Retired prison psychiatrist Theodore Dalrymple must have heard it all. This from him on a popular example:
Among the propositions defended with such suspect ferocity is that men can change straightforwardly and unambiguously into women, and vice versa. Now everyone accepts that they can change into something different from ordinary men and women, and can live as if they were of the opposite of their birth sex; moreover, there is no reason to abuse or otherwise maltreat them if they do, and kindness and human decency require that we do not humiliate them or make their lives more difficult than they are. But this is not at all the same as claiming that those who take hormones and have operations actually are the sex that they choose, or that it is right to enshrine untruth in law and thereby force people to assent to what they know to be false. That way totalitarianism lies. – Law & Liberty, February 15, 2023
Unworkable or unbelievable science might be expected to take refuge in totalitarianism. That rids it of the risk of falsification.