Not only is evolution a fact beyond all reasonable doubt, it also is essential to ones understanding of biology. Indeed, without evolution, science itself would be impossible. These are the pronouncements of evolutionists who even go so far as to define life as the ability to evolve. Given these truths one would think that evolutionary theory would be rather important for research in the life sciences. Is not the evolutionary framework a necessary starting point? Surprisingly scientific progress consistently is made without evolution leading the way or even pointing in the right direction. Often evolutionists are surprised by the science and new evolutionary explanations are tacked on after the fact rather than providing the initial insight. Other times evolution simply is not even mentioned as it simply makes no sense on the science. Read more
12 Replies to “Regulating the Regulators: A Single Arginine Insertion in the Glucocorticoid Receptor Changes Protein Expression”
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Thanks for this post and you other post Dr. Hunter.
Stephen L Talbott: “When regulators are in turn regulated, what do we mean by “regulate” — and where within the web of regulation can we single out a master controller capable of dictating cellular fates? And if we can’t, what are reputable scientists doing when they claim to have identified such a controller, or, rather, various such controllers?
If they really mean something like “influencers,” then that’s fine. But influence is not about mechanism and control; the things at issue just don’t have controlling powers. What we see, rather, is a continual mutual adaptation, interaction, and coordination that occurs from above. What we see, that is — once we start following out all the interactions at a molecular level — is not some mechanism dictating the fate or controlling an activity of the organism, but simply an organism-wide coherence — a living, metamorphosing form of activity — within which the more or less distinct partial activities find their proper place. The misrepresentation of this organic coherence in favor of supposed controlling mechanisms is not an innocent inattention to language; it’s a fundamental misrepresentation of reality at the central point where we are challenged to understand the character of living things.”
Box, timely quote from Talbott! Talbott has a gift for focusing on the ‘elephant in the living room’ that is constantly ignored in molecular biology. Namely regulation and control must be a ‘top down’ holistic process. A ‘top down’ process that takes the whole of the cell or organism into consideration. It is impossible in principle, contrary to what the central dogma of Darwinism may maintain, for an organism or cell to be regulated or controlled solely in a ‘bottom up’ fashion. Empirical evidence is finally catching up as Denis Nobel has recently noted:
Bornagain77,
Talbott is very convincing when he addresses the ‘elephant’, isn’t he? Maybe dr.Hunter would care to comment on Talbott’s holism?
//Follow up:
Searching ‘the master controller capable of dictating cellular fates’ seems similar to searching for the First Cause – Aquinas Unmoved Mover.
Box as to:
Pardon my elementary knowledge of philosophy, but, as far as what is ‘the master controller capable of dictating cellular fates’ is, I, as far as the empirical evidence would allow me, arrived at the ‘soul’ for describing ‘the master controller capable of dictating cellular fates’:
A few notes along the line of ‘oneness’ arising from an almost countless myriad of molecular parts and cells:
Verse and Music:
Bornagain77,
Does Hameroff’s line of reasoning entail that the spiritual mind (soul) connects to the body at quantum level?
Well Box, as far as I can tell, Dr. Hameroff holds to a metaphysics that is based in large part on Eastern pantheism (which, IMHO, gets him in trouble on larger issues such as the origin of material reality itself). But that being said, and again as far as I can tell, and forgive me if I’m wrong, but I do believe he holds that consciousness/spiritual mind (or even ‘soul’) connects at the ‘quantum’ level. In fact, he has a fairly long history of being very antagonistic to the reductive materialist’s position. Note the title of this following article by Hameroff in which he hypothesizes about what happens to the soul upon death:
Also of note, Hameroff’s infamous Orch-Or model (microtubules) for quantum consciousness has very recently received preliminary confirmation from, as far as I know, the first direct test for it:
Bornagain77,
thank you very much for your patience and fascinating information. These are interesting times.
It’s very interesting to see that when we study the universe and follow a chain of events towards the big bang, or when we study the cell and follow regulators, who regulate regulators, in search of a master controller, or when we split matter into tiny bits in search for fundamental material reality the same thing happens:
We are confronted with what we cannot explain with good old cause an effect: ‘Unmoved Mover’, ‘Holism’, ‘Beyond Space and Time’.
OT: New Paper states atmospheric oxygen was present on Earth much earlier than Darwinists were forced to presuppose:
Oxygen, the Scourge of Evolution – Oct. 10, 2013
Excerpt: The scourge of evolution has re-emerged?this time with renewed vengeance. Scientists have long known that extremely low levels of free-oxygen [< 10-5] atmosphere on early Earth is critical for any viable origin of life model of evolution.,,,
Geophysicist Stephen C. Meyer of the University of Cambridge notes in Signature in the Cell that “even a small amount of atmospheric oxygen will quench the production of biologically significant building blocks and cause biomolecules otherwise present to degrade rapidly.” ,,,
History of Early Earth Free-Oxygen Theory
One of the first to throw the wrench into the GOE theory was geologist Harrison Brown of the University of Chicago in the 1960s, noting that stellar atmosphere vanished or never existed on Earth.
By the 1970s, Philip Abelson of the Carnegie Institution gave a simple Q&A: “What is the evidence for a primitive methane-ammonia atmosphere on Earth? The answer is that there is no evidence for it, but much against it.”
Later in the 1970s, Canadian geologists Erich Dimroth and Michael Kimberly issued the following finding: “In general, we find no evidence in the sedimentary distributions of carbon, sulfur, uranium, or iron, that an oxygen-free atmosphere has existed at any time during the span of geological history recorded in well-preserved sedimentary rocks.”
Belgium Biochemist, Marcel Florkin, joined Dimroth and Kimberly in 1975 noting that “the concept of a reducing primitive atmosphere has been abandoned,” and the Miller–Urey experiment is “not now considered geologically adequate.”
Even molecular biologists, Sidney Fox and Klaus Dose, joined the discussion in 1977 declaring, “The inference that Miller’s synthesis does not have a geological relevance has become increasingly widespread.”
In 1982, British geologists Harry Clemmey and Nick Badham after examining the evidence from the rocks proclaimed, “From the time of the earliest dated rocks at 3.7 billion years, Earth had an oxygenic atmosphere.”
By 1995, Jon Cohen, senior editor for Science, the flagship journal of the American Association for the Advancement of Science (AAAS) announced, “The early atmosphere looked nothing like the Miller–Urey simulation.”
With the evidence became too massive to ignore any longer, in 1998 Richard Monastersky, writing for the National Geographicfinally broadcast, “Many scientists now suspect that the early atmosphere was very different from what Miller first supposed.”
(New) Scientific Evidence for Early Earth Free-Oxygen Theory
An international research team led by Sean Crowe University of Southern Denmark in September (2013) published in the journal Nature a paper re-establishing the presence of atmospheric oxygen on early Earth. The team representing the nations of Denmark, South Africa, and Germany discovered oxygen to exceed 30-times beyond the critical concentration of < 10^-5.
http://www.darwinthenandnow.co.....olution-4/
Box: Great point by Talbott, thanks for pointing that out.