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Is it the “junk DNA” that makes us human?

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Skin cells repurposed into brain cells were studied:

Our DNA is very similar to that of the chimpanzee, which in evolutionary terms is our closest living relative. Stem cell researchers at Lund University in Sweden have now found a previously overlooked part of our DNA, so-called non-coded DNA, that appears to contribute to a difference which, despite all our similarities, may explain why our brains work differently. The study is published in the journal Cell Stem Cell…

Using the stem cells, the researchers specifically grew brain cells from humans and chimpanzees and compared the two cell types. The researchers then found that humans and chimpanzees use a part of their DNA in different ways, which appears to play a considerable role in the development of our brains.

“The part of our DNA identified as different was unexpected. It was a so-called structural variant of DNA that were previously called “junk DNA,” a long repetitive DNA string which has long been deemed to have no function. Previously, researchers have looked for answers in the part of the DNA where the protein-producing genes are — which only makes up about two per cent of our entire DNA — and examined the proteins themselves to find examples of differences.”

The new findings thus indicate that the differences appear to lie outside the protein-coding genes in what has been labelled as “junk DNA,” which was thought to have no function and which constitutes the majority of our DNA.

“This suggests that the basis for the human brain’s evolution are genetic mechanisms that are probably a lot more complex than previously thought, as it was supposed that the answer was in those two per cent of the genetic DNA. Our results indicate that what has been significant for the brain’s development is instead perhaps hidden in the overlooked 98 per cent, which appears to be important. This is a surprising finding.”

Lund University, “What makes us human? The answer may be found in overlooked DNA” at ScienceDaily (October 8, 2021)

The question “What makes us human?” is problematic in principle. It seems as if researchers are looking for a switch: Click! Now it’s human. There’s a lot that that approach won’t account for.

The paper is open access.

You may also wish to read: Term “junk DNA” critiqued at journal. But now remember the history! “The days of ‘junk DNA’ are over…”? So the house is clearly supporting this move away from the Darwinian position. Oh yes, let’s not forget that “junk DNA” was very much a Darwinian position. Most or all of the Darwinian Bigs signed onto junk DNA as part of their thesis about the unguided nature of life. The big question will doubtless be put off for now: Why does it only count if Darwinian predictions are right but never if they are wrong?

Casey Luskin reflects on the “official” demise of the term “junk DNA.” Luskin: “these authors remember a day when ‘the common doctrine was that the nonprotein coding part of eukaryotic genome’ consisted of ‘“useless sequences, often organized in repetitive elements.’” Good. Keep the history alive. It won’t be very long before Darwinians start claiming that they never thought it was junk. Then they will start insinuating that WE said it was junk. No, that doesn’t make any sense but if the history is forgotten, it doesn’t need to either.

and

And now … Transposable elements (junk DNA) shape the evolution of mammalian development. No wonder people are backing away from the Darwinian staple of junk DNA. We wonder, when will the pop science articles start to appear, claiming that junk DNA was never really an argument used by Darwinian evolutionists in support of their cause and that, in any event, they were right to use such an argument.

