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Dr Raoult in his own voice on HCQ, with English sub-titles

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Jerry has again hit gold, and so here is Dr Didier Raoult, in his own voice, with English sub-titles:

https://youtu.be/Xhoi1JKjClk

Let us view and discuss. U/D: it will be helpful to take time to follow this video also, where others have a say.

(As time permits, I will put up some screen captures as updates below.)

Let us view and let us think together. END

F/N: Let me stack screen shots, first, who and what we are dealing with:

Next, the study:

Note, for reference, its approval:

Research protocol approved by the ANSM [= “Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM)”, i.e. National Agency for the Safety of Medicines and Health Products] and the Île-de-France CPP [= “COMITE DE PROTECTION DES PERSONNES ILE DE FRANCE,” i.e. ILE DE FRANCE PERSONAL PROTECTION COMMITTEE] in progress at the IHU Méditerranée Infection: Treatment of respiratory infections with Coronavirus SARS-Cov2 by hydroxychloroquine Acronym: SARS-CoV2quine.”

Treatments:

Let’s update from earlier today:

In short, this is a growing work in progress.

Next, his evaluation on mortality rate:

And so:

Comments
Which, will take several months to over a year depending. Similar to the hoped for vaccination.kairosfocus
April 24, 2020
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If zinc is an effective treatment, trials should show it. If it’s a miracle cure, this should be spotted quickly.
You actually followed a link but as usual provided a nitpick. It already has a response and it is nearly 100% cure. Apparently you are not following the links provided here. The control is no treatment with thousands of deaths which is the current method of treatment. At last look there are over 60 doctors who have signed on to a treatment that seems to work in nearly all cases. I have seen no logical argument against its use other than we have to wait for a controlled study.jerry
April 24, 2020
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BO'H, pardon but you overlook the recent Raoult study of in vitro effects released at the same time as his 80 patient study that led to a response by the French authorities and was shortly followed by stage 2 emergency approvals by FDA. It was announced here at UD within a few days of the release. That study specifically focussed on plausible in tissue concentrations. Your wording also leaves a dismissive impression when in fact work with animal physiological analogues has long been a major investigatory technique. So, from 15 years ago, we have documented broad based chemical action against RNA and DNA viruses, bacteria and yeasts. We have more recent in vitro work pointing to effectiveness against SARS2. We know HCQ is an effective drug, making a ready transition from the gut to the bloodstream and body. We know it works as an anti inflammatory [relevant to out of control inflammatory response]. We have reasonable management procedures for side effects and dosages.We have thousands of cases showing significant action, by contrast with the de facto baseline treatments. Yes, there are objections and there are headlined seemingly contrary studies, but these seem to come from late stage interventions. In short, there is reason to see this as a reasonable candidate, given epidemic situation and the time a vaccine and other trials approaches will take . . . not even counting epistemological, logical and ethical concerns. KFkairosfocus
April 24, 2020
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Jerry @ 61 - ah, thanks for that link. It show activity in a culture of cells from a monkey, which is a long way from showing that it will work to help patients. There is no guarantee that infected cells in patients will receive a high enough concentration of zinc, or if they do that other cells won't receive too much zinc. It's well established in drug development that most drugs that work in the lab aren't effective in practice (that's why the process of drug development is so slow, because their effect has to be checked). If zinc is an effective treatment, trials should show it. If it's a miracle cure, this should be spotted quickly.Bob O'H
April 24, 2020
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Jerry
Combination of hydroxychloroquine plus azithromycin as potential treatment for COVID 19 patients: pharmacology, safety profile, drug interactions and management of toxicity. - April 22, 2020 Guillaume Hache, Jean Marc Rolain, Philippe Gautret, JeanClaude Deharo, Philippe Brouqui, Didier Raoult, Stéphane Honoré CONCLUSION According to these data, the combination of hydroxychloroquine and azithromycin appears to have a theoretical safe profile with few clinically relevant drug-drug interactions. The main side-effects related to hydroxychloroquine are gastrointestinal symptoms and mainly nausea, vomiting and diarrhea. The main risk of the drug combination remains the risk of cardiac toxicity which can be prevented by respecting the contraindications of each drug and monitoring through systematic electrocardiogram and ionogram during the association. Our current observations and practices illustrate the efficacy of risk management. Data about safety of alternative dose regimen of this protocol, ongoing in clinical trials with COVID-19 patients are needed. https://www.mediterranee-infection.com/hydroxychloroquine-azithromycin-and-covid-19response-to-magagnoli-medrxiv-2020-2/
bornagain77
April 24, 2020
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There was no treatment for this disease other than to ameliorate the symptoms of the patient and hope the immune system will defeat it.
