, morality, meaning and purposes for life.,,, – Darwin’s Theory vs Falsification – 39:45 minute mark https://youtu.be/8rzw0JkuKuQ?t=2387
Thus, although the Darwinist may firmly believes he is on the terra firma of science (in his appeal, even demand, for methodological naturalism), the fact of the matter is that, when examining the details of his materialistic/naturalistic worldview, it is found that Darwinists/Atheists are adrift in an ocean of fantasy and imagination with no discernible anchor for reality to grab on to. It would be hard to fathom a worldview more antagonistic to modern science than Atheistic materialism and/or methodological naturalism have turned out to be.
2 Corinthians 10:5 Casting down imaginations, and every high thing that exalteth itself against the knowledge of God, and bringing into captivity every thought to the obedience of Christ;
Bottom line, by any reasonable measure by which someone may wish to judge whether a proposition is even scientific or not, Darwinian evolution fails to qualify as a science:
“There are five standard tests for a scientific hypothesis. Has anyone observed the phenomenon — in this case, Evolution — as it occurred and recorded it? Could other scientists replicate it? Could any of them come up with a set of facts that, if true, would contradict the theory (Karl Popper’s “falsifiability” tests)? Could scientists make predictions based on it? Did it illuminate hitherto unknown or baffling areas of science? In the case of Evolution… well… no… no… no… no… and no.” – Tom Wolfe – The Kingdom of Speech – page 17 Darwinian Evolution Fails the Five Standard Tests of a Scientific Hypothesis – video https://www.youtube.com/watch?v=L7f_fyoPybw
In short, Darwinian evolution, since it fails to even qualify as a science in any meaningful sense, is much more realistically classified as a pseudoscientific religion for atheists. Darwinists, (and I have no doubt that many of them are sincere in their belief that Darwinism is truly ‘scientific’), are simply profoundly deceived in their belief that Darwinian evolution even qualifies as a science in the first place. Verse:
1 Thessalonians 5:21 but test everything; hold fast what is good.
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Moreover, even these ‘realistic’ estimates for finding functional proteins are far too optimistic. As Kurt Durston explains in the following article, “interdependence” among amino acid sites in proteins greatly reduce the number of possible functional protein sequences by many orders of magnitude.
(A Reply To PZ Myers) Estimating the Probability of Functional Biological Proteins? Kirk Durston , Ph.D. Biophysics – 2012 Excerpt (Page 4): The Probabilities Get Worse This measure of functional information (for the RecA protein) is good as a first pass estimate, but the situation is actually far worse for an evolutionary search. In the method described above and as noted in our paper, each site in an amino acid protein sequence is assumed to be independent of all other sites in the sequence. In reality, we know that this is not the case. There are numerous sites in the sequence that are mutually interdependent with other sites somewhere else in the sequence. A more recent paper shows how these interdependencies can be located within multiple sequence alignments.[6] These interdependencies greatly reduce the number of possible functional protein sequences by many orders of magnitude which, in turn, reduce the probabilities by many orders of magnitude as well. In other words, the numbers we obtained for RecA above are exceedingly generous; the actual situation is far worse for an evolutionary search. http://powertochange.com/wp-content/uploads/2012/11/Devious-Distortions-Durston-or-Myers_.pdf
And amino acids in proteins are now found to be extremely interdependent within proteins:
Proteins with cruise control provide new perspective: “A mathematical analysis of the experiments showed that the proteins themselves acted to correct any imbalance imposed on them through artificial mutations and restored the chain to working order.” http://www.princeton.edu/main/news/archive/S22/60/95O56/
The reason why the amino acids are extremely interdependent in a protein is because proteins are now found to operate on quantum principles, As the following paper explains, proteins “remain entangled as a single quantum state”
