Closing in on how early life stress changes epigenetic markers

_{Denyse O'Leary

March 23, 2021

Epigenetics, Intelligent Design}

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The good news from this mouse study is that if epigenetic stress is recognized, it can be reversed. That means, presumably, that it won’t be passed on:

In a study published March 15 in Nature Neuroscience, researchers found that early-life stress in mice induces epigenetic changes in a particular type of neuron, which in turn make the animals more prone to stress later in life. Using a drug that inhibits an enzyme that adds epigenetic marks to histones, they also show that the latent effects of early-life stress can be reversed.
“It is a wonderful paper because it is really advancing our ability to understand how events that happen early in life leave enduring signatures in the brain so that they influence what we do as adults,” says Tallie Z. Baram, a child neurologist and developmental neurobiologist at the University of California, Irvine, who wasn’t involved with the study.
Asher Jones, “Early-Life Stress Exerts Long-Lasting Effects Via Epigenome” at The Scientist

All the more reason to blow clear of Darwinian determinism about genetics.

The paper is open access.

See also: Epigenetic change: Lamarck, wake up, you’re wanted in the conference room!

Comments

What a clueless ass, you are, JVL.
So, that makes oral sex and masturbation off limits because hands and mouths were also not intended to be used for sexual purposes.
That doesn't follow.. Also I said that the anus was part of the excretory system. And YOU don't have any clue about biology or anatomy. Hands are used to feel, touch, caress, grasp= a multitude of functions. Mouths also have a multitude of functions. You are clearly just a desperate and clueless ass.ET_{March 25, 2021
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And how did we get from protecting human life in the womb to where we are now? "abortion activists" Just another tribe forcing their beliefs on everyone else, even if it kills them. Andrewasauber_{March 25, 2021
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So how did we go from a “sociopathic personality disturbance” to where we are now? "gay activists" Andrewasauber_{March 25, 2021
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ET: Make your case and stop being such an infant. You said anus's should not be used for sexual purposes because that's not what they were intended to be used for. So, that makes oral sex and masturbation off limits because hands and mouths were also not intended to be used for sexual purposes.JVL_{March 25, 2021
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"Actually, yes, by our betters." Sev, Not ours. Not mine. Yours. Andrewasauber_{March 25, 2021
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Make your case and stop being such an infant.ET_{March 25, 2021
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ET: That doesn’t follow. What are mouths and hands intended to be used for?JVL_{March 25, 2021
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JVL:
So, oral sex is wrong as well. And masturbation.
That doesn't follow.ET_{March 25, 2021
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ET: Biology says that the anus is part of the EXCRETORY system. So those who use it for something it was not intended for obviously have a mental disorder. So, oral sex is wrong as well. And masturbation.JVL_{March 25, 2021
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Biology says that the anus is part of the EXCRETORY system. So those who use it for something it was not intended for obviously have a mental disorder.ET_{March 25, 2021
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seversky:
So she was tacitly but knowingly appealing to unreasonable people?
So she was appealing to democrats. Weird.ET_{March 25, 2021
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Oh, here we go again on everybody's favorite topic: homosexuality. Well, if we can't agree whether it is inborn, perhaps it will be less controversial that it is an evolutionarily maladaptive trait, i.e., a trait that is not favored by evolution.EDTA_{March 24, 2021
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Maybe homosexuality is a "sin" and/or mental disorder, maybe it isn't (I couldn't care less), but let's not pretend that some psychobabble "consensus" is any sort of determinant. "Science" + politics = politics.Concealed Citizen_{March 24, 2021
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Hmm, Seversky, all of the sudden, is into psychological studies? But why does Seversky not listen to these psychologists?
"Life is never made unbearable by circumstances, but only by lack of meaning and purpose." - Viktor Frankl - Man's Search for Meaning - 1946 - Austrian psychiatrist, Auschwitz survivor https://www.travelerstoday.com/articles/8798/20140215/book-happiness-written-man-who-suffered.htm
Hmm, and Darwinian materialism just so happens to deny that there is any real meaning and purpose to life.
"Let me summarize my views on what modern evolutionary biology tells us loud and clear — and these are basically Darwin’s views. There are no gods, no purposes, and no goal-directed forces of any kind. There is no life after death. When I die, I am absolutely certain that I am going to be dead. That’s the end of me. There is no ultimate foundation for ethics, no ultimate meaning in life, and no free will for humans, either. What an unintelligible idea." - William Provine - 1994
