Thought you all might be interested in this video on whether or not mutations are random. It covers both why we originally thought mutations were random plus more current information which shows that the random mutation idea is not the whole picture.
The references are a little hard to read in YouTube, so here they are:
- Kondrashov. 1995. Contamination of the Genome by Very Slightly Deleterious Mutations: Why Have We Not Died 100 Times Over? Journal of Theoretical Biology 175(4):583-594.
- Templeton. 2006. Population Genetics and Microevolutionary Theory.
- Orgel and Crick. 1980. Selfish DNA: The Ultimate Parasite. Nature 284:604-607.
- Chuang and Li. 2004. Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions of the Human Genome. PLoS Biology 2(2)e29.
- Hall. 1999. Transposable Elements as Activators of Cryptic Genes in E. Coli. Genetica 107:181-187.
- Market and Papavasiliou. 2003. V(D)J Recombination and the Evolution of the Adaptive Immune System. PLoS Biology 1(1):e16.
- Papavasiliou and Schatz. 2002. Somatic Hypermutation of Immunoglobulin Genes: Merging Mechanisms for Genetic Diversity. Cell 109:S35-44.
- Fondon and Garner. 2004. Molecular Origins of Rapid and Continous Morphological Evolution. PNAS 101:18058-18063.
- Barry. 2006. Implicit Information in Eukaryotic Pathogens as the Basis of Antigenic Variation. In The Implicit Genome, Oxford University Press.