# The “beautiful mechanism” by which an egg becomes an embryo

July 11, 2017 | Posted by News under Cell biology, Intelligent Design |

From Phys.org:

The transition from an egg to a developing embryo is one of life’s most remarkable transformations. Yet little is known about it. Now Whitehead Institute researchers have deciphered how one aspect—control of the all-important translation of messenger RNAs (mRNAs) into proteins—switches as the egg becomes an embryo. That shift is controlled by a beautiful mechanism, which is triggered at a precise moment in development and automatically shuts itself off after a narrow window of 20 to 90 minutes.

As an egg develops, it stockpiles mRNAs from the mother because it will not have time to create new mRNAs during the rapid development of a very early embryo. When fertilized the egg becomes an embryo, the stashed maternal mRNAs are pressed into service for a brief window before the embryo starts transcribing its own mRNAs. This change occurs very early; in humans, only two to four cell divisions occur before this transition is executed. Whitehead Member Terry Orr-Weaver studies the control of translation of maternal mRNAs in the model organism Drosophila, or the fruit fly, because its developmental strategy offers experimental advantages. More.

A reader writes to note that the “beautiful mechanism” is described as a

negative feedback loop,” with the same function as those designed in engineering control systems: Furthermore, the activity of PNG kinase leads to the destruction of GNU, and this feedback loop limits this kinase’s activity to the narrow window of time in which it is needed.

“Active PNG leads to decreased GNU protein levels. This makes a negative feedback to shut down PNG kinase activity, thereby ensuring PNG kinase activity is constrained to the short developmental window of the oocyte-to-embryo transition

Another reader who forwarded this item points out that the authors let in the “d” word (and I don’t mean “Darwin”…. ):

The design of this transition could tell scientists more about how human cells work and embryos develop. For example, the switch could be a model for how cells massively and globally change mRNA translation. Also, similar kinase activity during early development has been noted in worms, which may mean that a comparable approach is used in other organisms, including humans.

Well, if the researchers’ careers take a beating for mentioning design, they will need to join the Free the Universities movement. After a while language Stalinism starts t collapse from its own uncommunicativeness and one must peak clearly again.

*See also:* Cells communicate to navigate a crowded embryo

### 298 Responses to *The “beautiful mechanism” by which an egg becomes an embryo*

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Interesting paper. Thanks.

Complex complexity

Complex complexity

Complex complexity

Complex complexity

Did somebody say “Strikingly”?

Complex complexity

Elegant switch controls translation in transition from egg to embryo

http://wi.mit.edu/news/archive.....egg-embryo

perhaps when they write ‘design’ they really mean ‘appearance’?

appearances can be deceiving, can’t they? 🙂

Functional Amyloids in Reproduction

Aveline Hewetson 1, Hoa Quynh Do 1, Caitlyn Myers 1, Archana Muthusubramanian 1, Roger Bryan Sutton 2, Benjamin J. Wylie 3 and Gail A. Cornwall

Biomolecules 2017, 7(3), 46;

doi:10.3390/biom7030046

“nature favors the amyloid fold for these processes”?

“nature favors”?

huh?

Complex functional complexity

Complex functional complexity

Complex functional complexity

Complex functionally specified informational complexity.

🙂

“The future of genetic codes and BRAIN codes”

Presentation by professor George M. Church at NIH

2017-Feb-08 @3pm

https://videocast.nih.gov/summary.asp?Live=21803&bhcp=1

@55:30 [in response to a question]

@56:15

Had we remained in Eden, none of this would have been an issue at all. Too late now.

Complex functionally specified informational complexity

Had we remained in Eden, none of this would have been an issue at all. Too late now.

Complex functionally specified informational complexity

Had we remained in Eden, none of this would have been an issue at all. Too late now.

Complex functionally specified informational complexity

Had we remained in Eden, none of this would have been an issue at all. Too late now.

Complex functionally specified informational complexity

Had we remained in Eden, none of this would have been an issue at all. Too late now.

Work in progress… stay tuned.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Had we stayed in Eden, none of this would have been an issue at all. Too late now.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Did somebody say “surprising”? 🙂

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Did somebody say “One of the challenges of the next century”? Next century?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

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Complex functionally specified informational complexity

Complex functionally specified informational complexity

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Dionisio everywhere: Incredible contributions. Brilliant. Thank you.

[emphasis added]

Complex functionally specified informational complexity

Complex functionally specified informational complexity

TWSYF @64:

It’s my pleasure. However, all I’m doing is referencing a small subset of the enormous volume of biology-related research information available out there.

The real work is done by many seriously dedicated scientists who are trying to figure out how the biological systems work. Unfortunately many of them have been brainwashed with the Darwinian obscenities inserted in otherwise interesting textbooks, thus poisoning the minds of many students.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Off topic?

https://uncommondescent.com/plants/photosynthesis-genes-source-still-unclear/#comment-636305

Those who would like to learn basic biology concepts associated with development, may benefit from watching MIT free courses by professor Hazel Sive.

