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The War is Over: We Won!

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Here is the abstract from a Nature Review: Genetics paper:

The recent increase in genomic data is revealing an unexpected perspective of gene loss as a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This novel perspective of gene loss is raising new fundamental questions. How relevant has gene loss been in the divergence of phyla? How do genes change from being essential to dispensable and finally to being lost? Is gene loss mostly neutral, or can it be an effective way of adaptation? These questions are addressed, and insights are discussed from genomic studies of gene loss in populations and their relevance in evolutionary biology and biomedicine.

Many years ago, I predicted that modern genome sequencing would eventually prove one side of the argument to be right. This review article indicates that ID is the correct side of the argument. What they describe is essentially what ID scientist, Michael Behe, has termed the “First Principle of Adaptation.” (Which says that the organism will basicaly ‘break something’ or remove something in order to adapt) This paper ought to be the death-knell of Darwinism, and, of course, “neo-Darwinism,” but, even the authors who report this new “perspective” have not changed their Darwinian perspective. Somehow, they will find a way to tell us that the Darwinian ‘narrative’ always had room in it for this kind of discovery. As Max Planck said, and I paraphrase, “a theory does not prove itself right; it’s just that the scientists who opposed it eventually die.”

Here is basically the first page of the article (which is all I had access to):

Great attention has in the past been paid to the mechanisms of evolution by gene duplication (that is, neofunctionalization and subfunctionalization). By contrast, gene loss has often been associated with the loss of redundant gene duplicates without apparent functional consequences, and therefore this process has mostly been neglected as an evolutionary force. However, genomic data, which is accumulating as a result of recent technological and methodological advances, such as next-generation sequencing, is revealing a new perspective of gene loss as a pervasive source of genetic change that has great potential to cause adaptive phenotypic diversity.

Two main molecular mechanisms can lead to the loss of a gene from a given genome. First, the loss of a gene can be the consequence of an abrupt mutational event, such as an unequal crossing over during meiosis or the mobilization of a transposable or viral element that leads to the sudden physical removal of the gene from an organisms’ genome. Second, the loss of a gene can be the consequence of a slow process of accumulation of mutations during the pseudogenitzation that follows an initial loss-of-function mutation. This initial mutation can be caused by nonsense mutations that generate truncated proteins, insertions or deletions that cause a frameshift, missense mutations that affect crucial amino acid positions, changes involving splice sites that lead to aberrant transcripts or mutations in regulatory regions that abolish gene expression. In this Review, the term ‘gene loss’ is used in a broad sense, not only referring to the absence of a gene that is identified when different species are compared, but also to any allelic variant carrying a loss-of-function (that is, non-functionalization) mutation that is found within a population.

Here, we address some of the fundamental questions in evolutionary biology that have emerged from this novel perspective of evolution by gene loss. Examples from all life kingdoms are covered, from bacteria to fungi and from plants to animals, including key examples of gene loss in humans. We review how gene loss has affected the evolution of different phyla and address key questions, including how genes can become dispensable, how many of our current genes are actually dispensable, how patterns are biased, and whether the effects of gene loss are mostly neutral or whether gene loss can actually be an effective way of adaptation.

So, let’s translate what they’re saying here: “speciation” (their term is “phenotypic adaptation”) is the result of a LOSS of INFORMATION! This points, of course, to the “front-loading” of the LCA of the various branches of the so-called “Tree of Life.” Absolute bad news for Darwinism. We no longer say: “Another day; another bad day for Darwinism.” We now say: “Another day since the time Darwinism was disproved.”

This is what one of the authors has to say in an interview:

“The genome sequencing of very different organisms has shown that gene loss has been a usual phenomenon during evolution in all life cycles. In some cases, it has been proven that this loss might mean an adaptive response towards stressful situations when facing sudden environmental changes” says Professor Cristian Cañestro.

“In other cases, there are genetic losses –says Cañestro- which even though they are neutral per se, have contributed to the genetic and reproductive isolation among lineages, and thus, to speciation, or have rather participated in the sexual differentiation in contributing to the creation of a new Y chromosome. The fact that genetic loss patterns are not stochastic but rather biased in the lost genes[pav: IOW, this is where you’re going to find the genomic differences between species you compare] (depending on the kind of function of the gen or its situation in the genome in different organism groups) stresses the importance of the genetic loss in the evolution of the species.

There you have it: “evolution” through “gene loss.” I.e., “evolution” through “loss of information.” Evolution does not PRODUCE “information”; it DESTROYS “information”. You can read about in the book: “Genetic Entropy.”

In sum: the war is over, and we won! Congratulations everyone!

