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“Junk DNA” as a cause of cancer

File:DNA simple.svg

Useless is not the same as harmful, unfortunately. From ScienceDaily:

An Ontario-led research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the “dark matter” of human cancer DNA.

The mutation, as described in two related studies published in Nature on October 9, 2019, represents a new potential therapeutic target for several types of cancer including brain, liver and blood cancer. This target could be used to develop novel treatments for patients with these difficult-to-treat diseases.

“Non-coding DNA, which makes up 98 per cent of the genome, is notoriously difficult to study and is often overlooked since it does not code for proteins,” says Dr. Lincoln Stein, co-lead of the studies and Head of Adaptive Oncology at the Ontario Institute for Cancer Research (OICR). “By carefully analyzing these regions, we have discovered a change in one letter of the DNA code that can drive multiple types of cancer. In turn, we’ve found a new cancer mechanism that we can target to tackle the disease.”

The research group discovered that the mutation, termed the U1-snRNA mutation, could disrupt normal RNA splicing and thereby alter the transcription of cancer-driving genes. These molecular mechanisms represent new ways to treat cancers carrying the mutation. One of the potential treatment approaches includes repurposing existing drugs, which, by bypassing early drug development stages, could be brought into the clinic at an accelerated rate.

“Our unexpected discovery uncovered an entirely new way to target these cancers that are tremendously difficult to treat and have high mortality rates,” says Dr. Michael Taylor, Paediatric Neurosurgeon, Senior Scientist in Developmental and Stem Cell Biology and Garron Family Chair in Childhood Cancer Research at The Hospital for Sick Children (SickKids) and co-lead of the studies. “We’ve found that with one ‘typo’ in the DNA code, the resultant cancers have hundreds of mutant proteins that we might be able to target using currently available immunotherapies.” Paper 1 and Paper 2 paywalls – Hiromichi Suzuki et al., Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma. Nature, 2019; DOI: 10.1038/s41586-019-1650-0; Shimin Shua et al., The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature, 2019; DOI: 10.1038/s41586-019-1651-z More.

But, if things turn out as the researchers say, they now know what to target.

See also: Remember Junk RNA? Cell Division Requires A Balanced Level Of It

Off topic: What’s going on with TSZ lately they have lost so much internet traffic ? SW has done very well in the ranking lately. It has managed to move up substantially. now it’s less than 400k below UD! Perhaps this UD OP explains why PT does relatively well: https://uncommondescent.com/philosophy/new-another-philosopher-openly-dumps-darwinism-cites-its-acceptance-of-deception/ Also they have benefited from AH’s brilliant tornado theory. :) PS as expected has gone up impressively in their Alexa ranking, apparently after they had GP posting comments there. And now they should improve their ranking position even more after the new A&E book by JS comes out. Maybe someone at TSZ should write another book on A&E too? Or they should invite GP to teach them ID? :) UD. 693,792 SW. 1,079,467 PT. 1,812,569 PS. 4,807,211 TSZ. 7,000,628jawa
October 15, 2019
12:14 PM

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