No wonder atheists have such problems with their mental health, and live significantly shorter lives, and commit suicide at a much greater rate, than people who believe in God. As Professor Andrew Sims, former President of the Royal College of Psychiatrists, states, “The advantageous effect of religious belief and spirituality on mental and physical health is one of the best-kept secrets in psychiatry and medicine generally.”,,, “In the majority of studies, religious involvement is correlated with well-being, happiness and life satisfaction; hope and optimism; purpose and meaning in life;,,”
“I maintain that whatever else faith may be, it cannot be a delusion. The advantageous effect of religious belief and spirituality on mental and physical health is one of the best-kept secrets in psychiatry and medicine generally. If the findings of the huge volume of research on this topic had gone in the opposite direction and it had been found that religion damages your mental health, it would have been front-page news in every newspaper in the land.” - Professor Andrew Sims former President of the Royal College of Psychiatrists - Is Faith Delusion?: Why religion is good for your health - preface “In the majority of studies, religious involvement is correlated with well-being, happiness and life satisfaction; hope and optimism; purpose and meaning in life; higher self-esteem; better adaptation to bereavement; greater social support and less loneliness; lower rates of depression and faster recovery from depression; lower rates of suicide and fewer positive attitudes towards suicide; less anxiety; less psychosis and fewer psychotic tendencies; lower rates of alcohol and drug use and abuse; less delinquency and criminal activity; greater marital stability and satisfaction… We concluded that for the vast majority of people the apparent benefits of devout belief and practice probably outweigh the risks.” - Professor Andrew Sims former President of the Royal College of Psychiatrists - Is Faith Delusion?: Why religion is good for your health – page 100 https://books.google.com/books?id=PREdCgAAQBAJ&pg=PA100#v=onepage&q&f=false Study: Religiously affiliated people lived “9.45 and 5.64 years longer…” July 1, 2018 Excerpt: Self-reported religious service attendance has been linked with longevity. However, previous work has largely relied on self-report data and volunteer samples. Here, mention of a religious affiliation in obituaries was analyzed as an alternative measure of religiosity. In two samples (N = 505 from Des Moines, IA, and N = 1,096 from 42 U.S. cities), the religiously affiliated lived 9.45 and 5.64 years longer, respectively, than the nonreligiously affiliated. Additionally, social integration and volunteerism partially mediated the religion–longevity relation. https://uncommondescent.com/intelligent-design/study-religiously-affiliated-people-lived-religiously-affiliated-lived-9-45-and-5-64-years-longer/ Can Religion Extend Your Life? - By Chuck Dinerstein — June 16, 2018 Excerpt: The researcher's regression analysis suggested that the effect of volunteering and participation accounted for 20% or 1 year of the impact, while religious affiliation accounted for the remaining four years or 80%. https://www.acsh.org/news/2018/06/16/can-religion-extend-your-life-13092 "Concerning suicide rates, this is the one indicator of societal health in which religious nations fare much better than secular nations. According to the 2003 World Health Organization's report on international male suicides rates (which compared 100 countries), of the top ten nations with the highest male suicide rates, all but one (Sri Lanka) are strongly irreligious nations with high levels of atheism. It is interesting to note, however, that of the top remaining nine nations leading the world in male suicide rates, all are former Soviet/Communist nations, such as Belarus, Ukraine, and Latvia. Of the bottom ten nations with the lowest male suicide rates, all are highly religious nations with statistically insignificant levels of organic atheism."[3] https://www.conservapedia.com/Atheism_and_suicide
it is also interesting to note that learning and reading about the afterlife and/or about Near Death Experiences is 'generally quite successful not only in reducing suicidal thoughts but also in preventing the deed altogether".,,,
Knowledge of the afterlife deters suicide. Lessons From the Light by Kenneth Ring and Evelyn Elsaesser p.257-258: As far as I know, the first clinician to make use of NDE material in this context was a New York psychologist named John McDonagh. In 1979, he presented a paper at a psychological convention that described his success with several suicidal patients using a device he called “NDE bibliotherapy.” His “technique” was actually little more than having his patients read some relevant passages from Raymond Moody’s book, Reflections on Life after Life, after which the therapist and his patient would discuss its implications for the latter’s own situation. McDonagh reports that such an approach was generally quite successful not only in reducing suicidal thoughts but also in preventing the deed altogether.,,, Since McDonagh’s pioneering efforts, other clinicians knowledgeable about the NDE who have had the opportunity to counsel suicidal patients have also reported similar success. Perhaps the most notable of these therapists is Bruce Greyson, a psychiatrist now at the University of Virginia, whose specialty as a clinician has been suicidology. He is also the author of a classic paper on NDEs and suicide which the specialist may wish to consult for its therapeutic implications. (14) Quite apart from the clinicians who have developed this form of what we might call “NDE-assisted therapy,” I can draw upon my own personal experience here to provide additional evidence of how the NDE has helped to deter suicide. The following case,,, http://ncu9nc.blogspot.com/2015/03/video-lecture-by-john-lennox-explains.html
