Doctor Ivette Lozano from Dallas, Texas on treating patients with HCQ Cocktails

_{kairosfocus

May 18, 2020

Defending our Civilization, Medicine, News Highlights, rhetoric, Sci-Tech watch

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Inimitable:

https://youtu.be/coyfWpwxedQ

Food for thought.

U/D: When it reaches the pharmacy . . .

U/D May 19, another Lozano interview:

And, oh yes, breaking 1: Mr Trump is praising — yes, I am NOT using, “touting” — a promising vaccination. Announcement by the firm, here.

Breaking, no 2, courtesy Daily Mail as usual:

Of course, the now standard, it’s risky is in the subheads.

U/D: Video:

Compare our Texas Doctor’s remarks. And then, there is the latest from Dr Raoult:

Whose report do you believe, why? END

Comments

F/N: Early Zn results, in a preprint:
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1 Abstract Background: COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Potential therapies and means of prophylaxis against COVID-19 are urgently needed to combat this novel infection. As a result of in vitro evidence suggesting zinc sulfate may be efficacious against COVID-19, our hospitals began using zinc sulfate as add-on therapy to hydroxychloroquine and azithromycin. We performed a retrospective observational study to compare hospital outcomes among patients who received hydroxychloroquine and azithromycin plus zinc versus hydroxychloroquine and azithromycin alone. Methods: Data was collected from electronic medical records for all patients being treated with admission dates ranging from March 2, 2020 through April 5, 2020. Initial clinical characteristics on presentation, medications given during the hospitalization, and hospital outcomes were recorded. Patients in the study were excluded if they were treated with other investigational medications. Results: The addition of zinc sulfate did not impact the length of hospitalization, duration of ventilation, or ICU duration. In univariate analyses, zinc sulfate increased the frequency of patients being discharged home, and decreased the need for ventilation, admission to the ICU, and mortality or transfer to hospice for patients who were never admitted to the ICU. After adjusting for the time at which zinc sulfate was added to our protocol, an increased frequency of being discharged home (OR 1.53, 95% CI 1.12-2.09) reduction in mortality or transfer to hospice remained significant (OR 0.449, 95% CI 0.271-0.744). Conclusion: This study provides the first in vivo evidence that zinc sulfate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19.
Worth noting. KFkairosfocus_{May 19, 2020
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Vivid, he has obviously been seriously misled regarding risks. KF PS: The exchange:
Cavuto: Dr. Janette Nesheiwat with us right now. Doctor, what do you think of this — surprised a lot of folks, the president wanted to take hydroxychloroquine, the White House physician or physician team let him, as a preventative measure I guess, to ward off COVID-19. Do you agree with hydroxychloroquine for that use? Dr. Nesheiwat: Hi, Neil. So it’s important to understand, first and foremost, this is an FDA-approved drug. It is not new, it’s been around for many years, and he is taking it as a prophylactic, preventative measure, which I think is very smart to do, because, you know, there’s a lot of people, we just saw recently the vice president’s press secretary tested positive. And you never know, with people coming and going, even if you test daily, you could pick it up, you know, that evening, and then potentially spread it, you know, the next day or two. [--> key context] Cavuto: Would you recommend it, doctor? Doctor, Would you recommend it? Would you recommend it, someone who, a patient came to you, “Doctor, I just heard the President of the United States is taking this as a preventative measure for COVID-19, I want to do it, too. Would you write a prescription for that patient to do just that? Dr. Nesheiwat: Neil, being a doctor on the front lines of this pandemic here in New York City, I have prescribed hydroxychloroquine to some of my patients. And for some of them, they said it helped tremendously. Some of them, it didn’t make much of a change. But each person needs to be looked at individually — Cavuto: For COVID-19? COVID-19, to deal with it — not for malaria, lupus, but for COVID-19 — you were fine with that? Dr. Nesheiwat: Yes, absolutely. For COVID-19. I have prescribed it to patients who were very, very ill. Some of them benefited from it. Some of them did not. So we need to look at each patient individually. You have to talk to your doctor. We have to look and see, do you have any underlying medical problems? Do you have post-follow-up? Will this medicine interact with any other medicines you may be on? So we have to look at the situation individually — Cavuto: Well, I just had a doctor on — I just had a doctor on, just to be clear, and I want to make sure I’m sharing good advice with people at home — that if you had any respiratory issues, cardio-related issues, diabetes, or any — this is not the thing you want to be taking. Is — I had a prior physician on earlier, who was saying, under no circumstances would I allow that. What do you think? Dr. Nesheiwat: That’s not necessarily true. We have to look at the individual medical history, their past medical history. Now, if you have an underlying cardiac arrhythmia, we ned to be careful. We might not want to put you on that unless, you know, you’re on your deathbed and it’s the last resort. But again, what’s important is that you look at the patient’s history, their underlying status, what medicines are they on, do they have any underlying medical problems. This is not a medication for everyone. But it’s important to have that conversation with your doctor to decide: is it best for you? Are you in a high-risk category of death