CTCF controls ~ 10,000 3D Chromatin Loops
Erez Aiden’s team of Baylor researchers discover a CTCF protein controlling 3D formation of 10,000 loops. Only 1 of 4 orientations is found. Challenges for evolution:
1) How did this essential CTCF protein develop to loop DNA when the DNA is essential for its production.
2) How was the 1 orientation in 4 selected?
See: There’s a Mystery Machine That Sculpts the Human Genome Read More ›