Comments
@6 JVL:
The basic idea is that bits of the genome are activated based on exterior influences.
The information on how to build a brain must reside somewhere, right? And, obviously, you are not saying that it is stored in 'exterior influences'. JVL:
So, the genome is not a blue-print, more like a cooking recipe: when this is true do this, etc.
This makes no difference to the problem. In the cooking recipe scenario, the information on how to build a brain is in the instructions [when this is true do this, etc]. So my question remains essentially the same: given that 98% of our genome is junk, where is this "cooking recipe" information stored? p.s. And BTW how do we get the right 'cooking-instructions' to the right cells, at the right time?Origenes
October 22, 2021
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Neither Dawkins nor Shubin know what makes an organism what it is. They are just liars for evolutionism. They don't have any idea how metazoans arose. They have nothing beyond a narrative based on their very biased, but untestable, ideas.ET
October 22, 2021
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A more gene focused article by Wilcox
Our Genetic Prehistory: Did Genes Make Us Human?
https://www.asa3.org/ASA/PSCF/2014/PSCF6-14Wilcox.pdf I would take his theology as his personal beliefs but the references to gene development and gene expression are what is interesting.jerry
October 22, 2021
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Origenes: There is no need for the information to build brains and body? What are these people thinking? Dr Dawkins did a pretty good job explaining that issue in The Greatest Show on Earth and Dr Neil Shubin also explains and updates that area in his book Some Assembly Required. The basic idea is that bits of the genome are activated based on exterior influences. Dr Dawkins metaphor is to think of a flock of birds: the whole flock ends up sometimes creating complicated aerial patterns even though each bird is only responding to its local input. So, the genome is not a blue-print, more like a cooking recipe: when this is true do this, etc.JVL
October 22, 2021
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DNA doesn't make us human.ET
October 22, 2021
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I'm surprised at how soon we forget. Or maybe people want to forget David Wilcox. I believe he is a theistic evolutionist and now is very old. But he is one of the most knowledgeable persons in the world on human evolution. Or what makes humans different from all other species. Here is webpage and he hasn't published in several years. https://www.eastern.edu/david-wilcox His articles are religious in focus but in them all the biological details are laid out in long articles. The last one of his list https://www.asa3.org/ASA/PSCF/2016/PSCF3-16Wilcox.pdf I will leave the Junk DNA junkies to pour through it. I haven't the time to do so. But one excerpt
As for the genetic evidence, the unique character of the human mind is not due to a “magic genetic bullet.” There are not just a few major alterations, not just the injection of a “new” set of genes—although some new loci have been identified. Rather, based on differences with the chimpanzee genome, human neural development depends on the wholesale alteration of the control sequences of the majority of the genes acting in the brain. More than one hundred neural loci show signs of high selection, and most are upregulated and delayed in expression. Humans’ neural loci also have higher levels of alternate gene splicing (hence producing a more diverse array of proteins) and altered neural epigenetic markers. Most of these differences are in loci controlling neural development. Much of this variation has been generated by transposon-driven mutation (ALUs— or jumping genes). As to how this pattern evolved, it seems obvious to point to a selective regime favoring neural complexity. But that is an empty description. The real question for evolution would be, what circumstances would produce such a regime?
jerry
October 22, 2021
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Our results indicate that what has been significant for the brain’s development is instead perhaps hidden in the overlooked 98 per cent, which appears to be important. This is a surprising finding.”
The “overlooked 98 per cent”?? I find it inconceivable, that serious scientists are capable of believing that the massive information necessary for building the human body can reside in just 2% of the DNA. But wait, that isn't what they believe at all. Once I asked Larry Moran:
If most of our genome is junk, then where is the information stored for the (adult) body plan? Where is the information stored for e.g. the brain? And where is the information stored for how to build all this?
Larry Moran’s astonishing answer:
(…) experts do not see a need to encode body plans and brain in our genome (…)
There is no need for the information to build brains and body? What are these people thinking?Origenes
October 22, 2021
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The new findings thus indicate that the differences appear to lie outside the protein-coding genes in what has been labelled as “junk DNA,” which was thought to have no function and which constitutes the majority of our DNA.
such an irony ... not the coding-part of the genome (you know, the self-fish gene), but the 'junk' in our genome is what makes us the most sophisticated species able to send probes to Mars ... PS: and, of course, here we go again: " .... a lot more complex than previously thought...." or " ...This is a surprising finding..."martin_r
October 22, 2021
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From an engineering viewpoint it wouldn't take a lot of altered commands. The cortex is built from the brainstem by a set of instructions. The instructions tell the radial glia how to arrange themselves, and then the brainstem generates a few billion neurons and sends them out on the radial glia like settlers following railroad tracks into a new territory. The map for the railroads is probably built by a mapmaker, not directly from the genes. So a single instruction is really all you'd need. "Memo to railroad mapping service: Use map H instead of map C".polistra
October 21, 2021
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