This point should be emphasized again and again. People were dying by the thousands without a way to treat them than hoping their immune system would overcome the virus. Then someone comes along and says we have a treatment that seems to work based on some past research. Let's try it. And it apparently did work. And what do we get but massive resistance to trying something that seems to work. Why? Why do a large percentage of the population object to a harmless treatment that seems to work based on some past research and very positive current results? And it is incredibly inexpensive. Unbelievable cynicism is the only explanation. I am sure some of the nitpickers will pick up on my used of the word "harmless" but this is in fact what has been found by using this treatment on C19 patients.jerry
April 24, 2020
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this discussion has gone over several threads, so it would take me long time to go through them to find the relevant links.
Maybe you should not comment then if you do not try to understand the arguments. Zinc first appeared here as a way to eliminate the virus about a month ago and has been mentioned hundreds of times since. I first found the discussion of zinc on an Austrian medical site (medmastery) when someone on my twitter thread said this site undermined HCQ as a valid drug for the C19 virus. The same site then extolled the value of zinc in conjunction with HCQ. Then I found the same discussion on a US medical site (MedCram aimed at doctors and medical professionals) and then here. I rarely come here anymore and popped in and found a discussion on the virus with good information especially with the Zelenko discussion. I was unaware of it but combined it with my other sources to try to understand what it is all about. So I feel I can comment mainly with backing by medical sources. And by my understanding of human behavior. Here is the main reference to zinc and HCQ working in tandem. HCQ seems to have other benefits besides being an ionophore. That was provided in other places.
Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. https://www.ncbi.nlm.nih.gov/pubmed/21079686
There was no treatment for this disease other than to ameliorate the symptoms of the patient and hope the immune system will defeat it. So any controlled study will take a lot of time as it is compared to doing nothing but making the patient comfortable. Thousands have died under this strategy.jerry
April 24, 2020
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Start with this paper, Bob O'H: Effect of Zinc Salts on Respiratory Syncytial Virus Replication Then use google to find moar!!!ET
April 24, 2020
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What science says this?
Clinical trials? No clinical trials.
OK, so science can't say that it has a therapeutic effect. At least not in humans. Rats, maybe. Or cells in Petri dishes.
You have been exposed to the links discussing it which indicates you are not following the information flow.
True, and my apologies for that. But this discussion has gone over several threads, so it would take me long time to go through them to find the relevant links. I was hoping you'd be kind enough to help.Bob O'H
April 24, 2020
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What science says this? Clinical trials?
No clinical trials. I doubt they would expend the money on a drug that cost literally pennies per dose. The zinc supplement at the Zelenko dosage cost 7 cents per day for 5 days. Given the current nightmare there are some planned. Meanwhile tens of thousands have died and not told of a solution that cost 35 cents. There was a study showing HCQ is an ionosphere for zinc and it stopped a previous version of coronavirus. You have been exposed to the links discussing it which indicates you are not following the information flow.jerry
April 24, 2020
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Well, Bob O’H, the science says that zinc plus an ionophore, like HC, will prevent the virus from replicating.
Wat science says this? Clinical trials? Can you give a link to it?Bob O'H
April 24, 2020
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Jerry, 27:
I’m not as interested in the evolution debate because the evidence is so overwhelming in one direction. Note the irony of using that term because that is the word Darwinist constantly used without providing any evidence.
What tipped the balance for me was when it truly registered that DNA is alphanumeric, algorithmic code in the literal heart of the cell. As in, language applied to goal-directed, finite, stepwise halting process requiring a cluster of molecular nanotech execution machinery. This has been on the table literally since Crick's March 19, 1953 letter to his son, which sold some years ago for US$ 6 mn. Language so applied is absolutely decisive, period. So, the onward issue is fundamentally epistemological: what explains the institutionalised selective hyperskepticism that has led to blindness to the significance of findings that won several Nobel prizes. So, they cannot be seen as things done in a corner. A key clue comes from Monod, as I discussed here at UD. There, we find the smoking gun, from the mouth of one of the Nobel Prize winners. Then, as we turn to the current issue, lo and behold, the same underlying pattern is showing up, with lives on the line. KFkairosfocus
April 23, 2020
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Zinc is great
