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At Oscillations: How the College Board skews students toward Darwinism

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https://www.amazon.com/Darwin-Overthrown-Mechanobiology-Suzan-Mazur/dp/0578452669

Suzan Mazur, an independent journalist and author of Darwin Overthrown: Hello Mechanobiology, takes aim at the outdated Darwinism of the College Board university preparation system:

At Oscillations, she notes that the content of its biology course and exam framework devotes 24 pages or 22% to Darwinian natural selection and describes it in the “Essential Knowledge” section as “a major mechanism of evolution.” The College Board, she reports, explicitly says that: “The principles of natural selection and its components appear throughout the course.”

She sees this as a “catastrophe” (Suzan Mazur, “College Board & The Natural Selection Racket” at Oscillations) because “the evolution paradigm has shifted” and – following Eugene Koonin – natural selection is not taken seriously any more as an explain-all.

The_Paradigm_Shifters_470

Is the stuff she identifies designed to insulate students from the ferment going on in biology or is just the outcome of educrats’ self-insulation…? Maybe both?

Mazur has got to be one of the best-connected people writing about evolution today. Her nose for haven’t-we-seen-this-show-before?, oh-not-THAT-again?, used-to-was, done-to-death, and this-will-wash-no-more is the outcome of having interviewed many movers and shakers (and maybe some slackers and fakers) and kept notes over the years. She should certainly be better known.

The Paradigm Shifters: Overthrowing ‘the Hegemony of the Culture of Darwin’ is also a good introduction to what’s changing in biology.