Verse:
Proverbs 8: 33- 36 Listen to instruction and be wise; do not ignore it. Blessed is the man who listens to me, watching daily at my doors, waiting at the posts of my doorway. For whoever finds me finds life and obtains the favor of the LORD. But he who fails to find me harms himself; all who hate me love death.”
bornagain77_{March 24, 2021
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Asauber/9
“Seversky: Since homosexuality is no longer considered a disorder Hehe, well, by whom?” Sev’s Betters.
Actually, yes, by our betters.
Out of DSM: Depathologizing Homosexuality Jack Drescher Abstract In 1973, the American Psychiatric Association (APA) removed the diagnosis of “homosexuality” from the second edition of its Diagnostic and Statistical Manual (DSM). This resulted after comparing competing theories, those that pathologized homosexuality and those that viewed it as normal. In an effort to explain how that decision came about, this paper reviews some historical scientific theories and arguments that first led to the placement of homosexuality in DSM-I and DSM-II as well as alternative theories that eventually led to its removal from DSM III and subsequent editions of the manual. The paper concludes with a discussion of the sociocultural aftermath of that 1973 decision. […] 8. Conclusions APA’s 1973 diagnostic revision was the beginning of the end of organized medicine’s official participation in the social stigmatization of homosexuality. Similar shifts gradually took place in the international mental health community as well. In 1990, the World Health Organization removed homosexuality per se from the International Classification of Diseases (ICD-10) [64]. As a consequence, debates about homosexuality gradually shifted away from medicine and psychiatry and into the moral and political realms as religious, governmental, military, media, and educational institutions were deprived of medical or scientific rationalization for discrimination. As a result, cultural attitudes about homosexuality changed in the US and other countries as those who accepted scientific authority on such matters gradually came to accept the normalizing view. For if homosexuality was no longer considered an illness, and if one did not literally accept biblical prohibitions against it, and if gay people are able and prepared to function as productive citizens, then what is wrong with being gay? Additionally, if there is nothing wrong with being gay, what moral and legal principles should the larger society endorse in helping gay people openly live their lives? […] Most importantly, in medicine, psychiatry, and other mental health professions, removing the diagnosis from the DSM led to an important shift from asking questions about “what causes homosexuality?” and “how can we treat it?” to focusing instead on the health and mental health needs of LGBT patient populations
Seversky_{March 24, 2021
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Darwinian evolution is a deeply held false belief of many people
Some of them are extremely smart. So it shows how superficial the knowledge is amongst the very intelligent even when it’s the basis for their theories of the world. Matt Ridley is an interesting writer with a PhD in biology. He writes about science topics as well as other things. He has written a book on innovation that I am currently reading. In it he assumes evolution or natural selection is true. He had a couple podcasts last June with Naval Ravikant who is also considered a brilliant thinker and who is deeply supportive of natural selection as the basis for his worldview. Holding beliefs in natural selection does not interfere with how they view the world works. So they accept it. My guess is that both would be extremely shaken to know that their understanding is baseless. Aside: Ridley believes that freedom is the basis for innovation but does not understand the uniqueness of England and how freedom essentially arose only there. (And to a lesser extent in Holland) Back to epigenetics. It seems they have only scratched the surface of it so far. Especially if it can be reversed with a treatment such as described in the video. .jerry_{March 24, 2021
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Oh goody, science denial at it finest. i.e. I personally don't like the findings therefore I choose not to believe them. To repeat,
Born gay or transgender: Little evidence to support innate trait, Wednesday, August 24, 2016 Excerpt: “a report finds scarce scientific evidence to conclude that gay and transgender people are “born that way. The 143-page paper, published this week in The New Atlantis journal, combs through hundreds of studies in search of a causal, biological explanation for sexual orientation and gender identity, but comes up empty. “The belief that sexual orientation is an innate, biologically fixed human property — that people are ‘born that way’ — is not supported by scientific evidence,” says the report, written by a psychiatrist and a biostatistician at Johns Hopkins University. “Likewise, the belief that gender identity is an innate, fixed human property independent of biological sex — so that a person might be a ‘man trapped in a woman’s body’ or a ‘woman trapped in a man’s body’ — is not supported by scientific evidence,”” http://www.washingtontimes.com/news/2016/aug/24/born-gay-transgender-lacks-science-evidence/ There’s no evidence that a single ‘gay gene’ exists – Aug. 2019 Excerpt: First reported at a genetics conference in 2018, the study found five genetic variants associated with having a same-sex sexual partner (SN: 10/20/18). But those variants, called SNPs, don’t predict people’s sexual behavior, researchers report in the Aug. 30 Science. “There is no ‘gay gene’ that determines whether someone has same-sex partners,” says Andrea Ganna, a geneticist at the Broad Institute of MIT and Harvard and the University of Helsinki. https://www.sciencenews.org/article/no-evidence-that-gay-gene-exists
