Special Issue on microRNAs – the smallest RNA regulators of gene expression
It is now well recognised that the majority of non-protein-coding genomic DNA is not “junk” but specifies a range of regulatory RNA molecules which finely tune protein expression. This issue of CDD contains an editorial and 5 reviews on a particular class of these regulatory RNAs, the microRNAs (miRs) of around 22 nucleotides, and which exert their effects by binding to consensus sites in the 3’UTRs of mRNAs. The reviews cover the role of miRs from their early association with CLL to other forms of cancer, their importance in the development of the epidermis and their potential as disease biomarkers as secreted in exosomes. In addition, we publish a News and Commentary on CRISPR, a technology which is not only revolutionising genetic manipulation in the lab, but which has the potential to treat genetic disease in vivo.
Oh? Does anyone remember when BioLogos founder Francis Collins was fronting “junk DNA”? So we were all suppose to rush to believe that. But hey, now we aren’t.