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Gambler’s ruin is Darwin’s ruin

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The same day I first watched “Expelled” in theaters, I also watched the movie “21”. The movie “21” is based on the true story of MIT students who made a fortune in Las Vegas casinos through the use of mathematics.

The real story behind the movie began with an associate of Claude Shannon by the name of Dr. Edward O. Thorp of MIT. In the Early 60’s, Thorp published a landmark mathematical treatise on how to beat casinos. His research was so successful that Las Vegas casinos shut down many of their card tables for an entire year until they could devise counter measures to impede Thorp’s mathematics.

Thorp is arguably the greatest gambler of all time. He extended his gambling science to the stock market and made a fortune. His net worth is in the fractional to low billions. He is credited with some independent discoveries which were the foundation to the Black-Scholes-Merton equation relating heat transfer thermodynamics to stock option pricing. The equation won the Nobel prize and was the subject of the documentary: The Trillion Dollar Bet.

Thorp would probably be even richer today if Rudy Gulliani had not falsely implicated him in the racketeering scandal involving Michael Milken. Thorp, by the way, keeps a dartboard with Gulliani’s picture on it… 🙂

The relevance of Thorp’s math to Darwinism is that Thorp was a pioneer of risk management (which he used to create the world’s first hedge fund). In managing a hedge fund or managing the wagers in casinos, one is confronted with the mathematically defined problem of Gambler’s Ruin. The science of risk management allows a risk manager or a skilled gambler to defend against the perils gamblers ruin. Unfortunately for Darwinism, natural selection has little defense against the perils of gambler’s ruin.

Even if an individual has a statistical advantage over a casino game, it is possible the individual can lose. Let’s say a skilled player has a 1% advantage on average over the casino. He wanders into the casino, looks for a favorable opportunity and wagers $500,000.00.

If he has a 1% statistical advantage, that means he has a 50.5% chance of winning and a 49.5% chance of losing. Even though he has a slight edge, he still has a very substantial chance of losing. It would be unwise to bet $500,000.00 if that is his life savings!

The movie “21” romanticized the advantage skilled players have. The movie “21” portrayed the MIT students as people who could sit at card tables and bilk casinos like ATM machines. That’s not how it works as testified by one of the more noteworthy members of the real MIT team by the name of Andy Bloch. Bloch reported that during his tenure as manager of the MIT team, the team was once in the red for 9 months before recovering. Skilled players lose big bets not quite 50% of the time. It is not unusual, on average, to have a losing streak of 8 hands in a row every 256 rounds. Ben Mezrich reported in his book, Bringing Down the House, an incident where the Big Player of the MIT team lost 3 hands in a row in 45 seconds of play for a sum total of $120,000.00! It happens…

A skilled player with a 1% advantage might expect to play 50,000 hands before his expected value exceeds the effect of one standard deviation of bad luck. That means he might have to play a looooong time before he realizes a profit….

What does this have to do with Darwinism? Darwin argued that

Natural selection acts only by taking advantage of slight successive variations; she can never take a great and sudden leap, but must advance by short and sure, though slow steps.”

But that is complete nonsense mathematically speaking because of the problem of gambler’s ruin. It is not surprising that Darwin could not see the flaw in his argument because he could not even do high school algebra even after substantial effort. The lack of basic math and logic pervades his flawed theory.

The problem is that a selectively-advantaged traits are still subject to random events. The most basic random event is with whether a parent will even pass down a gene to a child in the first place! Added to that problem is the nature of random events in general. A genetically advantaged individual may die by accident, get consumed by a predator, etc.

And the problem gets worse. Even if selectively advantage traits get spread to a small percentage of the population, it still has a strong chance of being wiped out by the sum total of random events. The mathematics of gambler’s ruin helped clarify the effect of random “selection” on natural selection.