from coronavirus — or, maybe you’re better off just taking high-dose zinc and vitamin D, for example. Both have been show to help fight coronavirus and help prevent viral replication. Cavuto: Got it. So if you’re in any of that high-risk group, if you’re in any of that high-risk group — very quickly, doctor — that might have any of these other issues, because there are many right now who might, and are hearing the president say that i’s a good thing to do — are you saying that, that group, the one thing you could lose is your life. You’ve got to be very careful, or not? Dr. Nesheiwat: It’s something that you can consider — again, you’ve got to have to have the discussion with your doctor to decide if it is best for you. It’s not going to be good for everyone. But it may be beneficial, and potentially life-saving for others. So think it is good to have this medication in our toolbox, along with remdesivir, while we wait for vaccines to become approved, and for other therapeutics to get on the market. Cavuto: All right, doctor. All right, we will have more after this. Dr. Nesheiwat, thank you very much.
PPS: It clips earlier remarks: >>Earlier in the program, Cavuto spoke with Dr. Robert Lahita, a prominent physican in New York, who said that while “we use it in those who are very sick,” he had seen “no effect whatsoever.”>> --> By then, it is onward complications that may well be doing the final damage: too late to do any good vs a stitch in time saves nine. I have seen reports that by that time, viruses may actually be absent. The VA tests were seriously flawed in this regard and were reported in misleading ways.kairosfocus_{May 19, 2020
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F/N:Notice the Raoult numbers as they keep on mounting up; 0.52% vs 3.13% fatalities. 80 - 90% reduction in deaths relative to the de facto standard, seems plausible. KF PS: While I have serious questions on ethics of placebo studies in this context [time, exposure to danger etc], the very fact that HCQ cocktails are being brought to such tests says something. I think we need to rethink the gold standard approach, given the general nature of inductive reasoning, patterns of evidence that are already available and the issues tied to first do no harm.kairosfocus_{May 19, 2020
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“If you are in a risky population here, and you are taking this as a preventative treatment to ward off the virus, or in a worse-case scenario you are dealing with the virus and you are in this vulnerable population, it will kill you,” the “Your World with Neil Cavuto” host said. “ I like Cavuto but what evidence does he have for this statement when prescribed under a Drs care? What does he mean by “ risky population” Vividvividbleau_{May 18, 2020
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Then there is this https://www.breitbart.com/the-media/2020/05/18/neil-cavuto-shocked-by-doctor-who-calls-hydroxychloroquine-potentially-life-saving/ Vividvividbleau_{May 18, 2020
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A clinical trial has begun to evaluate whether the malaria drug hydroxychloroquine, given together with the antibiotic azithromycin, can prevent hospitalization and death from coronavirus disease 2019 (COVID-19). The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is sponsoring the trial, which is being conducted by the NIAID-funded AIDS Clinical Trials Group (ACTG). Teva Pharmaceuticals is donating medications for the study. The Phase 2b trial will enroll approximately 2,000 adults at participating ACTG sites(link is external) across the United States. Study participants must have confirmed infection with SARS-CoV-2, the virus that causes COVID-19, and be experiencing fever, cough and/or shortness of breath. The investigators anticipate that many of those enrolled will be 60 years of age or older or have a comorbidity associated with developing serious complications from COVID-19, such as cardiovascular disease or diabetes. Participants will be randomly assigned to receive short-term treatment with either hydroxychloroquine and azithromycin or matching placebos. People living with HIV and pregnant and breastfeeding women also are eligible to participate in the study. The first participant enrolled today in San Diego, California. https://www.nih.gov/news-events/news-releases/nih-begins-clinical-trial-hydroxychloroquine-azithromycin-treat-covid-19 Why won’t the French doctors do the same clinical trial? There is no good reason not to.rhampton7_{May 18, 2020
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Fox News's Neil Cavuto warned that people must be careful with hydroxychloroquine. “The fact of the matter is though, when the president said 'what have you got to lose?', in a number of studies, those certain vulnerable population has one thing to lose: their lives," Cavuto said. "If you are in a risky population here, and you are taking this as a preventative treatment to ward off the virus, or in a worse-case scenario you are dealing with the virus and you are in this vulnerable population, it will kill you," the "Your World with Neil Cavuto" host said. “I cannot stress enough. This will kill you. So, again, whatever benefits the president says this has, and certainly it has had for those suffering from malaria, dealing with lupus, this is a leap that should not be taken casually by those watching from home or assuming, well the president of the United States says it's OK," he said. Cavuto said he was not seeking to get involved in a political debate with his own comments. "I only make this not to make a political point here but a life and death point. Be very, very careful," he said. https://thehill.com/homenews/media/498400-fox-news-cavuto-warns-hydroxychloroquine-will-kill-you-after-trump-announces?amprhampton7_{May 18, 2020
