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random mutation (and sickle cell disease)

Researchers: Genetic mutation against malaria is not random

Researcher: “I do not think it is a coincidence that the HbS mutation, which provides protection against malaria, originates de novo more frequently in sub-Saharan Africans than in Europeans,” Livnat says. “I also do not think it is a coincidence that it originates more frequently in the gene where it provides this protection compared to the nearly identical nearby delta globin gene, where precisely the same mutation could happen but would not provide protection.” Read More ›