Without going into details, I’ll quote the experts who investigated the issues. Consider the probability a selectively advantaged trait will survive in a population a mere 7 generations after it emerges:

if a mutant gene is selectively neutral the probability is 0.79 that it will be lost from the population
….
if the mutant gene has a selective advantage of 1%, the probability of loss during the fist seven generations is 0.78. As compared with the neutral mutant, this probability of extinction [with natural selection] is less by only .01 [compared to extinction by purely random events].
….

Theoretical Aspects of Population Genetics
Motoo Kimura and Tomoko Ohta

This means is that natural selection is only slightly better than random chance. Darwin was absolutely wrong to suggest that the emergence of a novel trait will be preserved in most cases. It will not! Except for extreme selection pressures (like antibiotic resistance, pesticide resistance, anti-malaria drug resistance), selection fails to make much of an impact.

The contrast between a skilled gambler and natural selection is that a skilled player can wager small fractions of the money he sets aside for his trade. If a skilled gambler has $50,000, he might wager $100 at a time until the law of large numbers causes his statistical advantage to be asserted. He can attempt many many trials until his advantage eventually prevails. In this manner a skilled gambler can protect himself against the mathematics of gamblers ruin.

But natural selection is a blind watchmaker. It does not know how to perform risk management like a skilled player or the great math wizard, Edward Thorp. For natural selection to succeed in the way Thorp succeeded in the great casinos of Nevada and Wall Street, it has to hope the same mutant appears spontaneously many many times in many individuals. But for complex genes, this doesn’t happen. Truly novel and beneficial mutations are rare. They don’t repeat themselves very often, and when they arise, they will likely be wiped out unless there is fairly intense selection pressure (like we see in pesticide resistance or anti-biotic resistance or anti-malaria drug resistance, or malaria resistance associated with sickle cell anemia).

A further constraint on selective advantage of a given trait is the problem of selection interference and dilution of selective advantage if numerous traits are involved. If one has a population of 1000 individuals and each has a unique, novel, selectively-advantaged trait that emerged via mutation, one can see this leads to an impasse –selection can’t possibly work in such a situation since all the individuals effectively cancel out each other’s selective advantage.

This illustrates that there has to be a limit to the number of innovations appearing in a population simultaneously for selection to work. The emergence of advantageous mutations in a population has the net effect of diluting the selective advantage of all the traits.

If trait A has a large selective advantage in relation to trait B, trait A dilutes the selective advantage of trait B. Thus trait B is exposed more and more to gambler’s ruin because of the existence of trait A. For example an individual with better eyesight (trait A) might prevail over an individual with higher intelligence (trait B). An otherwise good trait (intelligence) is lost because another trait (good eyesight) interferes with the ability of that trait (intelligence) to be maintained…

Thus one can see the problem of many “slight advantageous traits” being necessarily “slight” because of the problem of interference. But “slight” implies they are subject to gambler’s ruin, and thus unlikely to be preserved as Darwin asserted. Thus Darwin was dead wrong….

John Sanford gives a more rigorous treatment in his book Genetic Entropy where he gives more exact numbers on the limits of selective advantage based on problems such as interference. Sanford shows that a 1% selective advantage is fairly generous, and is usually less than 1%. [I emphasize the word “usually”].

Most ironic is that Fisher’s analysis of the effect of gambler’s ruin essentially trashes his own theorem, Fisher’s Fundamental Theorem of Natural Selection. Fisher’s Malthusian notions of “fitness” in his fundamental theorem do not account for the effect of random events taking out selectively advantaged traits. The fundamental theorem assumes evolution is noise free with respect to fitness, that advantageous traits always result in more offspring. We know empirically and theoretically this cannot possibly be true even on the approximate model of Mendelian inheritance.

For reasons such as those I laid out, many believe molecular evolution had to be mostly invisible to selection. Attributing even 5% of molecular evolution to Darwinism would be extremely generous. See: Kimura’s Neutral Theory.

