'Junk DNA' Intelligent Design

“Junk” RNA plays key role in helping cells respond to stress

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From ScienceDaily:

A study from Massachusetts General Hospital (MGH) investigators has found a surprising role for what had been considered a nonfunctional “junk” RNA molecule: controlling the cellular response to stress. In their report in the Dec. 15 issue of Cell, the researchers describe finding that a highly specific interaction between two elements previously known to repress gene transcription — B2 RNA and EZH2, an enzyme previously known only to silence genes — actually induces the expression of stress-response genes in mouse cells.

Less than 2 percent of the genome in mammals actually codes for proteins, and for many years it was thought that noncoding DNA was a useless artifact. While some is translated into RNA molecules required for maintaining and regulating cellular functions — such as transfer RNA and microRNAs — the impression that most noncoding RNA serves no function has persisted. This has been particularly true for long noncoding RNAs and is even more the case for molecules transcribed from “parasitic” retrotransposons — repetitive DNA sequences inserted throughout the genome. But recent studies in mouse cells have indicated that RNA transcribed from the B2 retrotransposon binds to stress genes and suppresses their transcription. Paper. (paywall) – Athanasios Zovoilis, Catherine Cifuentes-Rojas, Hsueh-Ping Chu, Alfredo J. Hernandez, Jeannie T. Lee. Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell, 2016; 167 (7): 1788 DOI: 10.1016/j.cell.2016.11.041More.

The Darwinians who don’t do politeness while defending “junk” DNA (and RNA?) may wish to consider attending Remedial Miss Manners.

And a merry Christmas to all.

See also: “Junk” RNA helps regulate metabolism

Junk DNA defender just isn’t doing politeness any more.

Anyone remember ENCODE? Not much junk DNA? Still not much. (Paper is open access.)

Yes, Darwin’s followers did use junk DNA as an argument for their position.

Another response to Darwin’s followers’ attack on the “not-much-junk-DNA” ENCODE findings

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7 Replies to ““Junk” RNA plays key role in helping cells respond to stress

  1. 1
    Dionisio says:

    A study from Massachusetts General Hospital (MGH) investigators has found a surprising role for what had been considered a nonfunctional “junk” RNA molecule: controlling the cellular response to stress.

    surprising role?

    Why surprising ?

  2. 2
    tjguy says:

    If scientists really believed the Junk RNA theory, they wouldn’t study junk RNA to see if it has a function.

    I wonder if there has ever been an instance where junk RNA or Junk DNA, after being thoroughly studied, gave no evidence of function. Has there ever even been one instance of this?

    It seems to me the ID side is definitely winning this battle and the amount of “assumed Junk DNA/RNA” is shrinking almost daily.

  3. 3
    Dionisio says:

    tjguy,

    If scientists really believed the Junk RNA theory, they wouldn’t study junk RNA to see if it has a function.

    That’s an interesting observation.
    However, had they been more open-minded and thought out of wrongly preconceived boxes, perhaps they could have figure out long ago that there’s much more to biology beyond the incomplete ‘central dogma’ and the reductionist ‘selfish gene’ ideas.

    Why did it take them so long to look everywhere for the answers to the hard questions of biology? A 7-year-old child would have asked the important ‘how’/’why’ questions that may lead to deeper research and breakthrough discoveries. Where’s the humble unbiased thinking required for effective research?

    Why are there so many ‘unexpectedly’ and ‘surprisingly’ expressions in the biology research papers? Did they expect something else or nothing at all?

    Maybe translational “precise & personalized” medicine could have benefited from more discoveries long ago. Perhaps that biased attitude to research has hindered the progress of medicine and biotechnology.

  4. 4

    In my working days we built a complex distributed system consisting of 4 subsystems distributed over a large geographical space, interconnected with data links and including a subsystem containing a multitude of fast moving and maneuvering jet fighter aircraft.

    In constructing these systems, we used a process called ‘Engineering Release (ER)’ where the various components of each subsystem, as well as the subsystems themselves, were released to manufacturing via a series of ‘Shop Travelers.’ These travelers contained detailed instructions on how the components were to be manufactured and assembled as well as a detailed parts list.

    When the manufacturing process was complete, the various components and subsystems were integrated and tested in a lab setting, and then deployed and tested on site for use by fighter squadrons.

    Preceding all this of course was the necessary design work – a goal oriented, purposeful and intellectual expression of the vision of those who saw a need for such a system.

    It would seem that the human cell operates on much the same scheme. A cell containing complete and detailed information describing an end product and the shop travelers that guide that cell to its final use as a heart muscle, bone brain and more.

    It’s called Intelligent Design (ID), and is the way all complex systems are constructed, whether they be human designed or the natural life we see all around us and within us. To think otherwise is folly.

  5. 5

    Psalm 139:

    For you created my inmost being;
        you knit me together in my mother’s womb.
    I praise you because I am fearfully and wonderfully made;
        your works are wonderful,
        I know that full well.
    My frame was not hidden from you
        when I was made in the secret place,
        when I was woven together in the depths of the earth.
    Your eyes saw my unformed body;
        all the days ordained for me were written in your book before one of them came to be.

  6. 6
    Dionisio says:

    ayearningforpublius,
    Excellent comments. Thank you.
    Rev. 22:21

  7. 7
    Dionisio says:

    ayearningforpublius @4:

    “Preceding all this of course was the necessary design work – a goal oriented, purposeful and intellectual expression of the vision of those who saw a need for such a system.”

    Exactly.

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