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The War is Over: We Won!

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Here is the abstract from a Nature Review: Genetics paper:

The recent increase in genomic data is revealing an unexpected perspective of gene loss as a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This novel perspective of gene loss is raising new fundamental questions. How relevant has gene loss been in the divergence of phyla? How do genes change from being essential to dispensable and finally to being lost? Is gene loss mostly neutral, or can it be an effective way of adaptation? These questions are addressed, and insights are discussed from genomic studies of gene loss in populations and their relevance in evolutionary biology and biomedicine.

Many years ago, I predicted that modern genome sequencing would eventually prove one side of the argument to be right. This review article indicates that ID is the correct side of the argument. What they describe is essentially what ID scientist, Michael Behe, has termed the “First Principle of Adaptation.” (Which says that the organism will basicaly ‘break something’ or remove something in order to adapt) This paper ought to be the death-knell of Darwinism, and, of course, “neo-Darwinism,” but, even the authors who report this new “perspective” have not changed their Darwinian perspective. Somehow, they will find a way to tell us that the Darwinian ‘narrative’ always had room in it for this kind of discovery. As Max Planck said, and I paraphrase, “a theory does not prove itself right; it’s just that the scientists who opposed it eventually die.”

Here is basically the first page of the article (which is all I had access to):

Great attention has in the past been paid to the mechanisms of evolution by gene duplication (that is, neofunctionalization and subfunctionalization). By contrast, gene loss has often been associated with the loss of redundant gene duplicates without apparent functional consequences, and therefore this process has mostly been neglected as an evolutionary force. However, genomic data, which is accumulating as a result of recent technological and methodological advances, such as next-generation sequencing, is revealing a new perspective of gene loss as a pervasive source of genetic change that has great potential to cause adaptive phenotypic diversity.

Two main molecular mechanisms can lead to the loss of a gene from a given genome. First, the loss of a gene can be the consequence of an abrupt mutational event, such as an unequal crossing over during meiosis or the mobilization of a transposable or viral element that leads to the sudden physical removal of the gene from an organisms’ genome. Second, the loss of a gene can be the consequence of a slow process of accumulation of mutations during the pseudogenitzation that follows an initial loss-of-function mutation. This initial mutation can be caused by nonsense mutations that generate truncated proteins, insertions or deletions that cause a frameshift, missense mutations that affect crucial amino acid positions, changes involving splice sites that lead to aberrant transcripts or mutations in regulatory regions that abolish gene expression. In this Review, the term ‘gene loss’ is used in a broad sense, not only referring to the absence of a gene that is identified when different species are compared, but also to any allelic variant carrying a loss-of-function (that is, non-functionalization) mutation that is found within a population.

Here, we address some of the fundamental questions in evolutionary biology that have emerged from this novel perspective of evolution by gene loss. Examples from all life kingdoms are covered, from bacteria to fungi and from plants to animals, including key examples of gene loss in humans. We review how gene loss has affected the evolution of different phyla and address key questions, including how genes can become dispensable, how many of our current genes are actually dispensable, how patterns are biased, and whether the effects of gene loss are mostly neutral or whether gene loss can actually be an effective way of adaptation.

So, let’s translate what they’re saying here: “speciation” (their term is “phenotypic adaptation”) is the result of a LOSS of INFORMATION! This points, of course, to the “front-loading” of the LCA of the various branches of the so-called “Tree of Life.” Absolute bad news for Darwinism. We no longer say: “Another day; another bad day for Darwinism.” We now say: “Another day since the time Darwinism was disproved.”

This is what one of the authors has to say in an interview:

“The genome sequencing of very different organisms has shown that gene loss has been a usual phenomenon during evolution in all life cycles. In some cases, it has been proven that this loss might mean an adaptive response towards stressful situations when facing sudden environmental changes” says Professor Cristian Cañestro.

“In other cases, there are genetic losses –says Cañestro- which even though they are neutral per se, have contributed to the genetic and reproductive isolation among lineages, and thus, to speciation, or have rather participated in the sexual differentiation in contributing to the creation of a new Y chromosome. The fact that genetic loss patterns are not stochastic but rather biased in the lost genes[pav: IOW, this is where you’re going to find the genomic differences between species you compare] (depending on the kind of function of the gen or its situation in the genome in different organism groups) stresses the importance of the genetic loss in the evolution of the species.