Kimura gave an obligatory salute to Darwin by claiming adaptational features (like morphology) are exempt from his math. I’ve seen nothing supporting Kimura’s obligatory salute to Darwin. It seems his neutralist ideas apply quite well to realms beyond the molecular. NAS member Masotoshi Nei has finally been bold enough to assert most everything else about evolution, not just molecular evolution, is under much less selection pressure than previously assumed. I think Nei is right.

Yesterday afternoon I showed Kimura’s books to an ID-friendly senior in biology. His jaw dropped. He had studied molecular genetics, but our conversation yesterday helped him make the connections he had not made before. The math clearly indicates Darwin couldn’t possibly be right, and by way of extension, neither can Richard Dawkins.

These fairly obvious considerations were not lost upon Michael Lynch:

the uncritical acceptance of natural selection as an explanatory force for all aspects of biodiversity (without any direct evidence) is not much different than invoking an intelligent designer

Michael Lynch
The Origins of Genome Architecture, p 368

Notes:

1. I created a Microsoft Excel Spreadsheet is provided for illustration of these concepts. I used a random number generator to simulate the progress of 10 equally skilled gamblers in a casino. Press the “F9” to redraw the graph. One can see that even “selectively” advantaged individuals can lose. The important thing to grasp is that “slight selective” advantages do not look very different from random walks except in the long run. The problem for natural selection in the wild is that there usually is no “long run” for a newly emerged trait if it suffers from gamblers ruin. The “long run” exists for skilled and intelligent risk managers like Edward Thorp, it does not exist, statistically speaking, for most selectively advantageous traits.

A copy of my spreadsheet can be accessed here.

Sometimes pressing “F9” will cause most of the gamblers to win, and other time it will cause most of them to lose. This underscores the strong effect of random events even when one possess an inherent statistical advantage such as a gambling skill or a selectively advantaged trait.

2. Here is a nice pic of Bill with a standard casino die.

In the 1970’s, casinos had to redesign their craps tables in order to foil skilled dice throwers who exploited slightly non-random behaviors of dice. Las Vegas laws were passed that prevented skilled players from using there specially designed tosses which would exhibit non-random, statistically advantageous behavior.

Some people still claim to be able to influence dice so as to create non-random outcomes in a legal way. However, even skilled crap shooters need principles of risk management and precautions against gambler’s ruin to succeed.

[UPDATE:

1. 5/5/08 World Renowned Geneticist Joe Felsenstein responds to my essay here: Gambler’s Ruin is Darwin’s Gain.

2. 5/5/08 HT: ICON-RIDS:

Natural Selection is daily and hourly scrutinising, throughout the world, the slightest variations; rejecting those that are bad, preserving and adding up all that are good.

C.DARWIN sixth edition Origin of Species — Ch#4 Natural Selection

This is an even better quote showing how wrong Darwin was in light of these discussions.

See: this comment

3. Thanks to pantrog of PT for his editorial correction about sickle cell anemia. That was my editorial mistake not seeing it in the first place. My error was pointed out here here.

4. 5/8/08 One could easily modify the spreadsheet to stop progress when zero is hit, except if I did this, one would not easily see all the lines since most of them abort early thus giving a misleading impression of large scale progress. See this comment:
Comment about Spreadsheet

5. I wrote: If he has a 1% statistical advantage, that means he has a 50.5% chance of winning and a 49.5% chance of losing. To clarify, the outcomes are complicated by double-downs, splits, and blackjacks, etc. so the notion of “win” in this thread is effective average win over time per round….I didn’t want to get into these deep specifics earlier as it was peripheral to the thread…

6. 5/31/08 In response to various comments by those at UD and PandasThumb, I created another spreadsheet with some improvements. See the improvements at: ruin_olegt_mod1.xls. The princple changes were in response to suggestions by a very fine physicist by the name of Olegt who sometimes posts at TelicThoughts and PT. The new simulation has more rounds and actually prevents a player from playing once he is ruined.

