All computational evolutionary algorithms artificially isolate the effects of random mutation on the underlying machinery: the CPU instruction set, operating system, and algorithmic processes responsible for the replication process.
If the blind-watchmaker thesis is correct for biological evolution, all of these artificial constraints must be eliminated. Every aspect of the simulation, both hardware and software, must be subject to random errors.
Of course, this would result in immediate disaster and the extinction of the CPU, OS, simulation program, and the programmer, who would never get funding for further realistic simulation experiments.