It seems that no matter how many times one posts a valid link or reason, it will be questioned by the same person at a later time or by another person who does not pay attention. Zinc has been a center of focus here since Zelenko appeared in an OP 4 weeks ago. One would have thought it might have. gotten through by now. I actually thought it was funny because my wife and I always joked about Zicam. Every time we took it our cold went away. Sometimes in a day, sometimes in 2 weeks.jerry
April 23, 2020
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Zinc is great at killing bacteria, too. You just have to do it with moderation. It's also great for curing acne. 30-45mg/ day. But if you are sick with the flu or covid 19, then you up the dose for up to two weeks.ET
April 23, 2020
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Well, Bob O'H, the science says that zinc plus an ionophore, like HC, will prevent the virus from replicating. The youtube video cites peer-reviewed work on zinc and viruses. So any doctor who knows that and goes with HC alone, shouldn't be allowed near patients. Any doctor that doesn't know that is ignorant and shouldn't be allowed to teat patients.ET
April 23, 2020
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EVMS CRITICAL CARE COVID-19 MANAGEMENT PROTOCOL:
• Vitamin C 500 mg BID • Zinc 75-100 mg/day (acetate, gluconate or picolinate; do not use for more than 2 months) • Quercetin 500-1000 mg/day • Melatonin (slow release): Begin with 0.3mg and increase as tolerated to 1-2 mg at night • Vitamin D3 1000-4000 u/day (optimal dose unknown; likely that those with baseline low 25-OH vitamin D and those > 40o latitude will benefit the most)
ET
April 23, 2020
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Sev, have you been noticing how I have been pointing to an old pharmaco prof's opening for his pharmacology course? The opening that shocked 1st year, bright-eyed, bushy tailed med students: pharmacology is the study of poisons in small doses. Yes, there is a Goldilocks zone for Zn, as for water, salt, sugars, you name it. When you got hit with an RNA virus, the overall needs of your body shift for long enough to suppress the invasion until the immune system can kick in without blowing up into a cytokine storm. In that window, Zn plus an ionophore can make a key difference. And it helps that the drug is going to be rapidly excreted so things will go back quickly. KFkairosfocus
April 23, 2020
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@48 Seversky
Simply pumping more zinc into the body willy-nilly may do more harm than good.
Speaking of charlatanery. More means nothing scientifically speaking. More in science depends on the context. That's why studies are needed. Those that darwinists love so much although paradoxically we can not trust our monkey minds.Truthfreedom
April 23, 2020
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Simply pumping more zinc into the body willy-nilly may do more harm than good.
Tell that to the medical sites that are recommending and to the several hundred patients receiving it with good results.jerry
April 23, 2020
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A simple search on zinc metabolism will find that, like other nutrients, too little zinc can cause deficiency symptoms but too much can be toxic,. The body already has good zinc transport mechanisms for getting the required amount into the cells. Increasing the amount of zinc may have antiviral effects but we need to know how much, if any. Simply pumping more zinc into the body willy-nilly may do more harm than good. This is one of the reasons we need why we need properly-conducted trials. Regardless of any hyperbole about "gold standard", they are what stand between us and the rampant charlatanry and fraud of past centuries.Seversky
April 23, 2020
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BO'H, you know there is a web site with much more data. What the OP does is it allows us to actually hear the man in his own voice. Something, that is desperately needed given the hysteria. And that's part of why I just put up UWI's teleconference. KFkairosfocus
April 23, 2020
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kf - do you have something more rigorous than a youtube video?Bob O'H
April 23, 2020
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PS: From the new Brazilian study, background: >>The [SARS2] infection early stage is characterized mainly by respiratory symptoms, including fever, cough, sore throat and fatigue (4). Later, high viral replication, high inflammatory activity and exacerbated immune response leads to a “cytokine storm”, which is responsible for complications, such as severe pneumonia and acute respiratory distress syndrome (5), with increased requirement of ventilatory support and intensive care unit (ICU) admission (1, 6) --> See Science article: https://www.sciencemag.org/news/2020/04/how-does-coronavirus-kill-clinicians-trace-ferocious-rampage-through-body-brain-toes ] . . . . Chloroquine was first synthesized in Germany in 1934 and has been used for decades as first-line drug in the treatment and prophylaxis of malaria. Previews in vitro studies had reported that chloroquine has antiviral activity against several RNA- viruses, such as rabies (9), poliovirus (10), Hepatitis A and C viruses (11, 12), Influenza A and B (13, 14), Dengue (15), Zika (16) and recently also against coronavirus (17). [--> in literature, it also affects DNA viruses, some bacteria, yeast etc; this suggests, effects against core cellular mechanisms] Mechanism of action includes blocking cell infection by increasing the endosomal pH and interfering with the glycosylation of the SARS-CoV2 cell receptor (18, 19). [--> the Zn effect of helping to admit Zn is also raised, several mechanisms may be working jointly, an advantage as it likely makes a resistance mutation probabilistically harder to