Comments
Alexa ranks for related websites today: EN:……..249,394………………1 TO:……...445,086……………….1 UD:……...596,534………………1 SW:……..987,052……………..1 PT:…….2,303,225………….…3 TSZ:….8,929,355………….…9jawa
February 29, 2020
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Will "Ed George" ever tire of being a pathological liar and scientifically illiterate coward? The Las Vegas odds say "No". :razz:ET
February 29, 2020
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"Ed George" is lying again. I am not the only person that has been banned from TSZ. I am the only person who has been banned from TSZ for exposing the evos there as liars and cowards. I was banned from SW for the same reason. I was banned from UD for that exact reason. And I am more than OK with that. At least I don't get banned for being an insipid troll, like "Ed George".ET
February 29, 2020
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Jawa, maybe Alexa keeps track of who gets banned from various sites and de-links any association that person may have had with that site. That would certainly explain why IR is not associated with any of these sites. The owner of IR has been banned from all of these sites, some multiple times. In fact, he is on record of being the only person to ever be banned from TSZ, and he was banned there on three different occasions.Ed George
February 29, 2020
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What disrespectful titles? What makes them disrespectful? Why isn't that the people written about are disrespectful and being called out on it? Most likely the titles are just astute observations. And some people just cannot deal with that reality.ET
February 29, 2020
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Ed George @217: I have no idea how they do it. The whole thing is interesting to me, that's why I'm writing about it. I had AiG and RTB in the list but later removed them after noticing that Alexa did not show any explicit association between them. In my opinion they are related, but I wanted to be consistent. Perhaps the disrespectful titles disqualified the website by Alexa's standards. I don't know. I don't understand why I don't see explicit relation between TO and PT and SW. Unless I missed it?jawa
February 29, 2020
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For the record- SW only discusses a strawman version of ID. Larry Moran remains willfully ignorant of ID and can only attack caricatures. And he will never produce any evidence that supports evolution by means of blind and mindless processes' ability to produce complex protein machinery. So there's that.ET
February 29, 2020
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Is it possible that Alexa uses an algorithm to classify people based on their posts and has accurately classified "Ed George" as a crank, pathological liar and attention demanding narcissist with Tourette’s? It's not only possible it is a 100% correct assessment of the insipid troll named "Ed George".ET
February 29, 2020
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Jawa
Again, the blog you cited @204 doesn’t show any explicit association with the list @203 in the Alexa stats.
How does Alexa determine if two sites have explicit association? SW and Intelligent Reasoning are personal blogs with all OPs written by the blog owner. They both frequently discuss ID and evolution. They both allow comments. Their owners both have posted at UD. Commenters and authors at UD have commented at both. Is it possible that Alexa uses an algorithm to classify blogs based on the titles of the OPs, and has accurately classified IR as a crank site run by an attention demanding narcissist with Tourette’s?Ed George
February 29, 2020
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"Ed George":
That blog is hosted by a well known narcissistic bully.
So sez the well-known pathological liar.
The fact that UD continues to allow this person to comment at UD, with full knowledge of his propensities, simply detracts from any legitimate reputation that the site desires.
So sez the well-known pathological liar with a loser reputation. I am comfortable with the fact that "Ed George" cannot support either of those claims.ET
February 29, 2020
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Jawa:
BTW, the titles of those posts @204 are disrespectful,...
No, they are not disrespectful. They expose disrespectful people.
which indicate that blog is not serious.
That doesn't followET
February 29, 2020
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@213 Ed George
That blog is hosted by a well known narcissistic bully.
Second best coyne description I have ever read.Truthfreedom
February 29, 2020
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Ed George, Again, the blog you cited @204 doesn’t show any explicit association with the list @203 in the Alexa stats. note the associations shown in the Alexa stats: EN: TO, UD, 864 TO: EN, 2,757 UD: EN, TSZ, 652 PT: UD, 1,022 SW: UD, 473 TSZ: UD, PS, 44 PS: TSZ, 15jawa
February 28, 2020
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Jawa
BTW, the titles of those posts @204 are disrespectful, which indicate that blog is not serious.
I agree. That blog is hosted by a well known narcissistic bully. I selected it simply because, as with UD, it claims to serve the ID community.
Distinguished contributors to SW, PT and TSZ have posted comments in UD. EN and UD are very related too. TO is related to SW and PT.
But the host of Intelligent Reasoning is also a regular and frequent commenter at UD. The fact that UD continues to allow this person to comment at UD, with full knowledge of his propensities, simply detracts from any legitimate reputation that the site desires.Ed George
February 28, 2020