Coherent Intrachain energy migration at room temperature – Elisabetta Collini & Gregory Scholes – University of Toronto – Science, 323, (2009), pp. 369-73 Excerpt: The authors conducted an experiment to observe quantum coherence dynamics in relation to energy transfer. The experiment, conducted at room temperature, examined chain conformations, such as those found in the proteins of living cells. Neighbouring molecules along the backbone of a protein chain were seen to have coherent energy transfer. Where this happens quantum decoherence (the underlying tendency to loss of coherence due to interaction with the environment) is able to be resisted, and the evolution of the system remains entangled as a single quantum state. http://www.scimednet.org/quantum-coherence-living-cells-and-protein/
How many orders of magnitude does this interdependence of amino acids within a protein add to the already astronomical estimate for finding a functional protein? Well the following paper states that “finding even one that is in the quantum critical state by accident is mind-bogglingly small and, to all intents and purposes, impossible.,, of the order of 10^-50 of possible small biomolecules and even less for proteins,”,,,
Quantum criticality in a wide range of important biomolecules Excerpt: “Most of the molecules taking part actively in biochemical processes are tuned exactly to the transition point and are critical conductors,” they say. That’s a discovery that is as important as it is unexpected. “These findings suggest an entirely new and universal mechanism of conductance in biology very different from the one used in electrical circuits.” The permutations of possible energy levels of biomolecules is huge so the possibility of finding even one that is in the quantum critical state by accident is mind-bogglingly small and, to all intents and purposes, impossible.,, of the order of 10^-50 of possible small biomolecules and even less for proteins,”,,, “what exactly is the advantage that criticality confers?” https://medium.com/the-physics-arxiv-blog/the-origin-of-life-and-the-hidden-role-of-quantum-criticality-ca4707924552
Moreover, as if all that was not bad enough for Darwinists, quantum entanglement is a ‘non-local’, beyond space and time, effect that requires a cause that is not limited to space and time.
Looking beyond space and time to cope with quantum theory – 29 October 2012 Excerpt: “Our result gives weight to the idea that quantum correlations somehow arise from outside spacetime, in the sense that no story in space and time can describe them,” http://www.quantumlah.org/highlight/121029_hidden_influences.php
I’m pretty sure that Darwinists do not want to ever go down the route of looking for a ‘beyond space and time’ cause! It pretty much defeats their entire reductive materialistic and/or Atheistic worldview right off the bat!
Colossians 1:17 He is before all things, and in Him all things hold together.
In regards to how his work, and the work of others. falsify Charles Darwin's claim, in the following video Dr. Axe states: "Charles Darwin said (paraphrase) "If anyone could find anything that could not be had through a number of slight, successive, modifications my theory would absolutely breakdown." Well, that condition has been met time and time again now. Basically every gene and every new protein fold, there is nothing of significance that we can show that can be had in that gradualistic way. It's all a mirage. None of it happens that way."
"Charles Darwin said (paraphrase) "If anyone could find anything that could not be had through a number of slight, successive, modifications my theory would absolutely breakdown." Well, that condition has been met time and time again now. Basically every gene and every new protein fold, there is nothing of significance that we can show that can be had in that gradualistic way. It's all a mirage. None of it happens that way." - Douglas Axe - 200 Years After Darwin - What Didn't Darwin Know? - (5:30 minute mark) video - Part 2 of 2 https://youtu.be/VKIgNroTj54?t=329
Thus, even though Charles Darwin had disingenuously placed an exceeding high empirical burden on the opponents of his theory to prove that his theory was completely impossible, nonetheless, as far as empirical science itself is concerned, Darwinian evolution has now been empirically falsified time and time again as being astronomically impossible. Moreover, when considering recent advances in Quantum Biology, it is now found that the reductive materialistic foundation that Darwinian evolution is based upon is a completely incorrect theoretical foundation for molecular biology to be based upon in the first place.