find] According to Chinese reports, approximately 100 patients infected and treated with chloroquine had a faster decline in fever, improved images of pulmonary tomography (CT), with shorter recovery time, and no serious adverse effects were observed (20). Hydroxychloroquine, a derivative of chloroquine, has a hydroxyl group at the end of the side chain, having pharmacokinetics similar to chloroquine, with rapid gastrointestinal absorption and renal excretion [--> comes in fast, circulates in blood, goes out fast, reducing build-up effects, so does something you want drugs to do: get into the body, do its job, get out], in addition to a less toxic profile (21). Hydroxychloroquine also has been demonstrated to inhibit SARS-CoV-2 infection in vitro (22). [--> specific antiviral action, with something likely to get into tissues fast through the gut and blood stream, then go out through kidneys] Moreover, Gautret et al (23) in an open-label non-randomized clinical trial with a small sample size have reported that hydroxychloroquine significantly reduced viral carriage on day 6 post-treatment compared to control group. [--> early Raoult work, now supported by later work. Note, as there is a natural baseline of typical treatments, we can identify differential effects] Furthermore, adding azithromycin to hydroxychloroquine increased treatment’s effectiveness. [--> synergy] A randomized study from China also found that patients treated with hydroxychloroquine compared to control improved lung imaging findings and had shorter time to clinical recovery (24). [--> preventing needing a ventilator] The antiviral and anti-inflammatory activities of chloroquine/hydroxychloroquine may be responsible for its efficacy in COVID-19 treatment (19, 25). [--> may . . . ] Moreover they are well-studied drugs with limited toxicity (26) and generally mild and transient side effects (27). The use of chloroquine for more than 70 years as an antimalarial treatment reinforces its safety for acute administration. Long prescription of hydroxychloroquine for rheumatic disease also has demonstrated the low incidence of adverse events for periods up to five years (26). [--> low likelihood of unexpected damaging effects] Furthermore, hydroxychloroquine’s low cost makes it a feasible option for massive scale use. >> Perhaps, this will help rebalance. KFkairosfocus
April 23, 2020
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there is a new Brazil study
I have seen it and was going to post it but you beat me to it.jerry
April 23, 2020
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Jerry, there is a new Brazil study on the table, please scroll up to 32. KFkairosfocus
April 23, 2020
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HEALTH AND SCIENCE Trump says he ‘totally disagrees’ with Georgia Gov. Kemp’s decision to reopen businesses in the middle of coronavirus pandemic https://www.cnbc.com/2020/04/22/trump-says-he-totally-disagrees-with-georgia-gov-kemps-decision-to-reopen-businesses-in-the-middle-of-coronavirus-pandemic.htmlJim Thibodeau
April 23, 2020
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BO'H: Zn plus pathways into cells does work, as the medcram video speaks of. KFkairosfocus
April 23, 2020
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RH7, please read what has come up already. First, the trials are real, and produced real results consistent with the chemical and somatic activity of the relevant compounds; the gold standard fallacy is just that, fallacious. Next, if you are in hospital headed for ventilator use, the disease is far advanced in damage already done to lungs; the point as the Brazil study shows, is to prevent getting to that hard to reverse state. Have you listened to Dr Zelenko, you don't sound like it. I think we need to go back to first principles, e.g. there is no magic in the BIO in biochemistry. Immediately as a compound known to get into tissues in measurable concentration acts on cells in relevant ways at such concentrations, there is a potential for drug action. That has been tested in this case and results consistent with that expectation are back. Where, the point for using the cocktail with supplements is to PREVENT the sort of damage that is there once one needs to be hospitalised. At that point, you are already at second or third best options. KFkairosfocus
April 23, 2020
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don’t you think it’s possible that they do know bout zinc, but in their estimation, they don’t think it’ll be effective?
Do you know this? It has appeared on three well respected medical sites highlighting that it essentially prevents the virus from replicating. There was the case of a doctor in Texas who was prime for dying and contracted C19 and took the Zelenko medicine and then recovered in a few days but said he wouldn't recommend it to others. Because he felt really bad for a couple days. Apparently being alive is not a good result when feeling crappy for a couple days is necessary to achieve it. Dr. Zelenko said he has received same reaction from some of his patients who called and say treatment was not working. Zelenko's response was I am glad you are still alive. He has nearly 100% success. There is a medical movement to report all results of HCQ and the use of zinc. So far no negatives when used appropriately. But what do you get from the press: the fish tank episode, the VA hospital fake news study, the Brazilian study that tripled the dosage.jerry
April 23, 2020
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More misleading news from RHampton. He is getting to be a pretty reliable source for it.jerry
April 23, 2020
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