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Ed George @204: This time you're not comparing apples and alligators @204, but apples and almonds, which is closer, but not there yet. The website you cited @204 is not related to the websites @203 according to Alexa stats. BTW, the titles of those posts @204 are disrespectful, which indicate that blog is not serious. Distinguished contributors to SW, PT and TSZ have posted comments in UD. EN and UD are very related too. TO is related to SW and PT. Also note the associations shown in the Alexa stats: EN: TO, UD, 864 TO: EN, 2,757 UD: EN, TSZ, 652 PT: UD, 1,022 SW: UD, 473 TSZ: UD, PS, 44 PS: TSZ, 15jawa
February 28, 2020
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Alexa ranks for related websites today: EN:……..248,042………………1 TO:……..445,114……………….1 UD:……..596,778………………1 SW:…....987,330……………..1 PT:……2,304,245………….…3 TSZ:….8,923,577………….…9 SW has experienced an impressive rebound. TSZ keeps sinking. PS still off the radar.jawa
February 28, 2020
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@202 OLV: They say 'complexity' but do not bother to explain the meaning.Truthfreedom
February 28, 2020
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@205 Ed George
jerry coyne is an Imbecile and a Liar!
Best coyne description I have ever read.Truthfreedom
February 28, 2020
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Cowardly and willfully ignorant "Ed George" strikes again. It actually thinks that arguments are laid out in a blog post TITLE. How desperately ignorant is "Ed George"? "Ed George" is too much of a punk to respond to the quality and reasoned arguments in the titles it mined. It doesn't know what reasoning is. Heck "Ed George" was recently caught in a major lie on this forum. That is the truth of "Ed George"- pathological liar and crybaby loser.ET
February 28, 2020
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Ed George @204: That’s an interesting point. Thanks for bringing it up here. Before I can respond your comment, please help me to locate the following information: What relation does Alexa show between that blog you cited @204 and the ones referenced in the list @203? IOW, which of the blogs referenced @203 are mentioned by Alexa in the stats for the blog you cited @204? Or is the blog you cited @204 mentioned in the Alexa stats for any of the blogs referenced @203? BTW, the Alexa stats don’t seem to imply quality level. It’s just about internet traffic and engagement. I removed AiG and RTB from the list because I didn’t see any relation (in the Alexa stats) with the other websites. PS. Apparently appearing in the top 5 most popular threads attracts more visits to the thread. Also apparently having comments in the recent list also attracts more visits to the thread. But maybe that’s not the case?jawa
February 27, 2020
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Or the Darwin’s God site that has been moribund since October 2019. 6,923,149 Or Bio-Complexity, ID’s flag-ship journal that has not published anything this year, and only three articles last Year 3,854, 210 There does not seem to be any rhyme or reason behind these rankings. At least at this level of granularity. To compare this to a relatively obscure and niche journal, Accreditation and Quality Assurance. 522Ed George
February 27, 2020
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Don’t forget Intelligent reasoning’s ranking (6,842,631). Better than TSZ’s. It must be because of the quality and reasoned arguments in OPs such as the following:
Joshua Swamidass is Full of Shit Patrick Trischitta is an Ignorant Bitch! Jerry Coyne is an Imbecile and a Liar! Faizal Ali- Proud to be an Ignorant Ass.
Again, I wouldn’t read too much, if anything, into these rankings. And, in this case, I am not comparing apples and alligators.Ed George
February 27, 2020
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Alexa ranks for related websites today: EN:……..246,933………………1 TO:……..442,478……………….1 UD:……..594,480………………1 SW:…..1,020,416………….....2 PT:……2,306,737………….…3 TSZ:….8,920,001………….…9 Note that SW has improved its rank substantially while TSZ has worsen it badly. Any idea why?jawa
February 27, 2020
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Truthfreedom @199: Do they mean structural complexity, functional complexity, architectural complexity, logical complexity, mathematical complexity, or a combination of them? Are their arguments related to some of the papers cited @198 (in response to PU@197)? Later I'll try to come back to review those papers here.OLV
February 27, 2020
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More ID: Multifaceted roles of microRNAs
Two crucial questions in neuroscience are how neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are vulnerable to neurodegenerative diseases. In the central nervous system, spinal motor neurons serve as one of the best-characterized cell types for addressing these two questions.
How neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are susceptible to degeneration in neurodegenerative disease are two challenging unanswered questions in neuroscience.
The relevance of miRNAs to development and disease contexts has been gaining increasing attention over the past two decades.
     OLV
February 26, 2020
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More evidence for ID: Large-Scale Analysis of the Diversity and Complexity of the Adult Spinal Cord Neurotransmitter Typology
neurotransmitter co-expression is much more extensive than previously assumed, suggesting that spinal networks are more complex than first recognized.
These studies shed new light on the diverse and complex functions of this important interneuron class in the neuronal interplay governing the precise operation of the central pattern generators.
