Cell biology Intelligent Design

In Nature: Cells have “secret conversations”

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structure of an animal cell/royroydeb (CC BY-SA 4.0)

And they are “transforming biology”:

Close to three decades later, Vance’s paper is seen as a landmark — one that has come to transform scientists’ understanding of how cells maintain order and function in their crowded interiors, which buzz with various types of organelles, including mitochondria, nuclei and the ER. Researchers now recognize that interactions between organelles are ubiquitous, with almost every type coming into close conversation with every other type. Probing those connections is also leading biologists to discover proteins that are responsible for holding the organelles together and maintaining a healthy cell.

The updated view of organelle crosstalk is forcing a dramatic rethink of cell biology. “There’s a whole other layer of communication that’s going on within these organelles,” says Jennifer Lippincott-Schwartz, a cell biologist at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia, whose team has been recording dazzling video footage of these affairs.Elie Dolgin, “How secret conversations inside cells are transforming biology” at Nature

We say this a lot: That’s a lot of information to have simply come into being by natural selection acting on random mutation (Darwinism). It’s getting not only ridiculous but obviously ridiculous.

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5 Replies to “In Nature: Cells have “secret conversations”

  1. 1
    PeterA says:

    This is another “I told you so”case.

  2. 2
    PeterA says:

    Time to rewrite textbooks? Again?

    At the very least, says Voeltz, there’s enough evidence for cell-biology textbooks to get a makeover. She teaches an undergraduate course on organelle and membrane trafficking using a textbook, last revised in 2015, that depicts the cell just as it did 20 years ago. In fact, textbook depictions of the cell’s innards have changed little since 1896, when cytologist Edmund Beecher Wilson drew the cell with organelles neatly tucked into their own distinct cytoplasmic compartments.

    From the ER to the Golgi to the vacuole to the endosome, each organelle is still shown in isolation, not as a dynamic dance of parts that continuously embrace and separate. “Nothing is drawn the way the cell actually looks,” says Voeltz. “It would be nice to update that image.”

    Or better wait for the next research paper that will suggest more changes ?
    Or the one following the next?
    Or after that?
    Or simply have the textbooks online only?

    However, who cares about the accuracy of the textbooks?

  3. 3
    PeterA says:

    “We say this a lot: That’s a lot of information to have simply come into being by natural selection acting on random mutation (Darwinism). It’s getting not only ridiculous but obviously ridiculous“

    No, it’s been obviously ridiculous since long ago.

  4. 4
    bornagain77 says:

    The organization of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes, but the activities of these organelles must be coordinated. For example, lipid metabolism is distributed between the endoplasmic reticulum for lipid synthesis, lipid droplets for storage and transport, mitochondria and peroxisomes for ?-oxidation, and lysosomes for lipid hydrolysis and recycling1,2,3,4,5. It is increasingly recognized that organelle contacts have a vital role in diverse cellular functions5,6,7,8. However, the spatial and temporal organization of organelles within the cell remains poorly characterized, as fluorescence imaging approaches are limited in the number of different labels that can be distinguished in a single image9. Here we present a systems-level analysis of the organelle interactome using a multispectral image acquisition method that overcomes the challenge of spectral overlap in the fluorescent protein palette.
    https://www.nature.com/articles/nature22369

    video image – Systems-level spectral imaging and analysis have been applied to reveal the organelle interactome
    https://twitter.com/nature/status/869161463566417920?lang=en

  5. 5
    PeterA says:

    “In the cell, organelles are related directly to cell morphology and function. “

    “organelles, each of which has taken on a specialized role depending on the membrane and internal environment, support the complex activities of eukaryotic cells via the division of cellular functions.”

    “it traditionally was thought that these structures exist independently and do not interact with each other. However, recent studies have shown that intracellular membrane compartments engage in extensive communication, either indirectly or directly, through membrane contacts“

    “Because interorganelle communication controls important processes such as lipid metabolism and cell death, this crosstalk is essential for cell function, as well as tissue and organism homeostasis.”

    “…communication among organelles also is conducted through direct interactions at membrane contact sites (MCSs). Organelles exchange materials including lipids, ions, and proteins at the MCS. “

    Organelle crosstalk in the kidney
    Tsuyoshi Inoue, Hiroshi Maekawa, Reiko Inagi
    March 04, 2019
    PlumX Metrics
    DOI: 10.1016/j.kint.2018.11.035

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