Comments
PaV, Thanks for drawing attention to this remarkable scientific finding. Without getting into much detail, the message is clear. The evolutionist claim regarding the natural development from simpler forms to more complex is under threat. Fortunately, the scientific process is free from emotions that overload some of the responses from our Darwinist friends :) Now the question is, where did the initial complexity come from? Game over.EugeneS
June 20, 2016
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From the website of the 'Universitat de Barcelona':
Thinking of gene loss as an evolution force is a counterintuitive idea, for it is easier to think that only when we gain something –genes in this case- can we evolve. However the new work by these authors, who are members of the Research Group on Evolution and Development (EVO-DEVO) of the UB, paints the vision of gene loss as a great potential process of genetic change and evolutionary adaption. ... “The genome sequencing of very different organisms has shown that gene loss has been a usual phenomenon during evolution in all life cycles. In some cases, it has been proven that this loss might mean an adaptive response towards stressful situations when facing sudden environmental changes” says Professor Cristian Cañestro. “In other cases, there are genetic losses –says Cañestro- which even though they are neutral per se, have contributed to the genetic and reproductive isolation among lineages, and thus, to speciation, or have rather participated in the sexual differentiation in contributing to the creation of a new Y chromosome. The fact that genetic loss patterns are not stochastic but rather biased in the lost genes (depending on the kind of function of the gen or its situation in the genome in different organism groups) stresses the importance of the genetic loss in the evolution of the species. ... Gene loss can become a positive condition. This has been proved with laboratory experiments (in yeast or bacteria) and population studies on humans. Some of the best studied cases on humans are coding gene losses with cell receptors (CCR5 and DUFFY), which make individuals more resistant to HIV infection and to plasmodium caused by malaria. In nature, there are gene losses from which some organisms benefited: losses which made colour changes in flowers which attract new pollinators, losses which made warmness-resistant insects to be able to colonize new habitats, etc. Some studies also suggest that gene loss has been decisive in the origins of the human species. Chimpanzees and humans share more than the 98% of their genome –something which has always been of great interest- and in this context it is tempting to speculate that perhaps it would be necessary to look for the differences not in the shared genes but in the lost ones- the ones which have been lost in a different way through the human and primate evolution. “For example, it is believed that gene loss reduced the jaw muscular structure, which allowed the human brain to grow its size, or that gene losses were important in the improvement of our defense system against illnesses”, says Cristian Cañestro. ...
Origenes
June 20, 2016
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I predict that creationists will have a field day with this new discovery as it seems to validate one of their main points they have been making for years. Evolution works, but the progression is not in the right direction needed to see a single cell turn itself into a human being. I haven't read the paper either so this is simply based on the OP. Losing genes and breaking genes is simple. No one argues that evolution can do this. We are all in total agreement on that point! The evidence for it is incontrovertible. However, the evidence for evolution in the opposite direction is much more theory driven and unclear.tjguy
June 20, 2016
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Alecia: Lets make this easy for you to understand. To go from a fresh water drinking land animal, to a salt water swimming 15 000kg whale, would require an immense increase of novel genetic information. This paper indicates evolution by gene loss, which is counter intuitive the usual Darwinian paradigm. Time to dust of your white flag.Rennie
June 20, 2016
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The war is over and I'd rather say it is everybody's loss. If gene loss is allowed to go on for much longer, kids will be born without genes.Cabal
June 20, 2016
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Alicia: Here's what one of the authors has said in an interview:
“La visión hasta ahora es que al evolucionar ganábamos en complejidad, ganando genes. Así se pensó cuando se secuenciaron los primeros genomas, de mosca, de gusano y del ser humano. Pero hemos visto que no es así. La mayoría de nuestros genes está también en las medusas. Nuestro ancestro común los tenía. No es que nosotros hayamos ganado genes, es que los han perdido ellos. La complejidad génica es ancestral”, sentencia Cañestro.
Here's my translation: “The view up until now is that to evolve means a gain in complexity, a gain in genes. This is what was thought when they sequenced the first genomes, of the fly, of worms, and of human beings. However we have seen that this isn’t how things are. The majority of our genes can be found in sea anemones. Our common ancestor had them. It’s not that we have gained genes, rather, it’s that they have lost them. Genetic complexity is ancestral,” said Canestro. The war is over: we won!PaV
June 19, 2016
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Alicia: Please. Of course gene loss is nothing new. As to it's saying "evolution is driven by a loss of information," they would deny this; however, that is the import of the paper. Here's what's new: extensive sequencing of genomes! I said 7 or 8 years ago, at a time when sequencing was becoming quicker and less expensive, that the comparison of genomes would either confirm the Darwinian view, or, that of ID. The evidence is in: information actually drives speciation, a complete inverse of what neo-Darwinism expects. It's the nail in the coffin. Holler all you want, but, the war is over: and we won!PaV