Darwinian Materialism vs Quantum Biology - video https://www.youtube.com/watch?v=LHdD2Am1g5Y
In fact, the bacterial flagellum itself belongs to the world of quantum biology and is therefore impossible for the reductive materialistic framework of Darwinian evolution to explain the origin of:
INFORMATION AND ENERGETICS OF QUANTUM FLAGELLA MOTOR Hiroyuki Matsuura, Nobuo Noda, Kazuharu Koide Tetsuya Nemoto and Yasumi Ito Excerpt from bottom page 7: Note that the physical principle of flagella motor does not belong to classical mechanics, but to quantum mechanics. When we can consider applying quantum physics to flagella motor, we can find out the shift of energetic state and coherent state. http://www2.ktokai-u.ac.jp/~shi/el08-046.pdf
Thus, not only is Darwinian evolution empirically shown to be impossible, but Darwinian evolution is also now shown, with its reductive materialistic foundation, to not even be in the correct 'theoretical ballpark' to begin with. To put it mildly, as far as science itself is concerned, that is just plain embarrassing for Darwinists:bornagain77_{May 6, 2019
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A little background information. Dr. Michael Behe cut his teeth on the bacterial flagellum. When he first saw the bacterial flagellum, he stated,
"I remember the first time I looked in a biochemistry textbook and I saw a drawing of something called a bacterial flagellum, with all of its parts in all of its glory. It had a propeller. It had a hook region and the drive shaft and the motor. So I looked at that and said, "That's an outboard motor. That's designed. That's no chance assemblage of parts." Michael Behe - Irreducible Complexity - video - 15:43 minute mark https://youtu.be/VekUf325SHM?t=943
As you can see from the preceding video, the argument that Dr. Behe put forth against the notion that the gradual processes Darwinian evolution could possibly construct such a elegant machine was what is termed "Irreducible Complexity".
"Irreducible complexity is just a fancy phrase I use to mean a single system which is composed of several interacting parts, and where the removal of any one of the parts causes the system to cease functioning." (Behe, 1996, speech delivered to the Discovery Institute)
Along that line, Charles Darwin himself stated that
"If it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down." (Darwin, Origin of Species, 1st edn, p 189)
Please note in the preceding passage that Charles Darwin, for his theory to be considered valid, did not require that his mechanism of Random Variation and Natural Selection actually be empirically demonstrated to be plausible in the first place (as other scientific theories commonly do), but he disingenuously put the empirical burden on the opponents of his theory to prove that his mechanism was completely impossible. And although that empirical burden that Darwin set forth , (besides being disingenuous to the primary issue of if his mechanism is even plausible in the first place), was, and is, exceeding high, nonetheless that exceedingly high empirical burden that Darwin set forth for his opponents to meet has now been met time and again. In his book "The Edge of Evolution", Dr. Behe estimated, from observational evidence, that the limit for what Darwinian evolution could be expected to accomplish, in terms of building up functional complexity, was an event with the probability of happening of 1 in 10^20.
"the likelihood of developing two binding sites in a protein complex would be the square of the probability for getting one: a double CCC, 10^20 times 10^20, which is 10^40. There have likely been fewer than 10^40 cells in the world in the last 4 billion years, so the odds are against a single event of this variety in the history of life. It is biologically unreasonable.” – Michael Behe – The Edge of Evolution – page 146 "The number I cite, one parasite in every 10^20 for de novo chloroquine resistance, is not a probability calculation. Rather, it is a statistic, a result, a data point. (Furthermore, it is not my number, but that of the eminent malariologist Nicholas White.) I do not assume that “adaptation cannot occur one mutation at a time”; I assume nothing at all. I am simply looking at the results. The malaria parasite was free to do whatever it could in nature; to evolve resistance, or outcompete its fellow parasites, by whatever evolutionary pathway was available in the wild. Neither I nor anyone else were manipulating the results. What we see when we look at chloroquine-resistant malaria is pristine data — it is the best that random mutation plus selection was able to accomplish in the wild in 10^20 tries." - Michael Behe https://evolutionnews.org/2007/11/rebuttal_to_paul_gross_review/ Waiting Longer for Two Mutations - Michael J. Behe Excerpt: Citing malaria literature sources (White 2004) I had noted that the de novo appearance of chloroquine resistance in Plasmodium falciparum was an event of probability of 1 in 10^20. I then wrote that 'for humans to achieve a mutation like this by chance, we would have to wait 100 million times 10 million years' (1 quadrillion years)(Behe 2007) (because that is the extrapolated time that it would take to produce 10^20 humans). Durrett and Schmidt (2008, p. 1507) retort that my number ‘is 5 million times larger than the calculation we have just given’ using their model (which nonetheless "using their model" gives a prohibitively long waiting time of 216 million years). Their criticism compares apples to oranges. My figure of 10^20 is an empirical statistic from the literature; it is not, as their calculation is, a theoretical estimate from a population genetics model. Generally, when the results of a simple model disagree with observational data, it is an indication that the model is inadequate.,,, The difficulty with models such as Durrett and Schmidt’s is that their biological relevance is often uncertain, and unknown factors that are quite important to cellular evolution may be unintentionally left out of the model. That is why experimental or observational data on the evolution of microbes such as P. falciparum are invaluable,,, http://www.discovery.org/a/9461
Moreover, in 2014 Dr. Behe's 1 in 10^20 statistical observation has now been born out empirically.