Neuronal networks in the spinal cord are able and sufficient to generate and control movements and receive and process sensory information
Their functionality depends on the correct specification of different classes of neurons during development, which allows them to establish precise connections. Spinal neurons derive from specific progenitor pools in the spinal cord and express precisely a combination of transcription factors
Neuronal communication involves the release and uptake of specific neurotransmitters, endogenous chemical messengers used in intercellular signaling across synapses.
Neurons can be classified as excitatory, inhibitory, or modulatory based on their neurotransmitter phenotypes. Therefore, the adoption of a specific neurotransmitter system by a given neuron type defines its identity.
Our results reveal a previously unsuspected co-expression of different neurotransmitters in spinal cord neurons
these multi-phenotype neurons are far more numerous and widely distributed in the spinal cord than previously assumed.
The comprehensive neurotransmitter typology atlas presented here reveals an unforeseen diversity, complexity, and dynamics in the principles that govern the structural organization of the adult zebrafish spinal cord
Signal transmission in neuronal networks involves the release of neurotransmitters that bind specifically to membrane receptors on target neurons to mediate basic and complex biological functions.
it is essential to understand the genetic programs that specify an individual neuron's type and transmitter expression.
neuronal populations in vertebrate and invertebrate nervous systems use multiple transmitter systems simultaneously.
the prevalence and physiological roles of co-transmission remain poorly understood, as is the synaptic circuitry involved.
additional neurotransmitters mediate the neuronal interplay needed for the precise operation of the central pattern generators
our study may be considered conservative and underestimate the full neurotransmitter complexity that exists in the vertebrate spinal neurons.
OLV
February 26, 2020
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@194 OLV:
What do they mean by “complexity”?
That is a good question, having in mind that most of those people are philosophically illiterate and do not even really understand what they are trying to communicate, apart from saying illogical and contradictory things all the time/ parroting their leaders. According to them, "complexity" equals no design. I'll ask them to define the term, because without a clear definition, their statement makes no sense :) (Not surprising and not that they care). Thank you and beautiful links.Truthfreedom
February 26, 2020
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Do these papers raise valid arguments against design?   Really? Let's check and see... Is the cell really a machine? Highlights • Self-organization plays a key role in specifying the cellular architecture. • Most proteins are functionally promiscuous and interact opportunistically. • Directed movement occurs in the absence of design by generating order out of chaos. • The non-genetic heterogeneity of cell populations implies that every cell is unique. • Physics, not engineering, proves most helpful in understanding cellular complexity. Abstract
It has become customary to conceptualize the living cell as an intricate piece of machinery, different to a man-made machine only in terms of its superior complexity. This familiar understanding grounds the conviction that a cell's organization can be explained reductionistically, as well as the idea that its molecular pathways can be construed as deterministic circuits. The machine conception of the cell owes a great deal of its success to the methods traditionally used in molecular biology. However, the recent introduction of novel experimental techniques capable of tracking individual molecules within cells in real time is leading to the rapid accumulation of data that are inconsistent with an engineering view of the cell. This paper examines four major domains of current research in which the challenges to the machine conception of the cell are particularly pronounced: cellular architecture, protein complexes, intracellular transport, and cellular behaviour. It argues that a new theoretical understanding of the cell is emerging from the study of these phenomena which emphasizes the dynamic, self-organizing nature of its constitution, the fluidity and plasticity of its components, and the stochasticity and non-linearity of its underlying processes.
Contrasting theories of life: Historical context, current theories. In search of an ideal theory Highlights • Several modern theories of the essence of life exist. • These were developed essentially independently of one another. • They include some common themes, notably the idea of closure. • All lack a system of regulation to prevent uncontrolled growth.   Abstract
Most attempts to define life have concentrated on individual theories, mentioning others hardly at all, but here we compare all of the major current theories. We begin by asking how we know that an entity is alive, and continue by describing the contributions of La Mettrie, Burke, Leduc, Herrera, Bahadur, D’Arcy Thompson and, especially, Schrödinger, whose book What is Life? is a vital starting point. We then briefly describe and discuss (M, R) systems, the hypercycle, the chemoton, autopoiesis and autocatalytic sets. All of these incorporate the idea of circularity to some extent, but all of them fail to take account of mechanisms of metabolic regulation, which we regard as crucial if an organism is to avoid collapsing into a mass of unregulated reactions. In a final section we study the extent to which each of the current theories can aid in the search for a more complete theory of life, and explain the characteristics of metabolic control analysis that make it essential for an adequate understanding of organisms.