]

Comments
Are you saying that the f(x) in the Fourier Integral Theorem does not satisfy the following properties.
on every finite interval, f(x) is bounded and has at most a finite number of local maxima and minima and a finite number of discontinuities
scordova
June 6, 2008
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What strikes me particularly ironic is that Apostol in the book you presented doesn't even use Dirichlet conditions regarding the convergence of a Fourier series. He gives to other criteria: 1. Jordan's test and 2. Dini's test (both Tom Mike Apostol: Mathematical Analysis 2nd ed., p. 319)DiEb
June 6, 2008
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-Sal, do me - do yourself - a favour and read the following paragraph carefully (or, at least, read it at all.) This may spare you some future embarrassment: In mathematics, many concepts are named after great mathematicians. Some of those have even different concepts bearing their names. Though these concepts are often intertwined, most times they are not exchangeable: a question about Gaussian integers can't be answered with hinting to a Gaussian distribution (though there may be exceptions :-) )... Sometimes, even one name may describe two different concepts - and you have to be aware in which branch of mathematics you're at the moment: Dirichlet conditions normally refer to Fourier series, but it may be a short form for Dirichlet boundary conditions, a concept from the world of PDEs. For short: One should always read mathematical texts carefully, and not mix up different concepts - only because they are sounding similarly. So, what have you done, Sal? I stated that one generally wouldn't apply Dirichlet conditions to aperiodic functions. You hint me to a text where - in the proof of the Fourier integral theorem a Dirichlet integral is used. Read the text carefully, and you'll see, that the conditions for the function of the theorem are not the Dirichlet conditions, but a) a kind of locally bounded variation or b) a condition for the right and left limit of the function at a point. That is a very sloppy example of equivocation!DiEb
June 6, 2008
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DiEB climed: Re aperiodic functions - one could, but one wouldn’t:
If I may say, "oh really?" From Mathematical Analysis 2nd edition by Apostol page 323-324
if the given function is already defined everywhere on (-infinity, +infinity) and is not periodic, then there is no hope of obtainin a Fourier series which represents the function everywhere on (-infinity, +infinity). Nevertheless, in such a case the function can sometimes be represented by an infinite integral rather than by an infinite series. These integrals, which are in many ways analogous to Fourier series, are known as Fourier integrals, and the theorem which gives sufficient conditions for representing a function by such an integral is known as the Fourier integral theorem. The basic tools used in the theory are, as in the case of Fourier series, the Dirichlet integrals and the Riemann-Lebesgue lemma.
scordova
June 6, 2008
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Sal- I don't know what you want to achieve by posing your little questions (and yes, every Riemann-integrable function is Lebesgue-integrable)... Just out of curiosity: can you trade your three undergrad degrees for one graduate degree?DiEb
June 6, 2008
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You're obfuscating again DiEB. I use the obfuscating becuse the term I 'd rather use (but is more appropriate) is a bit uncivil. But I'll be nice to you, since you're humoring my questions.
Perhaps, I should have elaborated my last answer a little bit, as you don’t seem to be familiar with the concept of Lebesgue integration:
I happen to have 3 undergrad degrees, one in mathematics. I do seem to recall studying Lebesgue integrable functions and I happen to still have the textbooks which discuss Lebesgue integration, several on Fourier Transforms. In fact one of my textbooks delves into the relationship of Dirichlet integrals, Fourier Integrals, Riemann-Lebesgue lemma, etc. I sense you just bungled a bit with your last answer. hehehe And let me show you why. To do so, let me back up a bit. Are Riemann integrable functions also Lesbegue integrable? That should be an easy enough question for you. One which you shouldn't obfuscate. Your answer will lead to discussion of other issues, not the least of which will demonstrate you just bungled one of your answers. :-)scordova
June 6, 2008
