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Mechanics as well as genetics is needed for viable embryo development


From Suzan Mazur at Oscillations,

With the ramping up of investigations in various parts of the world into the mechanics of biology, I’ve decided to post my conversation with Institut Curie biophysicist Emmanuel Farge on the role of mechanics in reprogramming the embryo [2010], relating to his work first published in the scientific literature in 2003, which was well received by the science establishment.

Emmanuel Farge

Emmanuel Farge:Exactly. Because you need the gene expression to have the germ-band extension. Then after you need the germ-band extension to have the expression of Twist at the anterior pole, which is mechanically induced. What I’m saying is that you always are in a situation where you cannot say that mechanics is more important than genetics and the reverse is true also. You have a strong coupling between the two.

Mechanics alone and physics alone is not enough. Genetics alone is not enough. Coupling both through mechanical induction allows us to understand this expression of Twist at the anterior pole of the embryo.

What we found in 2008, in fact, is that this mechanical induction of Twist in stomodeum is necessary for the correct tissue organization and formation of the anterior gut. If you don’t have this mechanical induction of Twist in the anterior pole cells, then the larva develops a gut but it does not express the good genes to make cells in order to digest. It’s not functional. More.

See also: The “beautiful mechanism” by which an egg becomes an embryo


Cells communicate to navigate a crowded embryo

“I would call the gene the complete process that leads to the expression of a protein.“ How does that relate to Richard Dawkins’ definition of gene? OLV
I stated this here at UD years ago: the question of what came first, the chicken or the egg? is definitely answered thusly: the EGG. Think of hardware and software. Though needing to be compatible, software is uselss without hardware. Genetic information, because of the 'genetic code', operates like software. It is the 'egg' that is primary. And it is with a different type 'egg' that different 'species' come into existence. Recently, I posted about how using mitochondrial "bar-codes"(COI), scientists were able to detect a high 'intra' and 'inter'-species correlation. Of course, mitochondria are somatically inherited--the 'egg.' Time will bring into focus the fact that "common descent" is really "uncommon descent." Then the fun will begin. PaV

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