  In pursuit of the framework behind the biosphere: S-curves, self-assembly and the genetic entropy paradox Abstract
The origins, evolution and functioning of the Biosphere have occupied humankind for as long as recorded history has existed. In this paper we examine the claims of thermodynamics to be the framework within which we can understand the evolution, functioning and development of the Biosphere, exploring the evidence from ecology, molecular science and evolutionary biology, and particularly focussing upon the maximum entropy production principle (MEPP), and its explanatory potential in terms of many of the logistic relationships found within the Biosphere. We introduce the genetic entropy paradox, where the DNA increases in terms of internal information entropy, as the genetic code is continuously randomized through mutation, and yet this leads to increasing external entropy production, as increasingly more complicated structures and functions are produced in the form of new protein morphologies and metabolic pathways (again determined by the bioenergetic context). We suggest that the central dogma acts as a form of entropy exchange mechanism, but at the core of this is change in information entropy, which increases within the genetic code, and decreases within the organism. This would appear to be a truly unique event, and highlights a key interaction between two levels of organization within the Biosphere, the genome and the proteome, in terms of entropy production. The Biosphere is seen as being composed of a series of self-organizing sub-groups, each maximizing entropy production within the constraints of time, feedback and system constraints. The entropic production of the Biosphere is thus an emergent property.
The Second Special Issue on Code Biology — An overview Cell differentiation: What have we learned in 50 years? Modeling somatic computation with non-neural bioelectric networks Pathways to cellular supremacy in biocomputing Evidence That Ion-Based Signaling Initiating at the Cell Surface Can Potentially Influence Chromatin Dynamics and Chromatin-Bound Proteins in the Nucleus Naive extrapolations, overhyped claims and empty promises in ageing research and interventions need avoidance Modeling somatic computation with non-neural bioelectric networks Pathways to cellular supremacy in biocomputing A finite vocabulary of antibody-antigen interaction enables predictability of paratope-epitope binding Are Microbes Thermodynamically Optimised Self-Reproducing Machines?            OLV
February 26, 2020
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Is this what Truthfreedom referred to? This paper seems to raise strong arguments against ID: https://www.sciencedirect.com/science/article/abs/pii/S0022519319302292?via%3DihubPavelU
February 26, 2020
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More evidences supporting ID: Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord
The coordinated spatial and temporal regulation of gene expression in the vertebrate neural tube determines the identity of neural progenitors and the function and physiology of the neurons they generate. Progress has been made deciphering the gene regulatory programmes that are responsible for this process; however, the complexity of the tissue has hampered the systematic analysis of the network and the underlying mechanisms.
the analysis highlighted a previously underappreciated temporal component to the mechanisms that generate neuronal diversity, and revealed common features in the sequence of transcriptional events that lead to the differentiation of specific neuronal subtypes.
Neuronal circuits in the spinal cord receive and process incoming sensory information from the periphery, and control motor output to coordinate movement and locomotion
Although aspects of the gene regulatory network that controls neural tube patterning and neuronal differentiation have been characterised, there remain substantial gaps in our knowledge. It is unclear whether the complete catalogue of transcriptional regulators that define cell types has been established. Whether there are features in common between the mechanisms that promote the differentiation of distinct neuronal subtypes is not known. Similarly, the alterations in gene expression that accompany temporal changes in progenitor competence and cell type generation are poorly documented.
Although much progress has been made to reverse engineer the gene regulatory network that is responsible for pattern formation and cell fate specification in the neural tube [...], it remains incomplete.
Analysis of the single cell transcriptome dataset revealed a set of gene expression modules that is activated synchronously at characteristic developmental timepoints in multiple neuronal classes. This raises the possibility of a coordinated temporal transcriptional programme that subdivides neuronal classes based on their time of generation. Such a mechanism would operate in parallel to the spatial patterning mechanisms and provide an opportunity to increase the molecular and functional diversity of cell types that are generated in the neural tube.
multiple secreted signalling molecules may determine into which neuronal subtypes progenitors in the spinal cord differentiate at specific timepoints.
The analysis suggests a temporal axis that contributes to the neuronal diversity that accompanies the well-characterised spatial patterning of neural progenitors.
OLV
February 25, 2020
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