Lecture 21 Development 1

Lecture 22 Development 2

Lecture 23 Stem Cells

Lecture 24 Nervous System 1

Lecture 25 Nervous System 2

Lecture 26 Nervous System 3

https://ocw.mit.edu/courses/biology/7-013-introductory-biology-spring-2013/video-lectures/lecture-21-development-1/

You may download the videos and watch them offline at your own convenience.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Work in progress… stay tuned.

Biology researchers should focus in on understanding how the marvelous biological systems function, instead of wasting time on OOL pseudoscientific hogwash.

Complex functionally specified informational complexity

As the researchers will dig deeper into their reductionist evo-devo framework, eventually they could realize that the currently-accepted metaphysical models can’t explain the “surprising” and “unexpected” discoveries they’ll make.

Complex functionally specified informational complexity

casual? Did the author mean “causal” instead?How many people read the abstract of this paper before it was approved for publishing? Proofreaders? Peer-reviewers? Did they read the text carefully?

They seem struggling with complex functionally specified informational complexity. Poor things.

casual? Did the author mean “causal” instead?How many people read the abstract of this paper before it was approved for publishing? Proofreaders? Peer-reviewers? Did they read the text carefully? At least the abstract? Do they pay attention to details? How much attention? Do they know that “

casual” means something different than “causal” ?They seem struggling with complex functionally specified informational complexity. Poor things.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

This was over 4 years ago. What’s the situation now?

This was over 4 years ago. What’s the situation now?

This was over 4 years ago. What’s the situation now?

This was over 4 years ago. What’s the situation now?

This was over 4 years ago. What’s the situation now?

This was over 4 years ago. What’s the situation now?

This was over 4 years ago. What’s the situation now?

This was 2 years ago. What’s the situation now?

Turing, please can you explain this for us? 🙂

This was 2 years ago. What’s the situation now?

Did somebody say ‘design’? 🙂

This was 2 years ago. What’s the situation now?

Work in progress… stay tuned.

This was 2 years ago. What’s the situation now?

Did somebody say “biological engineering strategies”?

This was 2 years ago. What’s the situation now?

Complex functionally specified informational complexity

Did somebody say ‘orchestrate’?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Biological Cybernetics

Advances in Computational Neuroscience

https://link.springer.com/journal/422

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

gpuccio,

Would it be interesting to analyze the information in the proteins mentioned @116-117: Tpr, Nup153 and Nup98 ?

Thank you.

Dionisio:

Nucleoporins are a rather heterogeneous group of proteins. Most of them have some important information jump in vertebrates, and another one between amphibia and reptiles. However, they differ a lot in the amount of human-conserved information present in pre-vertebrates, which can range from almost 0 to about 1.8 bits per AA.

That said, the three proteins you mention are rather similar in their behaviour:

TPR (P12270): length: 2563 AAs

human-conserved information in pre-vertebrates: 0.4646636 baa

jump to vertebrates:

0.676259 baa, 1598 bits

NUP 98-96 complex (P52948): length 1817 AAs

human-conserved information in pre-vertebrates: 0.5701706 baa

jump to vertebrates:

0.5365988 baa, 975 bits

NUP 153 (P49790): length 1475 AAs

human-conserved information in pre-vertebrates: 0.1566102 baa

jump to vertebrates:

0.5023729 baa, 741 bits

As you can see, all of them exhibit a vertebrate jump slightly greater than 0.5 baa (about one quarter if the total potential information in the protein), which translates into absolute bit jumps ranging from 741 to 1598, according to the protein length.

While the first two proteins start with some amount of human-conserved information even in pre-vertebrates (about 0.5 baa), the third one differs, because it shows almost no human-conserved information before the vertebrate jump (0.15 baa).

However, the vertebrate jump in these proteins (ranging from 0.50 to 0.67 baa) is about double than the mean vertebrate jump in the human proteome (0.28796 baa)

Complex functionally specified informational complexity.

gpuccio,

Thank you for the detailed analysis of the given proteins.

Very interesting indeed.

Complex functionally specified informational complexity.

Did somebody say ‘Surprisingly’? 🙂

Complex functionally specified informational complexity.

Work in progress… stay tuned.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘surprisingly’?

Work in progress… stay tuned.

Complex functionally specified informational complexity.

Work in progress… stay tuned.

But I don’t like knowledge gaps, because every new discovery points to designed biological systems.

Complex functionally specified informational complexity.

Did somebody say ‘zip code’? 🙂

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘unexpected’?

Did they expect something else or nothing at all?

Complex functionally specified informational complexity.