There you have it: “evolution” through “gene loss.” I.e., “evolution” through “loss of information.” Evolution does not PRODUCE “information”; it DESTROYS “information”. You can read about in the book: “Genetic Entropy.”

In sum: the war is over, and we won! Congratulations everyone!

Comments
The Theory of Evolution is absolutely brilliant. It can predict anything in retrospect! You see, evolutionary change in a genome has actually gotta be Oscillating Over Time(tm). It expands and contracts depending on the type of selective pressure or lack thereof. Oh my! I feel the unmistakable tremor of a PhD eruption! ;-) -QQuerius
June 20, 2016
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That adaptation is driven by loss of genetic information is overwhelmingly supported by many lines of evidence. Whereas the evidence that adaptation is driven by gain of information, as is presupposed in Darwinian thought, is slim to non-existent. The only reason this finding would even be controversial is because it flies directly in the face of Darwinian presupposition. For prime example of how this flies in the face of Darwinian presuppositions we need look no farther than humans themselves. Darwin presupposed that the Caucasian race was more evolutionarily advanced than the African race:
"At some future period, not very distant as measured by centuries, the civilised races of man will almost certainly exterminate, and replace, the savage races throughout the world. At the same time the anthropomorphous apes, as Professor Schaaffhausen has remarked, will no doubt be exterminated. The break between man and his nearest allies will then be wider, for it will intervene between man in a more civilised state, as we may hope, even than the Caucasian, and some ape as low as a baboon, instead of as now between the negro or Australian and the gorilla" ? Charles Darwin, The Descent of Man, 1874, p. 178
In fact, the belief that Caucasians were the most advanced race was an integral part of Nazi racial ideology.
The Role Of Darwinism In Nazi Racial Thought - Richard Weikart - October 2013 Excerpt: The historical evidence is overwhelming that human evolution was an integral part of Nazi racial ideology. http://www.csustan.edu/history/faculty/weikart/darwinism-in-nazi-racial-thought.pdf
Yet contrary to that Darwinian presupposition of racial superiority, which was at the root of so much misery in the world in WWII, the fact of the matter is that, genetically specking, Caucasians are actually genetically inferior to Africans. Whites are not genetically superior as Darwin and the Nazis presupposed.
Human Genetic Variation Recent, Varies Among Populations - (Nov. 28, 2012) Excerpt: Nearly three-quarters of mutations in genes that code for proteins -- the workhorses of the cell -- occurred within the past 5,000 to 10,000 years,,, "One of the most interesting points is that Europeans have more new deleterious (potentially disease-causing) mutations than Africans,",,, The researchers used established bioinformatics techniques to calculate the age of more than a million changes in single base pairs (the A-T, C-G of the genetic code) that are part of the exome or protein-coding portion of the genomes (human genetic blueprint) of 6,515 people of both European-American and African-American decent.,,, http://www.sciencedaily.com/releases/2012/11/121128132259.htm "We found an enormous amount of diversity within and between the African populations, and we found much less diversity in non-African populations," Tishkoff told attendees today (Jan. 22) at the annual meeting of the American Association for the Advancement of Science in Anaheim. "Only a small subset of the diversity in Africa is found in Europe and the Middle East, and an even narrower set is found in American Indians." Tishkoff; Andrew Clark, Penn State; Kenneth Kidd, Yale University; Giovanni Destro-Bisol, University "La Sapienza," Rome, and Himla Soodyall and Trefor Jenkins, WITS University, South Africa, looked at three locations on DNA samples from 13 to 18 populations in Africa and 30 to 45 populations in the remainder of the world.- New analysis provides fuller picture of human expansion from Africa - October 22, 2012 Excerpt: A new, comprehensive review of humans' anthropological and genetic records gives the most up-to-date story of the "Out of Africa" expansion that occurred about 45,000 to 60,000 years ago. This expansion, detailed by three Stanford geneticists, had a dramatic effect on human genetic diversity, which persists in present-day populations. As a small group of modern humans migrated out of Africa into Eurasia and the Americas, their genetic diversity was substantially reduced. per physorg
In fact, Blue eyes, light skin, Blond hair and lactase persistence, contrary to what Nazis thought, are the result of the loss of genetic information, not a gain:
Daily thought: blue eyes and other gene mutations, April 25, 2013 Excerpt: "Research on blue-eyes has led many scientist to further affirm that humans are truly mere variations of the same origin. About 8% of the world's total population has blue eyes so blue eyes are fairly rare. In fact, blue eyes are actually a gene mutation that scientist have researched and found to have happened when the OCA2 gene "turned off the ability to produce brown eyes." http://www.examiner.com/article/daily-thought-blue-eyes-and-other-gene-mutations Melanin Excerpt: The melanin in the skin is produced by melanocytes, which are found in the basal layer of the epidermis. Although, in general, human beings possess a similar concentration of melanocytes in their skin, the melanocytes in some individuals and ethnic groups more frequently or less frequently express the melanin-producing genes, thereby conferring a greater or lesser concentration of skin melanin. Some individual animals and humans have very little or no melanin synthesis in their bodies, a condition known as albinism. - per wikipedia Subtle change in DNA, protein levels determines blond or brunette tresses, study finds - June 1, 2014 Excerpt: The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor. This change affects how much KITLG is expressed in the hair follicles without changing how it's expressed in the rest of the body. Introducing the change into normally brown-haired laboratory mice yields an animal with a decidedly lighter coat -- not quite Norma Jeane to Marilyn Monroe, but significant nonetheless. http://www.sciencedaily.com/releases/2014/06/140601150924.htm Got milk? Research finds evidence of dairy farming 7,000 years ago in Sahara Excerpt: In premature babies, the gene coding for lactase is sometimes not yet active. And in much of the world’s population, the gene is downregulated after weaning, eventually producing some degree of lactose intolerance. Those whose genes are not downregulated are said to have “lactase persistence.” However, even lactose-intolerant people still have genes coding for lactase enzyme; they are just switched off. In an adult with lactase persistence, one or both alleles of the lactase gene remain switched on. http://www.answersingenesis.org/articles/2012/07/07/news-to-note-07072012 Critic ignores reality of Genetic Entropy - Dr John Sanford - 7 March 2013 Excerpt: Where are the beneficial mutations in man? It is very well documented that there are thousands of deleterious Mendelian mutations accumulating in the human gene pool, even though there is strong selection against such mutations. Yet such easily recognized deleterious mutations are just the tip of the iceberg. The vast majority of deleterious mutations will not display any clear phenotype at all. There is a very high rate of visible birth defects, all of which appear deleterious. Again, this is just the tip of the iceberg. Why are no beneficial birth anomalies being seen? This is not just a matter of identifying positive changes. If there are so many beneficial mutations happening in the human population, selection should very effectively amplify them. They should be popping up virtually everywhere. They should be much more common than genetic pathologies. Where are they? European adult lactose tolerance appears to be due to a broken lactase promoter [see Can’t drink milk? You’re ‘normal’! Ed.]. African resistance to malaria is due to a broken hemoglobin protein [see Sickle-cell disease. Also, immunity of an estimated 20% of western Europeans to HIV infection is due to a broken chemokine receptor—see CCR5-delta32: a very beneficial mutation. Ed.] Beneficials happen, but generally they are loss-of-function mutations, and even then they are very rare! http://creation.com/genetic-entropy
Moreover, contrary to what the Nazis believed about humans evolving into some sort of master race, the fact of the matter is that humans, all humans, are devolving instead of evolving:
If Modern Humans Are So Smart, Why Are Our Brains Shrinking? - January 20, 2011 Excerpt: John Hawks is in the middle of explaining his research on human evolution when he drops a bombshell. Running down a list of changes that have occurred in our skeleton and skull since the Stone Age, the University of Wisconsin anthropologist nonchalantly adds, “And it’s also clear the brain has been shrinking.” “Shrinking?” I ask. “I thought it was getting larger.” The whole ascent-of-man thing.,,, He rattles off some dismaying numbers: Over the past 20,000 years, the average volume of the human male brain has decreased from 1,500 cubic centimeters to 1,350 cc, losing a chunk the size of a tennis ball. The female brain has shrunk by about the same proportion. “I’d call that major downsizing in an evolutionary eyeblink,” he says. “This happened in China, Europe, Africa—everywhere we look.” http://discovermagazine.com/2010/sep/25-modern-humans-smart-why-brain-shrinking Scientists Discover Proof That Humanity Is Getting Dumber, Smaller And Weaker By Michael Snyder, on April 29th, 2014 Excerpt: An earlier study by Cambridge University found that mankind is shrinking in size significantly. Experts say humans are past their peak and that modern-day people are 10 percent smaller and shorter than their hunter-gatherer ancestors. And if that’s not depressing enough, our brains are also smaller. The findings reverse perceived wisdom that humans have grown taller and larger, a belief which has grown from data on more recent physical development. The decline, said scientists, has happened over the past 10,000 years. http://thetruthwins.com/archives/scientists-discover-proof-that-humanity-is-getting-dumber-smaller-and-weaker