bornagain77_{March 24, 2021
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Baloney.Viola Lee_{March 24, 2021
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People harbor false beliefs all the time. For example, Darwinian evolution is a deeply held false belief of many people right here on UD. Yet, as the references I cited make clear, there simply is no scientific evidence to support the belief that homosexual people are 'born that way': It is a myth, even a lie, that simply has no basis in reality as far as the scientific evidence itself can tell us.bornagain77_{March 24, 2021
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Well, the homosexual people I know (some closely), certainly feel they were born that way, and think that those of you who think there is something wrong with them, or that they can be "fixed", are pretty heartless, putting your prejudices above your humanity. And I will once again point out that homosexual feelings based on the same mix of love, affection, companionship along with sexual attraction as heterosexuals have for the opposite sex.Viola Lee_{March 24, 2021
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As to: "Since homosexuality is no longer considered a disorder, does it matter?" Well, for young people who want to overcome any homosexual desires they may be having, and become a husband and/or a wife, and even have a family with children, I'm pretty sure that it matters very much for them to know that they are not completely helpless victims of their genes, i.e. to know that they are not 'born that way',
Born gay or transgender: Little evidence to support innate trait, Wednesday, August 24, 2016 Excerpt: "a report finds scarce scientific evidence to conclude that gay and transgender people are “born that way. The 143-page paper, published this week in The New Atlantis journal, combs through hundreds of studies in search of a causal, biological explanation for sexual orientation and gender identity, but comes up empty. “The belief that sexual orientation is an innate, biologically fixed human property — that people are ‘born that way’ — is not supported by scientific evidence,” says the report, written by a psychiatrist and a biostatistician at Johns Hopkins University. “Likewise, the belief that gender identity is an innate, fixed human property independent of biological sex — so that a person might be a ‘man trapped in a woman’s body’ or a ‘woman trapped in a man’s body’ — is not supported by scientific evidence,”" http://www.washingtontimes.com/news/2016/aug/24/born-gay-transgender-lacks-science-evidence/ There’s no evidence that a single ‘gay gene’ exists - Aug. 2019 Excerpt: First reported at a genetics conference in 2018, the study found five genetic variants associated with having a same-sex sexual partner (SN: 10/20/18). But those variants, called SNPs, don’t predict people’s sexual behavior, researchers report in the Aug. 30 Science. “There is no ‘gay gene’ that determines whether someone has same-sex partners,” says Andrea Ganna, a geneticist at the Broad Institute of MIT and Harvard and the University of Helsinki. https://www.sciencenews.org/article/no-evidence-that-gay-gene-exists
And, obviously, It is also important for them, (and for the rest of us), to know that we have an unexpectedly high level of control over the genetic expressions of our material bodies, and therefore we have a unexpectedly high level of control over any unwanted sexual desires that we may be having.
Networks of Genes Respond to Social Experiences - October 13, 2013 Excerpt: It is extremely surprising how networks of hundreds of genes respond immediately to human interactions and thoughts, despite the fact that actions of humans are eight orders of magnitude larger than molecular genetic events. But, it is, perhaps, more remarkable that networks of genes respond rapidly to social experiences. Previous posts have discussed the immediate neuroplasticity that occurs in widespread circuits with very complex detailed genetic production of new proteins, including motors, tubules, receptors, and neurotransmitters. The immune system does the same with cytokines, receptors, and antibodies. It is subjective mind and perception that changes genes, not just external situations. http://jonlieffmd.com/blog/networks-of-genes-respond-to-social-experiences
By the way, having 'top down' control of the genetic expressions of our material bodies also falsifies the Darwinian claim that we are completely helpless victims of our genes. That we are helpless 'Meat robots', as Jerry Coyne termed us.
“You are robots made out of meat. Which is what I am going to try to convince you of today” - Jerry Coyne – Darwinist and militant atheist - No, You’re Not a Robot Made Out of Meat (Science Uprising 02) – video https://youtu.be/rQo6SWjwQIk?list=PLR8eQzfCOiS1OmYcqv_yQSpje4p7rAE7-&t=20