Guide of the Perplexed: A Quick Reprise of The Edge of Evolution - Michael Behe - August 20, 2014 Excerpt: In The Edge of Evolution I cited the development of chloroquine resistance in the malaria parasite Plasmodium falciparum as a very likely real-life example of this phenomenon. The recent paper by Summers et al. confirms that two specific mutations are required to confer upon the protein PfCRT the ability to pump chloroquine, which is necessary but may not be sufficient for resistance in the wild. *Any particular adaptive biochemical feature requiring the same mutational complexity as that needed for chloroquine resistance in malaria is forbiddingly unlikely to have arisen by Darwinian processes and fixed in the population of any class of large animals (such as, say, mammals), because of the much lower population sizes and longer generation times compared to that of malaria. (By "the same mutational complexity" I mean requiring 2-3 point mutations where at least one step consists of intermediates that are deleterious, plus a modest selection coefficient of, say, 1 in 10^3 to 1 in10^4. Those factors will get you in the neighborhood of 1 in 10^20.) *Any adaptive biological feature requiring a mutational pathway of twice that complexity (that is, 4-6 mutations with the intermediate steps being deleterious) is unlikely to have arisen by Darwinian processes during the history of life on Earth.,,, What's more, Nicholas White's factor of 1 in 10^20 already has built into it all the ways to evolve chloroquine resistance in P. falciparum. In the many malarial cells exposed to chloroquine there have surely occurred all possible single mutations and probably all possible double mutations -- in every malarial gene -- yet only a few mutational combinations in pfcrt are effective. In other words, mutation and selection have already searched all possible solutions of the entire genome whose probability is greater than 1 in 10^20, including mutations to other genes. The observational evidence demonstrates that only a handful are effective. There is no justification for arbitrarily inflating probabilistic resources by citing imaginary alternative evolutionary routes. http://www.evolutionnews.org/2014/08/guide_of_the_pe089161.html How Many Ways Are There to Win at Sandwalk? - Michael Behe - August 15, 2014 Excerpt: ,, with chloroquine resistance in Plasmodium falciparum. The best current statistical estimate of the frequency of de novo resistance is Nicholas White's value of 1 in 10^20 parasites. That number is now essentially fixed -- no pathway to resistance will be found that is substantially more probable than that. Although with more data the value may be refined up or down by even as much as one or two orders of magnitude (to between 1 in 10^18-10^22), it's not going very far on a log scale. Not nearly far enough to lift the shadow from Darwinism. What's more, we can also conclude that the mutations that have already been found are the most effective available of any combination of mutations whose joint probability is greater than 1 in 10^20, since more effective alternatives would already have occurred and been selected if they were available.,,, The bottom line for all of them is that the acquisition of chloroquine resistance is an event of statistical probability 1 in 10^20.,,, http://www.evolutionnews.org/2014/08/how_many_ways_a088981.html
In regards to this empirical validation of Dr, Behe’s estimate, in the following video Dr. Behe comments, “This is not an argument anymore that Darwinism cannot make complex functional systems; it is an observation that it does not.”