The evidence for accumulating detrimental mutations in humans is overwhelming for scientists have already cited over 100,000 mutational disorders.
"Another compilation of gene lesions responsible for inherited diseases is the web-based Human Gene Mutation Database (HGMD). Recent versions of HGMD describe more than 75,000 different disease causing mutations identified to date in Homo-sapiens." John C. Avise - Inside the Human Genome: A Case for Non-Intelligent Design - Pg. 57
I went to the mutation database website cited by John Avise and found:
The Human Gene Mutation Database The Human Gene Mutation Database (HGMD®) represents an attempt to collate known (published) gene lesions responsible for human inherited disease. Mutation total (as of May 23, 2016) – 183,500
Again, The evidence for 'devolution', and/or adaptation by loss of genetic information is overwhelming. The only reason this is controversial is because it flies directly in the face of Darwinian presuppositions.bornagain77
June 20, 2016
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Bob O'H
I’m wondering what this probabalistic proof is that de novo gene can’t evolve.
How would you evolve my cell phone number with a random unguided process? How about a number that would contact 1 of my 50 friends on my direct dial. How would this change if phone numbers increased from 10 to 50 digits?bill cole
June 20, 2016
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Alicia posted, "the most unscientific community on the internet about….science." That is worthy of a heart felt ROTFLBorne
June 20, 2016
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Bob It is not the consensus that disagrees with ENCODE it's the dogmatistsAndre
June 20, 2016
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Bob Whatever works works..... hahahahahaha.... Darwinian evolution explains everything but really explains nothing....Andre
June 20, 2016
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I have to mention this. YEC's have stated for years that speciation is as a result of information loss. I think this paper vindcates them too.Andre
June 20, 2016
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PaV @ 22 - I see you don't rise to the challenge of asking whether gene duplication is more prevalent than gene loss. I'm wondering what this probabalistic proof is that de novo gene can't evolve. I also don't see ENCODE as a problem - the consensus is that they were being overly optimistic about function. I also don't see why pseudo-genes having a regulatory function is a problem: evolution is messy, and whatever works will work. Epigenetic is just (!) the mechanism by which the environment affects gene expression, but we knew is did already - "G by E" isn't controversial. So, you can declare victory. If anyone notices, they'll just shrug.Bob O'H
June 20, 2016
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So.. what's the argument here? At the moment it reads like 1. Gene loss can be adaptive 2 ... 3. also de novo genes are common and mutations are bad 4 .... 5 Victorywd400
June 20, 2016
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Seqenenre Hi There are pub med papers on di novo genes. The challenge for all the papers is identifying a mechanism that can account for their origin within reasonable population sizes and generations. According to Mychael Lynch's paper in 2010 it takes over 1 million generations and a population size of 10^11to fix an adaption requiring 5 specific mutations. So based on this how does a di novo gene arrive in a human that is not in a chimp that requires more then 5 specific mutations? This is a very real and unresolved problem for the theory of common decent. The genome is an organized sequence and sequences have almost unlimited possible ways of being organized. How they get organized into a gene coding sequence is quite a mystery.bill cole
June 20, 2016
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I used to love cartoons but then I grew up.RexTugwell
June 20, 2016
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@Rex Tugwell: Thanks for the non answer. Typical I have neither the time nor the patience for what probably amounts to a literature bluff from Alicia. Is anyone familiar with these “explanations” and what is your opinion.Seqenenre
June 20, 2016
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Many thanks, BA77. Now was that so hard, Alicia? @Seqenenre: Not so embarrassing when my suspicions are ultimately confirmed. Nice try though. Maybe you're willing to make a case for known mechanisms of de novo genes. Hmmm?RexTugwell
June 20, 2016
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Hahahahaha Dr Behe was right... again!Andre
June 20, 2016
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Alicia Cartelli, It took more typing and clicking to post that comment than to go to pubmed and search “de novo genes” Just another classic case of a creationist not wanting to learn. We just want to articulate using your words . How de novo genes are well understood . That's the insertion that you made . We don't feel that they are well understood , So it's not for us to make your case. So we just want you to back that up . Can you ?bmaque12