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How exasperating - once more, with feeling: f ≅ g : ⇔ μ{f≠g}=0 And if this doesn't show up right: Two functions are said to be equivalent iff they differ only on a null-set. BTW: Sal - your spelling of Dirichlet improved - congrats! Is there anywhere a list of tags which can be used safely in this forum? The preview window at least is sensitive to another set of tags then the post itself ( and for example)DiEb
June 6, 2008
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I'll give the equivalence relation again, as parts of it don't appear: f ~ g iff μ{f=g}=0DiEb
June 6, 2008
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Perhaps, I should have elaborated my last answer a little bit, as you don't seem to be familiar with the concept of Lebesgue integration: when we are speaking of a function in Lp, we use a kind of sloppy language as we really speak about a class of functions, the equivalence class of functions under the relation: f ~ g μ{f=g}=0 So, in this concept, your question doesn't make much sense. OTOH, as you're thinking in Fourier series, you may take a look at the behaviour of a periodic function on an interval at its points of discontinuity: the actual value at this point doesn't influence the Fourier series, as the sum of the Fourier series in this points is given by the mean of the left and the right limit of the function at this point...DiEb
June 6, 2008
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Quotemining seems to be becoming a habit of yours... I wrote: Re aperiodic functions - one could, but one wouldn’t: yes, you found a script where for motivational reasons aperiodic functions were regarded as a limit case of periodic functions. This is quite artificial: you could compare it to gluing moths to trees just to illustrate a point of interest of your students… it’s not what happens in the real world, but it’s close enough. The second part of this paragraph (not the bold part you quoted) shows that your conclusion
But one did: You seem to forget this little item here :-) If on every finite interval, f satisfies the Dirichlet conditions and if the improper integral exists, the following integral … is known as the Fourier transform, Try harder DiEB. :-)
isn't - how to phrase this civilly - anchored in reality, as this second part is just about "this little item here".
So DiEB, now that I’ve disproven your claim that one wouldn’t use Dirichlet conditions to identify functions with sufficient conditions to have a Fourier transform, are you going to continue to argue otherwise?
I'm afraid you have disproven nothing...
By the way, just so I can be assured of your knowledge on the matter. Can there be two functions say f(x) and g(x), and there exists some x where f(x) not equal to g(x), but their Fourier Transforms are equivalent?
Ever heard of the concept of a null-set?DiEb
June 6, 2008
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Re aperiodic functions - one could, but one wouldn’t:
But one did: You seem to forget this little item here :-)
If on every finite interval, f satisfies the Dirichlet conditions and if the improper integral exists, the following integral … is known as the Fourier transform,
Try harder DiEB. :-) So DiEB, now that I've disproven your claim that one wouldn't use Dirichlet conditions to identify functions with sufficient conditions to have a Fourier transform, are you going to continue to argue otherwise? Please don't obfuscate as you usually do. This is a simple question. PS By the way, just so I can be assured of your knowledge on the matter. Can there be two functions say f(x) and g(x), and there exists some x where f(x) not equal to g(x), but their Fourier Transforms are equivalent?scordova
June 5, 2008
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1. Your post #133 answers to my post #15 - Thanks. 2. Do you know for a FACT that I did not know the difference between a Fourier Series and Fourier Transform? For a FACT? Heck, for what I know, you could be Hilbert reincarnated. But by the entries of your blog, you succeeded in giving the impression that you are standing at the very beginning of your journey into the interesting world of Fourier Analysis. You should read your articles in one year from now, again and judge for yourself... 3. In certain conventions, are Dirichelet [sic] conditions applicable to determining if a function can have Fourier Transform, even aperiodic functions? Re aperiodic functions - one could, but one wouldn't: yes, you found a script where for motivational reasons aperiodic functions were regarded as a limit case of periodic functions. This is quite artificial: you could compare it to gluing moths to trees just to illustrate a point of interest of your students... it's not what happens in the real world, but it's close enough. 4. How about it DiEB…do functions satisfying Dirichelet [sic] conditions have fourier Transforms? In this context, this question is ill-posed - see above :) PS: Do I know for a FACT that you can't spell the name of Johann Peter Gustav Lejeune Dirichlet? No, of course not, but somehow you manage to impersonate someone who can't...DiEb
