Uncommon Descent Serving The Intelligent Design Community

How the cell deals with supercoiled DNA during replication and transcription.

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I get angry when I hear the materialists always claim that those with an alternative view (maybe the correct one)need to prove their claims and then just reject the evidence because it doesn't suite their world view. Worse of all they feel justified when they can conceive a pathway (design?!) to achieve their desired outcome. No hard facts, just so stories. I'm sure were will hear many theories, but I doubt we will see any real experimental evidence to support how these "solutions" came about. vpr
Here is a good description of the type II topoisomerase. "The topoisomerase is thought to be a highly dynamic structure, with several gates for entry of DNA into the two DNA-sized holes. Two tyrosine amino acids, shown in red, cleave the DNA strands and form a covalent bond with them, holding them tightly until the DNA can be restored." http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_2.html Jehu
"Type II topoisomerase cuts both strands, and passes an unbroken double strand through it then reanneals the cut strand." It is amazing to me that singe enzyme has that much functionality. It looks like a little machinge. Apparently it is comprised of just two proteins. At two proteins, that is a lot bang for you buck. It cuts, passes through the unbroken strand, and then puts it back together. I would venture to guess that the chance mutation of this function is outside the universal probability bound. Jehu
These videos are simply amazing - freaky - but amazing. These processes seem so complex, so sophisticated, I can't believe life keeps working as well as it does. Information all stored and processed through chemistry. I really loved the RM+NS evolved proton motor. The blind watchmaker must have worked overtime on that one. This is just so far beyond any technology we have it makes us look like little kids playing with lincoln logs. shaner74
This was a pretty cool animation though wasn't it? Who would have thunk there was even a problem like this that had be solved and HTF did chance and necessity pull off cobbling together a solution. This one gets a 10 on my Weird-She-Tometer. DaveScot
Comparing evolutionary biologists to Microsoft management is hitting below the belt. I think you owe Microsoft an apology. DaveScot
Gil -- I think that even the Darwinists recognize this. However, they just can't admit it publicly without having a HUGE uproar about it. I think they are just keeping the lid on the problems until they come up with solutions for them. It's the same tactic Microsoft pulled. When NT4 was their flagship software, they called all negative comments about NT4 as the product of zealots speaking nonsense. As soon as Win2K came out, all of a sudden they were all-too-happy to discuss the problems of NT4 with you -- because that meant you would upgrade. All-of-a-sudden the problems with NT4 went from "this isn't true -- just a bunch of lies told by people who hate us" to "well of course NT4 was riddled with problems -- everyone knows that!" I see the same thing happening with Darwinism. Behe wasn't the first person to notice this. He was simply the first person in the field to both recognize it, speak publicly about it, and speak publicly about its obvious implications. johnnyb
The case is closed on the explanatory power of Darwinian mechanisms for processes and systems such as these. No more time or effort should be wasted trying to prop up such obviously deficient and silly ideas. Most practicing scientists recognize this, which is why Darwinists are moaning and groaning about the insufficient supply of references to their precious "theory" in the scientific literature. GilDodgen
Oh man, I just think of all those poor replicators that existed prior to this lucky mutation occuring. They probably had so many problems with their coiling!!! (sarcasm) Atom

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