June 20, 2016
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RexTugwell: 25, 27 and 29 must be the most embarrassing 'triplet' of posts ever seen on the internet.Seqenenre
June 20, 2016
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Alicia Cartelli, since you are so concerned with being properly grounded in science, perhaps you would like to lay out the precise falsification criteria for Darwinian evolution so as to establish it as a testable hypothesis that is firmly grounded in science?
"In so far as a scientific statement speaks about reality, it must be falsifiable; and in so far as it is not falsifiable, it does not speak about reality." Karl Popper - The Two Fundamental Problems of the Theory of Knowledge (2014 edition), Routledge Dubitable Darwin? Why Some Smart, Nonreligious People Doubt the Theory of Evolution By John Horgan on July 6, 2010 Excerpt: Early in his career, the philosopher Karl Popper ,, called evolution via natural selection "almost a tautology" and "not a testable scientific theory but a metaphysical research program." Attacked for these criticisms, Popper took them back (in approx 1978). But when I interviewed him in 1992, he blurted out that he still found Darwin's theory dissatisfying. "One ought to look for alternatives!" Popper exclaimed, banging his kitchen table. http://blogs.scientificamerican.com/cross-check/dubitable-darwin-why-some-smart-nonreligious-people-doubt-the-theory-of-evolution/ It’s (Much) Easier to Falsify Intelligent Design than Darwinian Evolution – Michael Behe, PhD https://www.youtube.com/watch?v=_T1v_VLueGk Darwinian Evolution is a Unfalsifiable Pseudo-Science - Mathematics – video https://www.facebook.com/philip.cunningham.73/videos/vb.100000088262100/1132659110080354/?type=2&theater
bornagain77
June 20, 2016
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RexTugwell, The so-called 'explanation' for new genes from Darwinists is just the same ole hand-waving just-so story that Darwinists are notorious for whenever a finding contradicts their theory. (which is often)
Is the Origin of New Genes “Basically a Solved Problem”? - Cornelius Hunter - Sept. 11, 2014 Excerpt: If you read the headlines, you would have the impression that the problem is well in hand. For instance, super-star science writer Carl Zimmer wrote in the New York Times earlier this year that “researchers have documented the step-by-step process by which a new gene can come into existence.” Case closed right? Well not quite. In fact, not even close. What Zimmer tells his readers is a “step-by-step process” is what scientists affectionately refer to as a cartoon. In fact, here it is:,,, ,,,This evolutionary narrative is certainly not “basically a solved problem.” In fact, what evolutionists have are high claims of the spontaneous evolution of incredibly complex structures, not because of the evidence, but in spite of the evidence. So what gives evolutionist’s their confidence? It is not that they understand how such genes could have evolved, but that the genes must have evolved because solo genes are observed over and over: "Several studies have by now also shown that de novo emerged transcripts and proteins can assume a function within the organism. All of this provided solid evidence that de novo gene birth was indeed possible.",,, Does any of this mean that the de novo genes evolved from random mutations as the evolutionists claim? Of course not.,,, Only a few years ago they agreed that such evolution of new genes would be impossible. Now they have been forced to adopt it because the evidence unambiguously reveals solo genes, and evolutionists dogmatically insist that everything must have spontaneously evolved.,, http://darwins-god.blogspot.com/2014/09/is-origin-of-new-genes-basically-solved.html Could Chance Arrange the Code for (Just) One Gene? "our minds cannot grasp such an extremely small probability as that involved in the accidental arranging of even one gene (10^-236)." http://www.creationsafaris.com/epoi_c10.htm Can new genes arise from junk DNA? - August 2015 Excerpt: Researchers are beginning to understand that de novo genes seem to make up a significant part of the genome, yet scientists have little idea of how many there are or what they do. What’s more, mutations in these genes can trigger catastrophic failures. “It seems like these novel genes are often the most important ones,” said Erich Bornberg-Bauer, a bioinformatician at the University of Münster in Germany.,,, “How does novel gene become functional? How does it get incorporated into actual cellular processes?” McLysaght said. “To me, that’s the most important question at the moment.” https://uncommondescent.com/junk-dna/can-new-genes-arise-from-junk-dna/ Can new genes arise from junk DNA? - August 24, 2015 Excerpt: Scientists also want to understand how de novo genes get incorporated into the complex network of reactions that drive the cell, a particularly puzzling problem. It’s as if a bicycle spontaneously grew a new part and rapidly incorporated it into its machinery, even though the bike was working fine without it. “The question is fascinating but completely unknown,” Begun said. BA77: Moreover, the essential genes were somehow incorporated into the ‘bicycle’ while the bicycle was being peddled, i.e. while the cell was busy being alive. “How does novel gene become functional? How does it get incorporated into actual cellular processes?” McLysaght said. “To me, that’s the most important question at the moment.” https://uncommondescent.com/junk-dna/can-new-genes-arise-from-junk-dna/#comment-577484