June 1, 2008
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5/31/08 In response to various comments by those at UD and PandasThumb, I created another spreadsheet with some improvements. See the improvements at: ruin_olegt_mod1.xls. The princple changes were in response to suggestions by a very fine physicist by the name of Olegt who sometimes posts at TelicThoughts and PT. The new simulation has more rounds and actually prevents a player from playing once he is ruined.scordova
May 31, 2008
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I'm monitoring this thread. I don't want DiEB to get away with false accusations. He can offer an apology for spreading falsehoods about me or answer the questions I posed. How about it DiEB...do functions satisfying Dirichlet conditions have fourier Transforms? :-)scordova
May 30, 2008
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Sal has noticed. He revived the thread with his last post, #124, which appeared twenty days after the previous post from DiEb. Sal and DiEb are having a very. slow. argument. DiEb, use carets <>, not square brackets, for format statements. HTH!Tom MH
May 30, 2008
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Anytime you have two PhD's you have a paradox.thogan
May 30, 2008
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I don't know if Sal has even noticed that you guys are commenting here...Patrick
May 30, 2008
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BTW, weren't it for the plucky folks of AtBC, I'd never found that Sal revived this thread after [i]three weeks[/i]...DiEb
May 29, 2008
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Trying to post a paradox: "This post doesn't appear" FYI: my last tries to post something on this board weren't dignified with the usual "your post is awaiting moderation" screen, but didn't appear at all. I'll give it a shot...DiEb
May 29, 2008
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Dieb can post a comment, but he'll need to wait until it's released from moderation by an admin.Patrick
May 29, 2008
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You shouldn’t have too much problem answering these simple questions should you?
It would probably be easier for him if his posts were allowed to appear.Lormy Kathorpa
May 29, 2008
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You assume wrong DiEb as this thread has now run its course, we can settle the issue. Do you know for a FACT that I did not know the difference between a Fourier Series and Fourier Transform? In certain conventions, are Dirichelet conditions applicable to determining if a function can have Fourier Transform, even aperiodic functions? You shouldn't have too much problem answering these simple questions should you?scordova
May 29, 2008
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-Sal, I assume that no one wants to rehash this discussion. As I said, I followed your musings - and I didn't find your presentation convincing: you seem to answer your critiques sometimes on a google-first-hit basis (as above with your link for the thermodynamics vs. heat flow question). This behaviour suggests that you haven't fully incorporated the underlying (mathematical) knowledge for the topics in debate. But of course, that's just my subjective impression - nevertheless, I've to work with it for my Bayesian classifier :-)DiEb
May 9, 2008
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You promoted falsehoods about me regarding Fourier transforms. I have no reason to give you air time here at UD until you offer a retraction. Do you still maintain that I don't know the difference between and Fourier Series versus a Fourier Transform?scordova
May 9, 2008
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- Sal 1. Thanks for adding your caveat 2. Do trust me then. Sorry, I followed your musings about the Fourier Transform - I'm afraid it will take its time before I trust you anywhere in the regions of higher mathematics. Sorry, if I'm sounding uncharitable...DiEb
May 9, 2008
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So, why this nitpicking? If you don’t get the easy things right, i.e., a simple model of gambler’s ruin as an excel-sheet, how can I trust you with the more complicated concepts of your post?