Michael Behe – Observed (1 in 10^20) Limits of Evolution – video – Lecture delivered in April 2015 at Colorado School of Mines 25:56 minute quote – “This is not an argument anymore that Darwinism cannot make complex functional systems; it is an observation that it does not.” 27:50 minute mark: no known, or unknown, evolutionary process helped. https://www.youtube.com/watch?v=9svV8wNUqvA
As well, Douglas Axe, as this following reference makes clear, has also done work falsifying Charles Darwin's claim that all of life can be explained by reference to “numerous, successive, slight modifications”. Specifically, Dr. Axe found that “the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences.”
Estimating the prevalence of protein sequences adopting functional enzyme folds - Doug Axe - 2004 Excerpt: The prevalence of low-level function in four such experiments indicates that roughly one in 10^64 signature-consistent sequences forms a working domain. Combined with the estimated prevalence of plausible hydropathic patterns (for any fold) and of relevant folds for particular functions, this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. https://www.ncbi.nlm.nih.gov/pubmed/15321723
Dr. Axe's work falls in line with other lines of research verifying the fact that functional proteins are extremely rare. As the following references make clear, all ‘realistic’ estimates for finding functional proteins are astronomically high:
Dan S. Tawfik Group - The New View of Proteins - Tyler Hampton - 2016 Excerpt: these odds are impossible.,,, Tawfik soberly recognizes the problem. The appearance of early protein families, he has remarked, is “something like close to a miracle.”45,,, “In fact, to our knowledge,” Tawfik and Tóth-Petróczy write, “no macromutations ... that gave birth to novel proteins have yet been identified.”69 The emerging picture, once luminous, has settled to gray. It is not clear how natural selection can operate in the origin of folds or active site architecture (of proteins). It is equally unclear how either micromutations or macromutations could repeatedly and reliably lead to large evolutionary transitions. What remains is a deep, tantalizing, perhaps immovable mystery. http://inference-review.com/article/the-new-view-of-proteins Yockey and a Calculator Versus Evolutionists – Cornelius Hunter PhD – September 25, 2015 Excerpt: In a 1977 paper published in the Journal of Theoretical Biology, Hubert Yockey used information theory to evaluate the likelihood of the evolution of a relatively simple protein.,,, Yockey found that the probability of evolution finding the cytochrome c protein sequence is about one in 10^64. That is a one followed by 64 zeros—an astronomically large number. He concluded in the peer-reviewed paper that the belief that proteins appeared spontaneously “is based on faith.” Indeed, Yockey’s early findings are in line with, though a bit more conservative than, later findings. A 1990 study of a small, simple protein found that 10^63 attempts would be required for evolution to find the protein. A 2004 study found that 10^64 to 10^77 attempts are required, and a 2006 study concluded that 10^70 attempts would be required. These requirements dwarf the resources evolution has at its disposal. Even evolutionists have had to admit that evolution could only have a maximum of 10^43 such experiments. It is important to understand how tiny this number is compared to 10^70. 10^43 is not more than half of 10^70. It is not even close to half. 10^43 is an astronomically tiny sliver of 10^70. Furthermore, the estimate of 10^43 is, itself, entirely unrealistic. For instance, it assumes the entire history of the Earth is available, rather than the limited time window that evolution actually would have had.,,, - per Darwin's God blog Dr. Durston elaborates on how futile an evolutionary search is to find a single functional protein: Excerpt: From this, we can come up with a very rough estimate for the total number of stable, folding 3D sequences in 300 residue sequence space … roughly 10^74 sequences that will give stable 3D folds (this is very rough, but it will illustrate my point and help one see why scientists don’t search for novel stable 3D folds from a library of random sequences). One might think that 10^75 sequences is an enormous number, however, it is miniscule in comparison with 20^300, which is the total number of sequences in 300 –residue sequence space. This is why the theory that an evolutionary search, even if it involved all the planets in all the galaxies of the known universe, is utterly implausible. https://uncommondescent.com/biophysics/kirk-durston-a-common-either-or-mistake-both-darwinists-and-id-theorists-make/#comment-466489
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