Of supplemental note. Here are testimonies of deeply homosexual people who overcame their homosexuality, thus proving that the belief that it is impossible to overcome homosexual desires is a myth.
Such Were Some Of You - video https://www.youtube.com/watch?v=VKSFPdyH8x4 “Such Were Some of You” (A Documentary) was inspired by the passage in 1st Corinthians 6:11 that declares that in Jesus’ day there was a population who had been so transformed by their relationship with Him that they were no longer “same-sex attracted” or at the very least, actively homosexual. They had found such a measure of healing from the brokenness and strongholds associated with what we now call homosexuality that they no longer considered themselves homosexual, nor did they act in that way. “Such Were Some of You” features interviews with a “cloud of present-day witnesses” who testify to the same life-transforming power of Jesus Christ. They describe the development of their same-sex attractions, what the gay lifestyle was like, what their conversion process was like, and the various ways that Jesus has brought healing to their broken places. “Such Were Some of You” lays out the facts about healing homosexual confusion and rejoices in the reality that Jesus Christ can heal anyone from anything while providing grace for the journey. Extended Interviews with 29 former homosexuals who are now Christians GUESTS – THE EXTENDED INTERVIEWS - videos - Extended Interviews with 29 former homosexuals who are now Christians http://suchweresomeofyou.org/
It simply is not true that people are completely helpless over their sexual desires. Obviously we do exercise some level of sexual restraint and do not give into every sexual impulse that comes along. And thank God for that! :) . It is part of what makes us humans, not animals Verse
1 Corinthians 6: 11 And that is what some of you were. But you were washed, you were sanctified, you were justified in the name of the Lord Jesus Christ and by the Spirit of our God.
bornagain77_{March 24, 2021
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"Seversky: Since homosexuality is no longer considered a disorder Hehe, well, by whom?" Sev's Betters. Andrewasauber_{March 24, 2021
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Seversky: Since homosexuality is no longer considered a disorder Hehe, well, by whom? Some consensus of the biased? Okay. But at least be clear what you're saying.Concealed Citizen_{March 24, 2021
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Since homosexuality is no longer considered a disorder, does it matter?Seversky_{March 24, 2021
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It appears that it’s both, Very likely in epigenetic trigger for homosexuality twin studies point to that as well as multiple other studies are starting to show and epigenetic marker that goes with homosexuality And much like many of the conditions that you cannot say that there’s possibly something wrong with them well it turns out that there is a possible issue and abnormalityAaronS1978_{March 24, 2021
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Does homosexuality have a genetic or epigenetic origin? If epigenetic, does this mean it can be reversed? Could we be headed back to two sets of pronouns with the right therapy?jerry_{March 24, 2021
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Reversing an epigenetic change may sound like a form of repair, but it's likely to do the opposite. Learning happens for a reason, in short-term memory or in the super-long term epigenes. If one particular stress happens to the current generation in its current location, given the current conditions of weather and predators, the same stress is likely to continue for a couple more generations. This also applies to the more abstract types of predators, like demonic rulers in human cultures. Bad rulers are DYNASTIC. A generation that adjusts its epigenes to survive psychopathic monsters (as found in the 1400s and the 2000s) will pass on a USEFUL adaptation to the next generation who must survive the sons and daughters of the current monsters.polistra_{March 23, 2021
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Seversky “ So she was tacitly but knowingly appealing to unreasonable people?” It appears so. Good thing that nobody here was singing her tune of Dominion voting systems, Benford’s law, suitcases of ballots, mail-in ballots, out of state voters, deceased voters, and the statistical improbability of after-hour vote swings. :)Steve Alten2_{March 23, 2021
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“ Right-wing lawyer Sidney Powell is claiming in a new court filing that reasonable people wouldn’t have believed as fact her assertions of fraud after the 2020 presidential election.”
So she was tacitly but knowingly appealing to unreasonable people?Seversky_{March 23, 2021
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I know that this is off topic but I think it is important to bring up. “ Right-wing lawyer Sidney Powell is claiming in a new court filing that reasonable people wouldn't have believed as fact her assertions of fraud after the 2020 presidential election.” I guess that is one way to defend yourself: “No sane person should take me seriously.” But she wasn’t saying this back in the day. It’s a good thing that nobody here expended thousands of words making similar arguments. :)Steve Alten2_{March 23, 2021
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