June 19, 2016
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PaV. Please. Gene loss is nothing new. They are saying it's been over-looked and has an important role in evolution, just as gene duplication, mutations, transposable elements, chromosome rearrangements, etc. all do. No where does it say that "evolution is driven by a loss of information." It's funny you think you can claim the research paper says "this" and "that" when you have already admitted to not even having access to the actual paper.Alicia Cartelli
June 19, 2016
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rvb8: You've succeeded in making a "mountain out of molehill." There could be lots of reasons for those numbers; meanwhile, the astronomically, infinitely small probabilities associated with even an average size de novo protein is enough to invalidate Darwinism. You "strain gnats, and swallow camels."PaV
June 19, 2016
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The Adder's Tongue fern has 1200 chromomes, the Human 46, the kingfisher 132, Great Apes and Hares 48, the Horse 64 etc. The thing is, the complete arbitrary nature in which these numbers vary, with a sea slug having maybe 400, and mushromm several hundred, and then an eathworm and Tibetan Fox sharing 36, tells me clearly there is no design. This utter randomness in the gene count, from the supposedly highest 'human', to the lowest bacteria points to chaos, not design.rvb8
June 19, 2016
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Alicia: Your comment makes clear that it is you who do not fully understand the implications of this review article. It basically says that what Darwinists believe is "evolution"-- you know, the "origin of species"--is driven by a "loss" of information, not a steady, gradual build-up of information. IOW, there is no foundation for Darwinism. But, of course, if an "intelligent agent" is involved, this "information" is infused, and this discontinuous infusion of "information" can also include mechanisms which allow for "adaptation" through a gradual LOSS of the infused, phyla-level "information," as in NGE. This paper is fully consistent with ID; it is the death-knell of Darwinism. The war is over: we won! The only thing that remains is for a declaration of surrender to be 'signed.' You can be the first to sign!PaV
June 19, 2016
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Gene loss is just another mechanism of evolution. It is not THE mechanism of evolution. You guys love to blow up research that you don't even understand.Alicia Cartelli
June 19, 2016
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rvb8: As I mentioned in my response to Alicia, the paper I'm quoting presents results that are: (1) the complete opposite of what Darwinism should look like; (2) confirmation of what a principle made by an ID theorist; and (3) confirms what a supporter of ID has written in a book. There you have it: complete rejection of Darwinian expectations, and, simultaneously, confirmation of what ID thinking people have stated is going on. It's not too late to switch sides.PaV
June 19, 2016
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Alicia C: Dear Alicia, I'm not being sarcastic. The war is now over. Your side has lost. What this review article presents is the complete ANTITHESIS of what Darwinian evolution should look like. Let me put it another way: Darwinism couldn't have been MORE wrong. As to my "misrepresentations of actual science," please consult Dr JDD's post.PaV
June 19, 2016
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Evolution is not "about gene loss." Are you guys completely incapable of detecting PaV's sarcasm? He's merely playing down another mechanism of evolution and even trying to spindoctor it into "support of ID." Unfortunately for you guys, this review paper in no way helps ID, and neither does PaV's misrepresentations of actual science.Alicia Cartelli
June 19, 2016
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rvb8 - "Couldn’t the designer fabricate a stronger template to prevent this error accumulation" Fairly irrelevant. You could take any design and say, "couldn't this be done better?" Just because it could have (or you imagine it could have) has no real bearing on whether or not something was designed. By that criteria, we have definitive proof that there was no one on the design team for Windows. "Or rather, with gene loss, and the resultant new expression, why can’t this new expression be beneficial to the individual?" It totally can be, but it is totally beside the point. The point is, if evolution is about gene *loss*, then that indicates it *isn't* about the gain of genes. If the observed pattern is that we *lose* information, then this isn't a good theory of where it comes from. The core of Darwinism says that life started information-poor and increased in information-richness over time by accumulation. ID, on the other hand, says that we *started* with fully-developed information sources. If the process of evolution is merely the getting rid of existing information, then ID was the one that was right.johnnyb
June 19, 2016
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I'm sorry PaV, but why does a gene which fails to function because of physical forces acting upon the gene, and then the resulting phenotype being expressed differently, prove Intelligent Design? Couldn't the designer fabricate a stronger template to prevent this error accumulation? Or rather, with gene loss, and the resultant new expression, why can't this new expression be beneficial to the individual?rvb8
June 19, 2016
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"But this is exactly what [insert favourite of Darwin, evolution, new-Darwinism, neutral theory, etc, etc] predicted" .....Dr JDD
June 19, 2016
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