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Fox News Channel senior managing editor for health news Dr. Manny Alvarez said Monday that President Trump was being "highly irresponsible" for taking the antimalarial drug hydroxychloroquine as a preventive against contracting coronavirus. "I found it to be highly irresponsible for the president to have come out and make that statement," Alvarez told "Special Report with Bret Baier." "And I would like to hear from the White House physician, to come out tomorrow and explain to me what has changed in a week and a half or two weeks for the president to take this medication when all the data that has been coming out, you know, very repetitively has shown that there's really not a major benefit in most hospitals, including mine." Alvarez explained there are currently no case review studies showing the drug to be "effective" and warned about side effects. https://www.foxnews.com/media/dr-manny-trump-highly-irresponsible-hydroxychloroquine-coronavirusrhampton7_{May 18, 2020
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complaining on Mr Trump giving a rough NY Contractor layman rendering on F-35 stealth technology is irrelevant to several troubling concerns being put on the table
If there was a legitimate objection, it would be put on the table for evaluation. Those who argue against HCQ especially with zinc are an example of the "dog barking in the night." They are literally not barking because there is nothing to bark at. Thus, irrelevant diversion is the best they can offer. Each attempt is actually an endorsement of the treatment so we should thank those who do it. I am waiting for the "there is no RCT" objection. The Brazilian doctor's reference list linked to above includes use of HCQ for viral infections that date to the 1980's,jerry_{May 18, 2020
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Seversky, I suggest you listen to the full statement of the Doctor (who dates back to the early HIV days) and to her summary of her experiences with her patients. She explicitly stands on her own informed judgement as a physician and summarises significant initial relief in ~ 5 hrs, getting major symptoms under control in 24 - 48 hrs and more. She points to a fear factor that apparently amplifies suffering. Patients are being sent home by facilities with little treatment, are told isolate. and as a result she is seeing families with multiple patients. There is a further issue of pharmacies being given instructions to demand diagnoses and resisting issuing prescriptions. Distractive cross-complaining on Mr Trump giving a rough NY Contractor layman rendering on F-35 stealth technology is irrelevant to several troubling concerns being put on the table. Meanwhile, the Raoult numbers keep on marching on the same line. KFkairosfocus_{May 18, 2020
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Then there is this Cedar Sinai Dr Daniel Wallace author of over 400 peer review papers wrote “ HCQ is very safe drug, in over 42 years of practice no patient of his has ever been hospitalized for HCQ complication” I don’t know if HCQ is effective against Covid but to say it’s an unsafe drug when prescribed under a Drs care is ludicrous. Vividvividbleau_{May 18, 2020
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Anyone who relies on Donald Trump for medical advice or any kind of technical advice is playing Russian roulette with their health. This is the man who boasted to US Coast Guard pilots that the F-35 fighter was equipped with something like a Romulan cloaking-device that makes the aircraft completely invisible in flight. He simply doesn't care about whether what he says is true or false. All he's concerned about is whether it makes the right impression on his audience at any given moment. And you are going to take his word on anything? Good luck with that. As for self-proclaimed pro-Trump activist, Dr Lozano, taking to the streets with a loud-hailer is not how you do science or medicine, although it's a good political stunt.Seversky_{May 18, 2020
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Fun stuff, u/d, what happened when prescriptions reach the pharmacy.kairosfocus_{May 18, 2020
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I saved this vid, too. My guess is, gone in 24 - 48 hours.kairosfocus_{May 18, 2020
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Several of Zelenko's videos have been taken down. It is called violating community guidelines. My guess is that the community guidelines are letting people die from ignorance. I have already made a copy of this video in. case it gets taken down. I wish I had done that with the other Zelenko videos. I do have a few though. Brazilian infectious disease doctor has posted a list of successful studies using HCQ. https://bit.ly/2ZfQAGX and https://bit.ly/3cVsw0d Some go back to the 1980's In France where the rate of death is very high, it is very low in Marseille which uses Raoult formula. https://bit.ly/36aei93 (may be in French but here is key passage in English)
When we now look at the treatments used and here the data are at the level of the city of Marseille. The mortality rate, all positive people, all hospitals combined, is 3.1%. This rate rises to 8.6% for people who have not received the HCQ and AZ treatment. What is interesting to note is that this rate is 0.5% for patients who have received HCQ and AZ treatment.
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Anybody making bets as to how long before this video is suppressed by YouTube/Google?kairosfocus_{May 18, 2020
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Doctor Ivette Lozano from Dallas, Texas on treating patients with HCQ Cocktails -- also, Mr Trump praises a promising vaccination and reveals he is on the HCQ cocktail. With Dr Raoult's latest numbers. Whose report do you believe, why?kairosfocus_{May 18, 2020
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