bornagain77
June 20, 2016
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Right, instead of doing a simple literature search, you decide to ask the most unscientific community on the internet about....science. I would expect nothing less from UD.Alicia Cartelli
June 20, 2016
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I have neither the time nor the patience for what probably amounts to a literature bluff from Alicia. Is anyone familiar with these "explanations" and what is your opinion.RexTugwell
June 20, 2016
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It took more typing and clicking to post that comment than to go to pubmed and search "de novo genes" Just another classic case of a creationist not wanting to learn.Alicia Cartelli
June 20, 2016
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Thanks for the non answer. TypicalRexTugwell
June 20, 2016
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Just go onto pubmed and search "de novo genes" Do I need to walk you guys through everything?Alicia Cartelli
June 20, 2016
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"explanations we already have for de novo genes?" Care to share?RexTugwell
June 20, 2016
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Almost all mutations are deleterious? So humans all have identical genomes? How have scientists been altering the genome of organisms and cells for years without them all immediately dying? "de novo genes, which, probabilistically, cannot be explained" What about the explanations we already have for de novo genes? Are we ignoring those? Please, you think encode is going to find function in the entire genome? They won't even come close. And what happens when they find that some of these functions are important for evolution, and not necessarily the individual organism? Are you guys going to count those?Alicia Cartelli
June 20, 2016
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BTW, I left out the whole new area of transposons, which, as we know, have a non-random character.PaV
June 20, 2016
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Bob and Alicia: Almost all mutations are deleterious. When you compare species, you find de novo genes, which, probabilistically, cannot be explained, and is far beyond anything that gene duplication can explain. When you add to this the growing body of knowledge spawned by sequencing that tells us gene loss is a prevalent method of speciation, then little is left of Darwinian notions. When I say the war is over, I mean that Darwinism doesn't have a leg to stand on. But you can't tell that to Darwinists. So, it will probably take 20 years for this latest finding to sink in. But, watch out, because the ENCODE project still continues, and they have a plan for elucidating function throughout the genome. And then what? No junk-DNA; pseudogenes that have regulatory function; epigenetics demonstrating the tremendous dialougue between environment and genome. No, the war is over.PaV
June 20, 2016
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The main idea of the paper is that gene loss is an important evolutionary force, just as gene duplication, mutations, transposable elements, chromosome rearrangements, etc. all are. Period. There is no massive overthrow of evolutionary thought, as you would like to believe. Don't you think more of your friends would be jumping up and down and stomping their feet if it was? Sorry to burst your bubble.Alicia Cartelli
June 20, 2016
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The review is interesting (you can see it all via the naughtiness that is sci-hub), but it doesn't put deletion into context compared to other mechanisms of genomic evolution. So gene duplication (for example) could be much more important and prevalent. Declaring that the war is over because of this could be like saying that the Golden State Warrior are NBA champions because they scored 89 points in game 7.Bob O'H
June 20, 2016
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As long as they stay within lineages of a specific species, they are correct in their conclusion that gene loss was integral to adaptation to specific environments
