Good advice. In a study of fruit fly pupae:
Tohoku University scientists have, for the first time, provided experimental evidence that cell stickiness helps them stay sorted within correct compartments during development. How tightly cells clump together, known as cell adhesion, appears to be enabled by a protein better known for its role in the immune system. The findings were detailed in the journal Nature Communications.
Scientists have long observed that not-yet-specialized cells move in a way that ensures that cell groups destined for a specific tissue stay together. In 1964, American biologist Malcolm Steinberg proposed that cells with similar adhesiveness move to come in contact with each other to minimize energy use, producing a thermodynamically stable structure. This is known as the differential adhesion hypothesis.
“Many other theoretical works have emphasized the importance of differences in cell-to-cell adhesion for separating cell populations and maintaining the boundaries between them, but this had not yet been demonstrated in living animal epithelial tissues,” says Erina Kuranaga of Tohoku University’s Laboratory for Histogenetic Dynamics, who led the investigations. “Our study showed, for the first time, that cell sorting is regulated by changes in adhesion.“Tohuku University, “Protein tells developing cells to stick together” at ScienceDaily
Paper. Open access.
Move along, folks. No design to see here.