Why largely unstudied? Lack of recourses? lack of time?

Complex functionally specified informational complexity.

Work in progress… stay tuned.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Why are they often omitted or not discussed in depth?

Can somebody provide a valid reason?

Is it lack of resources?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Work in progress… stay tuned.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

If we don’t know their function, then they must not be important.

If they don’t appear in all biological systems, then they must not be important.

Haven’t we read that kind of nonsense before?

Complex functionally specified informational complexity.

Did somebody say ‘entangled’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

This is a 4-year old paper. Let’s see how much more information on this subject has been gathered since then.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

No room for reductionist solutions?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘orchestrated’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘surprisingly’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Why does it have to be like known regulators? Where is such a rule written in?

Complex functionally specified informational complexity.

A new class of regulators?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘coordinated’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

A new regulator?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Dionisio, Heh:),

of the 202 comments so far, you have authored 200. Are you on medication?

You are interrupted twice by, Truth Will Set You Free, @64, and, gpuccio @119, other than that it is a ‘Dionisio’ love fest.

This is not a good look for ID, it points to a kind of Narcissistic personality disorder; were you bullied?

Do you even realise that there is no feedback. Afterall, we speak so as to be heard. If there are no listeners, why speak?

From all ofyour output, am I to take it that you think, all life is sacred from conception?

I disagree strongly, so your effort is wasted. The courts also agree with me. You have God and the Bible. Let’s see which is stronger?

Did somebody say ‘unexpectedly’?

What else did they expect? Why?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

“future studies will be necessary”

“it will be important to uncover the mechanisms”

As outstanding questions get answered, new questions are raised. In biology, the more we know, more is there to learn.

Complex functionally specified informational complexity.

Did somebody say ‘unexpected’?

“Our work paves the way to unveil the molecular mechanisms”

How long is that way? How much ‘paving’ work remains to be done?

Work in progress… stay tuned.

Complex functionally specified informational complexity.

Did somebody say ‘coordinate’?

Complex functionally specified informational complexity.

Did somebody say ‘controls’?

alternative mechanism? another one?

Did somebody say ‘coordinates’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

“at the right time, at the right place and in the correct number”

Did somebody say ‘strikingly’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘coordinated’?

Did somebody say ‘orchestrated’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Heh:)

wonderful. Don’t stop on my account:)

Can you make 300?

Did somebody say ‘concerted manner’?

Did somebody say ‘complexity’?

Did somebody say ‘controlled’?

Did somebody say ‘fine-tuned coordination’?

Did somebody say ‘coordinating’?

Did somebody say ‘orchestrates’?

Complex functionally specified informational complexity.

Did somebody say ‘orchestrate’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Did somebody say ‘instructions’?

Did somebody say ‘strikingly’?

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Work in progress… stay tuned.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity.

Complex functionally specified informational complexity

Did somebody say ‘preferable strategy’?

Complex functionally specified informational complexity

Did somebody say ‘preferable strategy’?

Complex functionally specified informational complexity

@236-238 the referenced paper apparently deals with plant leaves, which are relatively simpler organs.

The morphogenesis of other more complex organs is a different story, as we have seen described in a number of recent papers, where the diffusion-reaction mechanisms by themselves can’t make the morphogen gradients. Other transport mechanisms have been described in those cases.

Did somebody say ‘Surprisingly’?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Where’s the beef? 🙂

Complex functionally specified informational complexity

Where’s the beef?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Did somebody say ‘programme’?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Here’s an example of the fundamental evo-devo problem which has been formulated thus:

Dev(d) = Dev(a) + Delta(a,d)

Where

‘a’ is an ancestor biological system,

‘d’ is a descendant biological system,

Dev(x) is the entire developmental process of the biological system ‘x’

Delta(x,y) is the entire set of spatiotemporal changes required in Dev(x) in order to have Dev(y)

Where’s the beef?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

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Complex functionally specified informational complexity

Complex functionally specified informational complexity

Did somebody say ‘Strikingly’?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

The authors of this paper should have consulted a biochemistry professor who a couple of years ago in this website claimed to know exactly how to cook the whole enchilada. 🙂

But they should have asked “honest questions” (whatever that means) lest he won’t share his secret recipe. 🙂

Complex functionally specified informational complexity

Complex functionally specified informational complexity

The authors of this paper should have consulted a biochemistry professor who a couple of years ago in this website claimed to know exactly how to cook the whole enchilada. 🙂

But they should have asked “honest questions” (whatever that means) lest he won’t share his secret recipe. 🙂

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Work in progress… stay tuned.

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Did somebody say ‘programs’?

Complex functionally specified informational complexity

Did somebody say ‘intriguing’?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Did somebody say “microswitches”?

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Complex functionally specified informational complexity

Did somebody say “coordinated”?

Complex functionally specified informational complexity