No Positive Selection, No Darwin: A New Non-Darwinian Mechanism for the Origin of Adaptive Phenotypes - November 2011 Excerpt: Hughes now proposes a model he refers to as the plasticity-relaxation-mutation (PRM) model. PRM suggests that adaptive phenotypes arise as follows: (1) there exists a phenotypically plastic trait (i.e., one that changes with the environment, such as sweating in the summer heat); (2) the environment becomes constant, such that the trait assumes only one of its states for a lengthened period of time; and (3) during that time, deleterious mutations accumulate in the unused state of the trait, such that its genetic basis is subsequently lost. ,,, But if most adaptations result from the loss of genetic specifications, how did the traits initially arise? One letter (Chevin & Beckerman 2011) of response to Hughes noted that the PRM "does not explain why the ancestral state should be phenotypically plastic, or why this plasticity should be adaptive in the first place." http://www.evolutionnews.org/2011/11/no_positive_selection_no_darwi052941.html A. L. Hughes's New Non-Darwinian Mechanism of Adaption Was Discovered and Published in Detail by an ID Geneticist 25 Years Ago - Wolf-Ekkehard Lönnig - December 2011 Excerpt: The original species had a greater genetic potential to adapt to all possible environments. In the course of time this broad capacity for adaptation has been steadily reduced in the respective habitats by the accumulation of slightly deleterious alleles (as well as total losses of genetic functions redundant for a habitat), with the exception, of course, of that part which was necessary for coping with a species' particular environment....By mutative reduction of the genetic potential, modifications became "heritable". -- As strange as it may at first sound, however, this has nothing to do with the inheritance of acquired characteristics. For the characteristics were not acquired evolutionarily, but existed from the very beginning due to the greater adaptability. In many species only the genetic functions necessary for coping with the corresponding environment have been preserved from this adaptability potential. The "remainder" has been lost by mutations (accumulation of slightly disadvantageous alleles) -- in the formation of secondary species. http://www.evolutionnews.org/2011/12/a_l_hughess_new053881.html
IMHO, where they go off the rails in the study is where they try to extrapolate the loss of genetic information witnessed within lineages of a specific species to try to claim that gene loss was integral to macro-evolution between species. The large percentage of ORFan genes found in every new genome sequenced, by itself, refutes that notion.
Genes from nowhere: Orphans with a surprising story - 16 January 2013 - Helen Pilcher Excerpt: When biologists began sequencing genomes they discovered up to a third of genes in each species seemed to have no parents or family of any kind. Nevertheless, some of these "orphan genes" are high achievers (are just as essential as 'old' genes),,, But where do they come from? With no obvious ancestry, it was as if these genes appeared out of nowhere, but that couldn't be true. Everyone assumed that as we learned more, we would discover what had happened to their families. But we haven't-quite the opposite, in fact.,,, The upshot is that the chances of random mutations turning a bit of junk DNA into a new gene seem infinitesmally small. As the French biologist Francois Jacob wrote 35 years ago, "the probability that a functional protein would appear de novo by random association of amino acids is practically zero".,,, Orphan genes have since been found in every genome sequenced to date, from mosquito to man, roundworm to rat, and their numbers are still growing. http://ccsb.dfci.harvard.edu/web/export/sites/default/ccsb/publications/papers/2013/All_alone_-_Helen_Pilcher_New_Scientist_Jan_2013.pdf
Of related note to the 'rotting Y chromosome' hypothesis they alluded to:
Theory of the 'Rotting' Y Chromosome Dealt a Fatal Blow - February 2012 Excerpt: "the sequence of the rhesus Y, shows the chromosome hasn't lost a single ancestral gene in the past 25 million years. By comparison, the human Y has lost just one ancestral gene in that period, and that loss occurred in a segment that comprises just 3% of the entire chromosome", ",,,earlier work comparing the human and chimpanzee Ys revealed a stable human Y for at least six million years. "Now our empirical data fly in the face of the other theories out there. With no loss of genes on the rhesus Y and one gene lost on the human Y, it's clear the Y isn't going anywhere." http://www.sciencedaily.com/releases/2012/02/120222154359.htm Genes on the Y chromosome prove essential for male survival - April 23, 2014 Excerpt: Moreover, the vast majority of these tenacious genes appear to have little if any role in sex determination or sperm production.,,, "There are approximately a dozen genes conserved on the Y that are expressed in cells and tissue types throughout the body," he continues. "These are genes involved in decoding and interpreting the entirety of the genome. How pervasive their effects are is a question we throw open to the field, and it's one we can no longer ignore." Page believes this research will at last allow his lab to transition from proving the so-called rotting Y theorists wrong to a new era in Y chromosome biology.,,, http://www.sciencedaily.com/releases/2014/04/140423132421.htm
bornagain77
June 20, 2016
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