Where did I say it was nit picking?. The graph was to ILLUSTRATE:
The important thing to grasp is that “slight selective” advantages do not look very different from random walks except in the long run. This underscores the strong effect of random events even when one possess an inherent statistical advantage such as a gambling skill or a selectively advantaged trait.
The name of the file had the word gambler's ruin to associate it with this discussion. It was not formally a simulation of actual ruin but ILLUSTRATE:
that “slight selective” advantages do not look very different from random walks except in the long run.
One could easily modify the spreadsheet to stop progress when zero is hit, except if I did this, one would not easily see all the lines since most of them abort early thus giving a misleading impression of large scale progress.
If you don’t get the easy things right, i.e., a simple model of gambler’s ruin as an excel-sheet, how can I trust you with the more complicated concepts of your post?
Do trust me then. I updated the above post to add a caveat in light of you most uncharitable reading of what I wrote.scordova
May 8, 2008
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Hm, the preview shows me, that my tags have an effect - which is lost in the displayed post... that's quite annoying!DiEb
May 7, 2008
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Sal - in #15, I criticized your spread-sheet. I'd like to elaborate a little bit: Your spread-sheet doesn't reflect the problem you discuss, i.e., gambler's ruin. This fact gets hidden by the type of diagram you chose: the cumulated sum of paths... The problem: a path doesn't stay at zero once it reached zero, in other words: you are looking at a process {Sn}n∈N with P(Sn+1-Sn=d)=p, P(Sn+1-Sn=-d)=1-p=q and S0≡K, where K is your starting capital and d is the possible gain or loss in each game (you chose K=d=50) - while you should have looked at the stopped process {Sτ∧n}n∈N, τ:=inf{k:Sk=0}.... The difference becomes obvious when you take the expected value after a couple of rounds. What's the average capital after the 77 rounds in your spread-sheet? It's 103.9. And what happens if we take K=0 or K=-50? Well, on average we get a capital of 53.9 resp. 3.9 - and that cannot be as a bankrupted gambler isn't allowed to play. A quick calculation yields: S0 - E[S77] - E[Sτ∧77] 0 - 53.9 - 0 50 - 103.9 - 59.8 100 - 153.9 - 118.0 150 - 203.9 - 175.0 200 - 253.9 - 230.8 250 - 303.0 - 285.5 500 - 553.9 - 548.8 1000 - 1053.9 - 1053.7 So, why this nitpicking? If you don't get the easy things right, i.e., a simple model of gambler's ruin as an excel-sheet, how can I trust you with the more complicated concepts of your post?DiEb
May 7, 2008
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Gentleman, I'll be on travel for a bit, but I'll return. I also have a discussion at PT ongoing. I have to be cordial there as a professor from my school is also participating and it is my hope we conduct ourselves in a manner which honors the institution we are a part of. He has certainly been cordial to me and I'll endeavor to reciprocate. Also, Dr. Peter Oloffson e-mailed me this, and I thought I'd pass it on (nothing sensiive or private):
Just read your post about gambling. As a Swede I have to point out that there is no "true" Nobel Prize in Economics. Alfred Nobel was smart enough not to include it in his will and it was instituted by the Bank of Sweden much later.
scordova
May 7, 2008
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Sal -
I don’t think Kondrashov’s soft selection solution or “synergistic epistasis” is the answer, but I would welcome hearing the other side.
This is not a debate I've been following, but some of the work on evolution of sex in finite populations is relevant to Kondrashov's work. Sally Otto talked about them at the ESEB meeting last year.
PS By the way, if you’d like Bob OH, I’d be happy to mail you Genetic Entropy as my personal thanks for your participation here at UD.
Thank you, I'd be grateful. Do you have my address? If not, email me (or google me, and make sure you send it to the guy in Helsinki!). JunkyardTornado -
Not clear why seperate mutations would have to be acted upon independently. If its a phenotype that’s rejected wouldn’t the associated genes (plural) decrease in frequency.
Yes, you're right. But if the genes are independent (technically if there is no epistasis or linkage disequilibrium) then at the population level they can be treated as being independent. I had been intending to chase up the maths, but other stuff intervened.Bob O'H
May 7, 2008
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